r/ureaplasmasupport

I am negative! 3 tests, husband 2 tests! Past the 4 week mark. Took a biome test and it’s insane but everything was basically perfect. Totally felt better all in all, then we had sex on Monday, next day urethral irritation (no burning while peeing) it was more just a constant dull or ache. The next day Wednesday I finally felt normal again, and then a squatted to pee wnd kind of had to push the pee out and it immediately again felt the same sensation. The constant dull ache pain, and it’s been there since. Today being Saturday. Gradually feeling better. Has anyone else experienced this? I defiantly know my body is healing from inflammation, just looking for reassurance I’m not crazy.

I have been battling ureplasma for over 6 months now, a couple months back I was recommended to a gyno for if (ofc) and have been tested multiple times since being there, as well as have taken over four different rounds of antibiotics. Yet, I am still have all the symptoms (neon yelllow/greenish chunky discharge, weird smell, burning, itching, symptoms of yeast infection/uti, etc etc. I’m getting extremely tired of living like this, and I’ve explained how frustrated I am to the doctors, all for them to keep shoving the same antibiotic back in my face when it’s CLEARLY not working. I’ve don’t some minor research and to my understanding ureplasma can become immune basically to certain antibiotics if you’ve taken them a bunch, which is what I’m worried is happening, but as I said after time I go back to the gyno they keep giving my doxycycline or azithromycin, which again neither of them have worked. I’m extremely upset and frustrated and unsure of what to do at this point. Any advice would be extremely appreciate thanks!

Hi everyone, hope you guys are having a good day. So after failing multiple treatments, I finally had to discuss my treatment plan online. I had been lurking here for months and didn't want to interact with you guys because, of course, I don't like to take medical advice from strangers, but I have finally given up.

I already failed conventional treatments like doxycycline, azithromycin, clarithromycin, moxifloxacin, minocycline, etc. Even potent experimental antibiotics like pristinamycin and sitafloxocin didn't work.

Both pristinamycin and sitafloxacin were used for 10 days with doxy pretreatment.

So this time I have 30 lefamulin tablets, 600 mg each. I also have some minocycline and doxycycline. I have around a week's supply of doxycycline, while minocycline will last for 3 weeks.

So what should be my treatment plan?

Should I do doxy with lefamulin for10 days or Mino followed by lefamulin or should I do the 15 days total since I'm afraid it might not work. Please advice me on this situation my gyne has already given up also how many people used lefamulin and succeed?

Hi guys 28M here from UK, I know this might be something that can be found in the sub/repetitive but it’s a tiny bit different. Sorry for the long post

I have had some symptoms and pain since November/December last year following unprotected oral sex, however burning when peeing hasn’t been a big one, it’s happened a handful of times not my main symptoms. I have had some irritation itching of the urethra though but my main symptom has been pain in the testicles, abdomen and lower back. They all come and go and change in intensity but mostly everyday I have been in some sort of pain. Also my semen consistency has been unusual since this all started and my pre ejaculate has been a lot thicker than before and I produce a lot more.

The thing is I have never had a positive test, I’ve tested 3 times for UU and twice for UP all urine PCR. It’s not as though I have tried treating and then testing negative, just haven’t had one at all. All samples I gave were holding urine at least 3/4 hours of not first urine of the day. I’ve tested 3-4 times for everything else aswell. The only antibiotic I’ve taken since the start was Oflaxacin in December but I started testing for mycoplasma/ureaplasma 5 weeks after finishing. And then of course tested more as more time went on

I’m really confused and losing my mind over if what I’m experiencing is mental or something else but what blows my mind is that my eyes have also been irritated for a couple of months now too and I have wbc 74 /uL in my urine. I’m in a really difficult position because I never knew this existed and thought I was clear for everything, the oral sex I received was during a break from my long term partner. I didn’t disclose anything as I didn’t want to hurt her but after we got active again, she started showing unusual symptoms too. I’m really scared and this has been the most mentally taxing 5/6 months of my entire life. I feel that I need to tell my partner to get tested and I’m so terrified of causing her such pain, things have been difficult between us as it is. In need of your thoughts please I’d really appreciate it, I’m slowly realising I’m really devastated over all of this.

Bonjour

J'ai été testé ureaplasma parvum au niveau vaginal en décembre . J'ai eu 5 jours d'azitromicine mais j'étais à nouveau positive avec test en culture avec un taux à 10000, et positive au test PCR.

J'ai eu ensuite 7 jours de moxifloxacine les symptômes se sont améliorés par contre je suis toujours positive au test pcr mais négative au test de culture. Mon médecin me dit que si je suis négative au test en culture c'est que je ne suis plus infectée et le test positif en pcr c'est simplement parce que U.P est présent chez pleins de femmes de manière normale .

Par curiosité j'ai réalisé un test vaginal ma flore est excellente, je n'ai aucun autre germe ou mycose par contre mes globules blancs ont augmenté et il y a écrit inflammation sur le compte rendu du laboratoire. Je me dis que c'est U.P qui cause les globules blancs .

J'ai aussi réalisé une biopsie de l'endomètre pour vérifier au niveau utérin et je suis négative.

Un médecin a accepté de me prescrire 14 jours de doxy puis 3 jours jour d'azitromicine. Je ne sais pas si je dois prendre ce traitement ? Je ne sais plus quoi penser.

Je précise que mon conjoint est traité à chaque fois et que je réalise les tests 6 semaines après les traitements.

Has anyone taken this bio film defense ALONGSIDE treatment for UP? Just wondering how/ when you’re supposed to take it? Thanks!

Hii everyone 👋🏻
Backstory - I’ve suffered from chronic yeast (glabrada) and bv for 6 years.
I was always given Diflucan and never tested positive for anything else stds etc .. healthy early 30s. Tried everything unconventional boric acid, herbs, supplements etc always reoccurred w sex

One day I got fed up with it reoccurring and asked for more in depth testing on what my yeast was that’s how I found out I had glabrada not Albicins or anything else - so basically my gyno was treating me for something that was resistant to that medication - I was pissed bc now I had messed up my whole system.

Fast-forward I ended up finding a specialist infectious disease, Doctor Who treats glabrada and different reoccurring issues - he ended up treating me and I stopped the million different supplements and all the stuff I was doing and just let my body heal. It ended up working and I got rid of the yeast.

Fast-forward to 5 months later -
TMI I started trying anal sex while I’m on my period - no switching just anal no condom - we are both clean etc before anyone starts on the washing. We don’t have sex after for probably five days since I’m on my period for that long once I’m done w my period we will have sex vaginally. And then within the next week, I automatically started getting UTIs.

I’ve had three E. coli UTIs every month since January blood pain, urgency, and all - I have done microgenx testing and it came back positive for ecoli and ureaplasma but nothing else. I’m struggling and terrified now to have sex and I don’t know what to do. I went to my urologist and she gave me macrobid to treat the utis and now have me doxy for the ureaplasma ureticylum. She also told me to potentially treat my partner but he has 0 symptoms.
I contacted my infectious disease doctor and told him about this and he went on and on about how I shouldn’t have to treat the urea and I’m causing more harm because it causes yeast overgrowth and could cause chronic yeast to come back.

I’m feeling lost because I don’t know what to do trust my urologist or trust my infectious disease doctor

I’d love some opinions or success stories pls help 😵‍💫😑 - also could it be from anal!? It’s the only thing that I have changed before starting to get these UTIs

I just found out I have bv and ureaplasma and i’ve been taking metronidazole and azithromycin for a couple of days. I want to get drunk tonight since it’s my birthday but apparently you’re not supposed to on those medications. Is it really a big deal?

I went to my PCP to discuss a reoccurring issue that in my opinion does not fit the symptoms of ureaplasma. I started to have a "leakage" issue where end of the day my underwear was sometimes damp / not completely dry. My discharge was normal, my urination was normal, and the only odor was ammonia which checked out with the leakage problem. My doctor tested me for ureaplasma NAA and it came back positive. I started a 7 day doxy treatment and my partner is getting tested this week.

My partner and I have never had penetrative sex. He has given me oral once briefly but stopped because of the ammonia smell which is what promoted me to go to my PCP. The oral happened a month ago since he did not tell me there was a smell until recently. I guess I should have known but I guess I didnt think there was an issue idk. I dont feel like I had a UTI. Ive gotten BV once and a UTIs but it's been years and I remember how those things felt. This does not feel similar.

I dont feel like getting treatment for this is actually going to address my problem. Im annoyed that ive been STD tested far more times than partners ive had and this has never come up before. Im embarrassed my partner is the one who had to notify me there was an issue. Im pissed off there isn't much information on this. I feel bad I might have given my partner this.

Im just so lost right now.

Hi everyone,

I just found this sub, wish i did months ago. Heres a little backstory

I had first felt symptoms october 2025 and i got put on so many random antibiotics to no avail until i starred becoming suicidal. Finally got put on doxy for some other issue in december, but unfortunately was unknowingly reinfected by my partner. Finally in March 2026, they did a UU and mycoplasma test and i had M. Hominus. My partner and i got put on doxy (now my 6th round of antibiotics in 6 months). And i was cured.

Fast forward to now, i have had a dehydrated week and had very mild burning sensation symptoms. And a tiny bit of urgency to pee. Well today i definitely got dehydrated and i also started my period. And now i have medium pain symptoms, urgency to pee and burning in urethra. I have chugged water and am using a warm bottle for comfort.

I usually take a cranberry supplement and lactobacillus probiotic, but forgot most of the week, because i was visiting family.

My question is, are lingering symptoms common? Its been almost 2 months now since my last antibiotic round. I heard these bacteria cause tissue damage, so maybe my period, dehydration and forgetting my supplements brought back the pain? I will say i also just got diagnosed with fibromyalgia and have always been extra sensitive.

I will say i have been 100% better since my last antibiotic round, but this week of mild pain and then this past hour, has got me on edge. Hence the post.

Should i go get tested again? Should i request to get on doxy again? I dont want another round of antibiotics but im scared this will return. It got so bad im literally on temporary disability cuz of the mental and physical misery i was in. So a tiny flare up of symptoms is so triggering, and im pretty terrified of it returning. Any advice would be so helpful

Thank you for anyone who offers advice. I’m about to start a new treatment plan. The infectious disease doctor is telling me to take Minocycline and levofloxacin at the same time for two weeks. I know this is an aggressive treatment and I’m okay with that! My question is, should I do a week of mino before starting the two week treatment? Or just do as instructed. I’m open to any advice. Thank you!

i tested positive for ureaplasma a couple days ago after unprotected sex 2 weeks ago with a new person. he was just a hookup, we had sex twice. i'm trying to understand ureaplasma and from what i've gathered it's not classified as an sti but is sexually transmitted, so do i need to tell him to go get tested since im assuming that's where i got this from? if yes, i am a little hesitant because i have a really strong feeling he's going to get upset and turn all of the blame onto me. or he's going to ignore me and not go get tested at all.

I was fully healed and didn’t sleep w the guy who i slept w when i unknowingly had urea. Anyway. I had him test and it was negative but i still made him do the same treatment as me. After about a month of finishing treatment he got tested for urea again w a pcr test and it was negative. I also was negative but i didn’t sleep w him for months. We had sex finally w a condom and i was fine.. then we tried sex unprotected again for tnr first time in forever and i felt okay too.. a week later we did it again and the day after that i have bladder pressure like how i did w my urea symptoms 🙃🙃

Hi all after a long battle with this I’m finally seeing the light at the end of the tunnel!
My last antibiotic was Christmas Eve test of cure first week of Feb with co infection testing all negative. Was still having some flairs so me and my doc decided to do an evvy test. Neg for everything except a low amount of bv. It was literally .1 percent lower than my obs lab level. Did boric acid for 12 days followed by flagyl. Two doses of yeast infection meds (forgive me I can never spell the med name correctly) and switched my probiotic from the metagenics one to happy v. Along with pelvic floor pt (I’m on week 6) my symptoms are very minimal and more irritation like now. My pelvic floor pt was an able to find what nerves were causing my burning itch and is working on fixing it!

There is hope out that you don’t have to live with this forever.
I am aware that some people are living with this chronically and I pray that one day you find relief!

So short story, positive for mycoplasma Hominis & urea. U. , I haven’t treated it at all because I’m pregnant & wanted to wait. Now I’m 35 weeks & have been taking NAC + D mannose + L. Crispatus for 2 weeks & on its own my urine tension has settled down. I can only take azy.. but given that my symptoms have settled down & im due soon , it seems to be the only option & I am hoping that the NAC has busted the film so that other antibiotics aren’t needed. I took .5mg today & will every 12 hours for the next 3 days. I won’t be able to get retested until after she is born or maybe just before if I make it to term( a month). How likely does it seem that it will work? I plan on staying extremely hydrated while taking medication to help support the flushing of bacteria & continue with an oregano oil shot at night. I’ll be having a girl & know how difficult this could be if it is transmitted vaginally.

Last year I (F28) had chlamydia in august and PID in September after a month. I got better with PID meds but pelvic pain came back after 1.5 months in December. I have been suffering from pelvic pain since. Its been 5 months now. I have pelvic, abdominal, vaginal pain. Feels like burning at times but no itching or visible sores.

Now for the last one month, I have been having eye pain, blurry vision, light sensitivity. I saw an optometrist and she prescribed an eye drop which isn’t helping. She says i have inflammation in both of my eyes.

My chlamydia, gonorrhea, syphilis, HIV, hepatitis came negative many times with urine and swabs both. I also did get tested for ureaplasma and mycoplasma using urine and swab both but I was in between antibiotics like vancomycin, clindamycin, amoxicillin, septra ds, metronidazole. The last time i took doxycycline was 6 months ago.

I have done EVVY, JUNO tests as well. Since i am in canada they dont test for M.Gen. But they seemed to do everything else. I also got tested at sexual health clinics but nothing shows up. I am really worried as i feel like something is severely wrong with me thats not showing up

P.s: i haven’t been sexually active since my chlamydia infection

Ive been suffering with this for about a month but ive had reoccurring Bv for 5 years. Im scared that because ive waited so long the medication wont work.
Im currently on day 4 of doxy x2 a day, and the only thing that is decreasing is the urgency to pee. My doctor also only wanted me to take it for 7 days but i was able to get 14 days and the moxi. i want to get rid of this for good. i tested negative for all the other std/sti’s.
My symptoms before the medication:
\-pain all over my back
\-pain in urethra
\-fishy, yellow discharge
\-alotttt of discharge
\- going to the br every 20 minutes

Can anyone write when did they start feeling better?

So I tested positive for Ureaplasma AGAIN. I feel so beyond guilty for exposing my new partner after thinking that it was gone. Back in April 2025 I finally found out after having recurrent vaginal infections for over a year that I was also positive for ureaplasma during that time both me and my ex took doxycycline, I did 2 weeks due to suspected PID, he did one week. This in itself made me so angry he was knowingly positive well before we got together but because the doctor told him it was normal he didn’t mention it. A month and a half after treatment it was negative by NAA and I was ecstatic. All symptoms disappeared and stayed done. Before starting a sexual relationship with my now boyfriend in January I got tested for all STDs and requested mycoplasma/ureaplasma testing but it was my fault for not demanding it be done by NAA/PCR so the culture came back negative, I thought I was okay. All of a sudden the middle of April comes and my body freaked out I got BV a UTI all of it and then came the persistent urinary symptoms. We started having unprotected sex in the middle of February. Based off sexual history it does not seem likely that this came from him so I’m trying to figure this out and it’s making me spiral, it’s causing turmoil in the relationship and thoughts about cheating which I could never do to anyone let alone to this man that I love to the end of earth. He’s getting tested now and I did susceptibility testing to see if anything comes of it.

If anyone can give me rational explanations to this, I want to cry and scream at the same time that I have to go through this allll over again, I want it to be gone. How do I handle the thought of cheating, when it was insinuated I completely shut down and could not speak, it broke my heart to think that was a thought that would cross his mind. How do I handle him having to take medication because of negligence on my end for not having the right test done. Everything about this makes me feel guilty and gross.

I was prescribed 7 days of Doxy and I am on day 5. My symptoms were pretty mild from the start, i was having a leakage / ammonia smell.

I feel very *aware* of how i feel now and it feels off. Not painful but like not natural. I’m worried the 7 days isn’t enough to clear the bacteria.