r/trintellix

Just want to get a feel if this actually works for anxiety

How extreme was you with 10 being the highest e.g constant physical anxiety, couldnt go anywhere etc

What mg helped or did not help and how long.. did it get worse before better

I'm wondering whether my tiredness ~1-2 hours after taking my 10 mg dose (AM) lines up with other people's experience? It should only reach maximum plasma levels 7-11h after ingestion, so I'm contemplating whether my tiredness can actually be linked to the meds? Pharmacokinetically it does not make a ton of sense to me?

its been about a week since i started 5mg of brintellix and my brain is so quiet holy shit. for context ive been struggling with very bad anxiety that would often leave me with the worst brain fog and just aches everywhere. debilitating and i couldn sleep at all. I never knew my anxiety could give me so much physical symptoms until I went on this medication and now they're almost completely gone. I would always wake up with tension headaches from clenching my jaw so much. bad bad aches everywhere.

Just wanted to share this positive experience because asking for help is definitely worth it! I hope that we are all kind to ourselves moving forward :)

Before Trintellix, I had already tried Lexapro, Sertraline, and eventually Paroxetine. Paxil honestly worked the best for me — my anxiety, overthinking, and negative thoughts became manageable, and I finally felt stable and in control of my life again.

The downside was the sexual side effects: ED, anorgasmia, and almost no libido. That’s why I switched to Trintellix. It definitely helped restore my sex life, but mentally and emotionally I feel like I’m struggling again. I’ve been more anxious, emotional, easily startled, and it feels like a lot of the negative thoughts are coming back.

I’m only 2 weeks into Trintellix 10 mg, but right now it feels like I’m back to square one. For anyone who’s experienced this — when did it start getting better for you?

I take mine in the afternoon. I haven't been on it long (5 days). Just wondering if theres a better time to take it.

Any details are welcome! I’m particularly looking for stories of people who felt worse before it got better (it first felt good for me, now it feels worse, my doctor told me it’s probably the right meds if I reacted well at first and to be patient but I’m looking for hope/successful stories as I’m having a painful experience right now!)

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Was getting no side effects really at 10mg and no real benefits

Now 2 days on 20mg nausea and fatigue are kicking my ass.. how long for this to settle also why the fatigue thought this meant to be pro cognitive

I’ve been taking Brintellix for two months, and a steady dose of 20 mg for over a month, and although I sometimes have brief moments during the day when I feel good, they only last a few seconds—and honestly, 90% of the day is pure torture for me! Every other antidepressant worked exactly the same way—there were only fleeting moments of well-being, but I could never permanently unblock my emotions enough to feel good and be at peace.

I started taking Brintellix two months ago, and I’ve been on a steady 20 mg dose for over a month now. Although I do have moments of “normality,” they’re very rare; I’m constantly having negative thoughts, I have distressing images in my mind, and I’m consumed by the darkness of my thoughts. Has anyone else had a similar experience and noticed a difference after more than two months?

Been on 20mg 4 days now I am being treat for severe anxiety and depression

The anxiety last couple of days is totally out of control my body is extremely anxious and my mind is racing 100mph and don't know how to calm it. Even the benzos not really taming it. None of my coping strategies are working

I think its having a small effect on depression a little

How long for this to pass its unbearable, as a note iv been on lower doses 3 weeks now.

I started taking 10 mg of Trintellix for a month to treat anxiety and panic attacks. I then increased the dose to 15 mg for another month. Today I went to see my doctor to switch medications because I feel the effects are either insufficient or are actually making my anxiety worse. He suggested switching from Trintellix to 5 mg of escitalopram (Lexapro).

I’m worried I’ve wasted time or that I’m stopping just before things start to get better. Any thoughts on this? Should I continue taking Trintellix for a few more weeks? How many more weeks?

Thank you very much for your time

To start I have horrific health anxiety and ocd. Looping thoughts, scared of everything, scared of meds that they will “poison me” I took lexapro about a month ago and held off on it for a month before taking it and within 2 doses I was having dpdr panic attacks and I felt like I was on drugs but it was a bad high. I now have 5 mg Trintillix and I am horrified. Dpdr is so scary and I am learning how to not let it control me and my biggest thing right now is I fear after I take the pill I will spiral thinking I’m poisoned. Living this way is crippling and being scared of meds that could help me is even worse. I just want to know if there was anyone who has taken Trintillix that was just like me before and how it was. I hope for only positive responses as I am already scared. I also struggle to take pills it’s one of my fears (choking) my pharm said not to crush but my psych said it was okay but I want to ask you guys if you know if crushing is okay?
Thank you in advanced I know that was a lot.

I was on 40mg vortioxetine for ocd almost one year. Recently i deceided to reduce the dosage . Its day 23 im on 30mg . Withdrawal symptoms got worse from day 15 . I feel panicy most of the day , overthinking , more intrusive thought ... i dont know what to do . When do these symptomes go away ?

I want to preface this by saying I’m not buying into the RFK scare tactics. I’ve been in this mindset from the beginning. I wanted to try medicine as a short-term tool to lower my baseline anxiety enough to be able to push through discomfort and accomplish exposures (I have OCD).

I’ve been taking 5mg for 10 weeks and my plan is to give it a full 6 months and if I notice success with completing exposure therapy I want to taper off of this.

Being on it for 6 months, my psychiatrist told me it’ll be very easy to just stop cold-turkey and she said that no matter the duration, only 3% of people experience any withdrawal symptoms at all due to the long half life and out of those 3%, almost all of them were on 20mg.

Any personal stories from people here who can tell me what to expect when I decide to get off of it? Is it going to be an easy stop from 5mg or would you recommend a drawn-out taper?

I’m 23M and have been on 10mg for a month. Feel nothing positive and slightly strange in general. I’d this just a phase before it gets better? God I hope so

I really don't know how to feel, but I know that after going from 5mg to now 10mg, I still need to give it a bit of time to adjust. I can definitely feel the 10mg as I am nauseous 24/7. It's not a "oh shit" level type of nausea, but I would say it is moderate to the point it does bother me and I generally feel unwell. Again, still bareable but on the edge of being catastrophic lol.

As far as the other negative side effects, I became a big ball of pure rage. I sometimes have weird and aggressive adrenaline spikes where I just want to punch shit. It did happen on 5mg every idk, 5 days or so but now I am guaranteed to have at least one or two episodes a day. Sometimes they have a trigger, sometimes not. I'm just overall much more impulsive, even though the impulsivity was already there before Trintellix. I have a whole emergency protocol when that happens as my fuse is so short, I never feel it coming before it is too late. So I just tell myself to shut the fuck up as to not say anything that I will regret (especially at work, high pressure, fast paced job), when I can I have a tall glass of water or just lock myself in the walk-in freezer as a timeout. And if something triggered me, I just tell my coworkers that I need some space and will explain later. It works for me like I said when I am already in crisis mode. Also, when I get home, I just chill for 1 or 2 hours with very little light or sound, I do a chill activity that doesn't require thinking. I need this calm "me time" to decompress.

As far as the positive, yes I would say being in a good mood seems more accessible overall. But in contrast, all my repressed emotions, good or bad are all back and they have a megaphone and they got shit to say. I still don't feel any motivation, little pleasure, and overall I still feel empty and bored but now it has a different flavor. I feel slightly overstimulated and like my nervous system is on edge.

It's a game of wait and see.

This is the first day I start taking it

Im in a really bad place and need to get to 20mg ASAP

I am thinking tommorow to 20mg I have severe anxiety and depression

Im 15 days nows and last 5 days on 10mg

Iv been crying a lot dont know if its from depression or side effects.

Other then that not alot of nausea, but I do have racing mind at night even though tired doesnt switch off.. will 20mg make this worse

Hi, I recently went again to new psychiatrist after long break from having very bad experience with my previous one.

I stopped taking my previous meds, because I was stupid, around 1.5 years ago. It was paroxetine and lamotrix and I was taking those for 4 years maybe? No side effects beside them not really working for me, so my new psychiatrist prescribed me brintellix 10mg and lamotrix again, 25mg

I was told brintellix is similar to paroxetine and since it was fine with me previously, it should be fine now.

First day I managed to not vomit but I was hella miserable whole night and couldn't sleep at all.

I'm taking it in the evening

Second day is today and I took it about hour after eating light salad. I was lying miserably for 2 hours trying to keep that in but I finally vomitted once, then twice then trice and there's no more left beside vomitting water and stomach acid. Did the pill even get absorbed??

I heard that nausea is expected, but should it go that far? I'll try call the doctor but I have visit next month and there's no fucking way I'm taking it the third day. I hate vomitting so much and it comes with huge headache.

I don't know what to do really and I write it crying over the toilet vomitting again:(