r/recurrentmiscarriage

My toddler will be 2 in 3 weeks. We started trying for a second baby only days after his first birthday. Three losses and one year later I feel so guilty for how sad I have been for literally half of his life. I have not been fully present or fully myself because of the grief of my pregnancy losses and the desperation for a healthy pregnancy. I want so bad to give him a sibling. He deserves so much more than this. He deserves so much more than me

Me (38) and my wife (37) have been trying for our first for around 6 months now. We've have had two positive tests, first ended at around 8 weeks and second at around 6.

My wife went for tests in a fertility clinic after the first loss, but the second positive came in the middle of these tests and they had to start again from scratch after the second loss. I support her and have gone for semen analysis too, mobility is on the lower side but we won't know the full picture until all her bloods are done at the end of the next ovulation cycle.

My fear is that things are being too delayed with these tests and we should just keep trying and hope something will stick eventually, I'm scared we're running out of time and it's making me very anxious.

Has anyone been through this or have any advice?

Hi everyone. I’ve had 3 chemicals in a row (each chance we’ve tried) the first two last year without any medication and then I went an entire year with messed up cycles and never ovulating on my own, triggering periods. No clotting disorders, PCOS. Last cycle I did letrozole 5mg, trigger shot, progesterone support and had another chemical pregnancy. CD3 and starting letrozole 5mg again CD5. My doctor has not mentioned baby aspirin but I’m thinking maybe it could help? Could it also hurt?

We think part of the issue was my husband has been taking baths everyday for yearrrrsss so he stopped those about a month and a half ago cold turkey as we think we had some DNA sperm fragmentation going on + he started COQ10. So I’m hopeful that will help as well and may very possibly be the cause of all 3 losses. Just looking for some thoughts, thank you.

Hi everyone,

I’m looking specifically for experiences with prednisone in natural or IUI (non-IVF) cycles after ovulation or around/during conception and early pregnancy.

Would really appreciate if you could share:

- When did you start prednisone (before ovulation, after ovulation, or after a positive pregnancy test)?

- If you started prednisone after ovulation but before a positive test, did you notice any difference in implantation or pregnancy outcomes?

- Did your doctor explain the reasoning or significance behind the timing of starting prednisone?

- What dosage were you on and how was it tapered off? Did you notice any side effects?i

Also, if you’re comfortable sharing, did it lead to a successful pregnancy for you?

Thanks so much in advance—really appreciate any insights or experiences 🙏

In the middle of miscarrying my second consecutive loss. First loss was MMC (passed at 12w, baby stopped growing 7w) in September. I’m 7w and miscarrying again.

I’m 28. I eat well, exercise, take a prenatal, healthy weight. I do have chronic hives, so I know inflammation and autoimmunity is a concern for me. Husband is healthy - could cut back on his nicotine use, but otherwise very healthy. After the first loss, me and my husband took Coq10 for egg and sperm quality. Took 5 cycles to get pregnant the second time with religious BBT and OPK tracking.

This is so hard. I need encouraging words - I am worried this is happening at 28 yrs old. I also want recommendations for next steps. Is it too early to see RE?

Thanks so much everyone ❤️

I told myself if it ever worked I would come back and write a post because I read so many stories looking for information and hope during my losses.

I had three MMC’s within a year, one of which was an IVF euploid embryo after seeing a heartbeat. They were all before 8 weeks. After the euploid I really struggled - if that didn’t work what would?

Last week we welcomed our baby and I wanted to share what I think helped me because I always looked for similar stories.

- all of my testing was normal. I had the full blood work up, hysteroscopy, husband had fragmentation, karyotyping etc. we also didn’t have trouble conceiving, just getting it to stick past 6ish weeks.

- I chose to skip the receptiva test and went straight to lap surgery. They found some endo, I’m not super convinced it was the problem but I’m glad I did it. I did an egg retrieval after my lap surgery and had better results, so not only do I think it didn’t cause damage but I think it helped my egg quality.

- Lovenox is what I think made the biggest difference. I was on baby aspirin for my third loss, but pushed for Lovenox the next time and I think it really helped me. I took it the whole time and switched to heparin at 36 weeks. There was nothing in my bloodwork to indicate I needed it but I really believe it allowed my pregnancy to continue.

- I was also on an immune protocol that I don’t think hurt with prednisone, Claritin & Pepcid.

I am happy to answer any questions here or via DM. Dealing with multiple losses was honestly the hardest thing I’ve ever been through and something that helped me was learning questions to ask my doctors and seeing what helped others.

I’m at home all the time (I don’t work due to mental health problems)

My third mc was really really hard for me and I want help on how I can just get through the next pregnancy (if I’m able to get pregnant that Is)

I thought of a few ideas so far:

- one counselling session per week (it’s gonna be private and I’m scraping by to afford that session)

- painting fairy houses ( I got four kits one per week to just paint)

-praying

- dancing

-watching movies (I’m gonna curate a whole list of my favourite movies)

- in my two previous pregnancies I got sch and was reccomended bed red but my miscarriage specialist dr Siobhan quenby told me to do yoga and swimming and remain active to manage my mental health. In my third pregnancy the day I started bleeding was the day I lost the pregnancy (so I am abit worried about keeping active)

- I’m gonna buy a pregnancy after loss journal too

Anymore suggestions would be amazing 💕 please don’t include anything food related as I’m recovering from Binge eating disorder and I need to manage my weight

I’m under Tommys clinic in Birmingham I’m not sure what sort of services they offer once pregnant again after loss but I’ve found the nhs therapist and people to be less empathetic and hard to talk to

I (25F) and my husband (28M) have been through two miscarriages at 6/7 weeks. Each pregnancy took about 6 cycles of trying.

I’ve had an hsg and all the normal blood testing and everything has come back normal. I don’t want to lose hope, but I’m so scared of getting pregnant again without changing anything and losing another much-wanted baby.

Is there anything else I should be testing? My doctor told me there’s nothing else they can do, but I feel like there must be more that can be looked at?

Thank you all in advance for any advice or success stories!

Has anyone had success sending in POC super early? Im 12 days late on my period and just passed the tissue. I'm pretty confident it's the sac and all. I was wondering if anyone had sent in their baby this early and gotten results?

Hi, I’m new to this thread and I wanted to share my story in hopes that someone can relate and offer advice.

My first pregnancy that started in August 2025, ended at 17 weeks when we made the painful decision to terminate due to severe brain abnormalities. During this pregnancy my NIPT was positive for trisomy 13 (later confirmed negative after amnio - it’s possible it was confined to placenta but never had placental testing). We later found out the baby had a gene mutation called INF2.

My second pregnancy was a chemical in December 2025.

My third pregnancy that started January 2026 was an-embryonic / blighted ovum that ended at 8.5 weeks.

We are now seeing a fertility specialist to determine next steps. So far all of our testing has come back normal (infectious work up negative and neither of us are carriers for anything). The only concern is my AMH is low at 1.08 (I’m 29). We’ve discussed options such as clomid or IVF for suspected poor egg quality.

Does anyone have a similar story/ have words of advice going forward?

Title says it all. Husband is 40, I'm turning 36 in a few months, we are lucky to have one beautiful little girl who just turned 5. Last May, we lost our son at 17w and then in October we had another loss at 9w. Between trying to conceive baby #2 and the 2nd loss, it was a full year of essentially living "on hold"; trying to get pregnant, getting pregnant, going through loss, and repeat. We both agreed to take a minimum 6 month break, and we had planned to start TTC again in May. But as the month approaches, I'm not sure I want to try again / anymore, frankly. It's not just about the fear of another loss and/or the fact that any future pregnancy will be considered high-risk and I'll have to take blood thinners (I was found to have lupus anticoagulant, which may have caused the previous losses), although those are considerations. But I'm also tired from living in the what if, and frankly, I don't know if I have it me to plunge back into the newborn trenches / toddler years etc, even if we were successful, especially as I just feel like we've settled as a family after the grief of the past year. Obviously I may regret this decision (I always envisioned having more than one child) but would it be wrong to tell my husband that I've changed my mind about trying again?

I am 32 and my husband is 30. Pretty healthy, been trying for a year and a half. And in the past 6 months goth pregnant twice first one was a blighted ovum ended in D&C at 8 weeks and second ended in natural MC at 6 weeks.

This whole experience was changed who I am in so many ways but one I didn’t think it could happen … I am a pretty social person and since this has happen I have 0 desire to be social. Like I literally couldn’t care less abt other people’s problems or things going on… like truly I am like yep no I don’t give a fuck! I thought it’s just because I might be sad but I think I finally figured out why…

Last week I saw a Neighboor and she knew abt my Mc we are not super close so when she asked me how I was I just said “yeah we are good still trying to have kids soon but not luck yet” and she responded by saying “well you know there is research showing that there is a correlation that when you relax” … you get the point! … I was so fucking pissed but of course I was nice to her. When we left and the few days after I just kept thinking - well is my fault I should not bring it up. And that’s when it hit me … I don’t wanna be social because I have nothing to talk with people and I just don’t care too much abt others rn. When they ask me what’s up with you I have two options fully lie and try to find something mundane to talk about … or be honest and tell them where I am at … 99% of people if I am honest say stupid shit back or they change the topic. 1% might be gracious and just listen and be nice but even those they have not been on my shoes and I don’t know anyone that has had multiple MC.

Anyways just sharing in case you feel this way too! You are not alone!

Oh and I also figured out yesterday that I am freaking terrified to try again we have taken a pause since my like Mc because we are doing testing and damn I am so scared to try again.

Last thing if you have found how to hold to hope can you please share with me … I’m struggling

Hi everyone,

I’m trying to understand how progesterone support is used in early pregnancy, especially for those who’ve had prior losses or needed luteal phase support.

If you’ve taken progesterone:

- What dosage were you on?

- Which route did you use (oral, vaginal, injections)?

- When did you start it (e.g., after ovulation, after positive test, etc.)?

- Did your doctor monitor progesterone levels or just prescribe it empirically?

- Do you feel it made a difference in your outcome?

If you’re comfortable sharing, a bit of your background (like previous losses, diagnosed conditions, etc.) would really help add context.

Thanks so much 🙏

33 YO Currently waiting for my HCG to drop after my 4th early loss in 2.5 years. (3 of which within 7 months) This one was an ectopic caught early and treated with the injection.

Seeming to check off every loss in the book… MMC, Blighted Ovum, Chemical, and most recently Ectopic..

Is it bad for me to just wanna give up? What’s my next steps here? My RE keeps saying IVF with testing it must be chromosomal. But come on man, something has gotta give! The last 3 early losses have not even concluded on their own. They’ve all needed medical intervention which is even more frustrating. I’ve got Factor V Leiden & .6 AMH. This last pregnancy we supplemented with lovenox & progesterone but ended ectopic 🙄

I just need some advice, well wishes.. hell idk. But I’m over it.

I hope this question isn’t stupid, I’m just new to this and wanted to be prepared. My fertility doctor said they will run some tests on me. I can’t meet with her to discuss until the end of the month because that was the only available appointment. What tests would they typically do?

I’m 40 and I lost one pregnancy naturally at 6.5 weeks in October (don’t know how old embryo was because it was already gone before I could get into the ultrasound) and just lost one this month when I was 9 weeks but embryo only measured 6 weeks, took miso to speed up the process.

We had conceived naturally but this clinic helped me through this second pregnancy. They did blood tests and said my thyroid was too high and progesterone and vitamin D were too low, they put me on meds for those. My husband and I got genetic screening and we don’t have any overlapping recessive genetic disorders.

What other tests should I expect at this point now that we lost the second pregnancy? I’m starting to wonder if we should try IVF.

I wish someone would have explained this to us before we fertilized our eggs! I’ve had two miscarriages (12 weeks and 7 weeks) and now going down the rabbit hole wondering if it could be due to sperm fragmentation!

We started IVF due to MFI all aspects were very very low, the doctor even commented after our retrieval and fertilization “how hard it was due to the sperm”. I feel like something is causing the miscarriages, we transferred 6 AA embryos and ended up losing them. I have an appointment on Monday with our IVF doctor and wanna test for everything but just really have this on the back of my mind, since we still have 3 embryos left

Any advice ❤️‍🩹

Hi!

I need advice about timing of CD138 / endometrial biopsy after miscarriage.

I recently got my first period back after a miscarriage, and I’m confused about when people usually do a CD138 endometrial biopsy.

Some doctors seem to recommend waiting one full cycle after the first period returns, then doing the biopsy in the following cycle. Others seem to do it right away in the first cycle after bleeding returns.

For those who had a miscarriage and later did a CD138 biopsy for chronic endometritis:

- Did you do it in the first cycle after your period came back? I am afraid of false positive results.

- Or did you wait one full cycle and do it in the next one?

- What cycle day was it done?

- How long after the biopsy did you get pregnant?

- Did that biopsy cycle feel “lost” / were you told not to try that cycle?

I’d really appreciate hearing real experiences because timing seems different everywhere.

Thank you.

Hi all! Looking for some suggestions about Factor V Leiden. I’ve had two miscarriages in the past 6 months. The second confirmed Trisomy 16, the other was untested but assumed chromosomal due to it being so early. I had my full RPL testing done and the only significant finding was positive for Factor V heterozygous mutation. My OB is unconcerned and says that i should avoid estrogen based BC in the future but otherwise no mediation is needed for my next pregnancy. Basic research indicates that aspirin is ineffective against Factor V related clotting.

Has anyone else had this finding in their RPL workup and what did your doctors suggest for your next pregnancy?

The other finding was that my AMH is 7.2 ng/ml which seems very high and I’m now concerned about having PCOS despite no other symptoms. My doctor similarly indicated that this is not something to be concerned about.

I am 30, almost 31 with no LC.

My husband and I have experienced 1 chemical, a blighted ovum, and ectopic pregnancy. We went to a fertility clinic after the ectopic and did RPL testing, everything came back normal. We decided to try IVF because my insurance covers one cycle. I have low AMH so we only got 2 euploid embryos, the first transfer was successful but ended up in a miscarriage around 6 weeks. We just had our second transfer and it failed.

How do you go back to TTC naturally when you really hoped IVF would be the answer? Has anyone gone through this, and if you have, what was your plan after giving up on IVF? I’m 35 and I feel so worn down and discouraged. I’m tired of the losses and I just can’t believe we’re back at square one after all of this.

35 y/o (turning 36 later this month), my husband is 1.5 years younger than me. I am a normal weight, eat healthily, and have an active lifestyle with an active career getting 10k steps per day at least and exercising 30-70 minutes on most of my off days. I have Hashimoto's and my antibody levels are controlled with 4.5 mg naltrexone q hs. My thyroid labs are also in good range with 30 mg NP Thyroid aned 5 mcg Cytomel daily. I am also homozygous for MTHFR mutation C677T. I was diagnosed with moderate to severe dry eye by an optometrist in Nov. 2024 and I found out in February that I am anti Ro SSA Ab positive so I probably have Sjogren's though no official diagnosis (awaiting rheumatology appointment). ANA negative. I also have very high EBV antibody levels without active infection. My EBV Nuclear Ag is beyond what Labcorp can read at >600 units/mL and my EBV VCA was most recently 176 units/mL down from 190.

I got married in November 2025 and I became pregnant on our honeymoon. I found out at 5 weeks at which point I had blood work at that point and my progesterone level was 8.6 ng/mL and my homocysteine level had nearly doubled from where it had been pre-pregnancy to 13.1 from 7.3 two months prior. I knew at the resulting of this blood work that I probably would not be having a pregnancy that carried to term, became fixated on missed miscarriage, and ended up having a missed miscarriage that would found at my first OB appt/US for confirmation of pregnancy at 10w2d. They said the embryo stopped growing at 8 weeks based on size. I did 3 doses of misoprostol over the course of 2 weeks and continued to have retained products of conception and required suction curettage on Jan 27. I got my period back a mere 13 days after the D&C. I had all symptoms associated with my typical periods. I purchased and utilized an Inito device to confirm my hormone levels and that things were proceeding as expected. I had an LH surge on Feb. 23 and had a positive pregnancy test 10 days later. Since I had low progesterone with my first pregnancy, my functional medicine provider prescribed me 200 mg vaginal progesterone ovules to be used nightly starting 3 days post ovulation. I didn't start them until 6 DPO. At 10 DPO, my progesterone level was 33.5 and HCG was 41 mIU/mL. I couldn't do repeat blood work in the recommended time frame since I left for vacation the next day but had the bloodwork when I returned 12 days later and my progesterone was then 35.5 and my HCG was 7648. It seemed indicative of a robust pregnancy and I was feeling positive. I requested that my first US for confirmation of pregnancy be at 8 weeks due to my loss of my first pregnancy at 8 weeks, and the US tech said my embryo was measuring 8 weeks with a heart rate of 110. Due to my history of loss, the provider wanted me to have a fetal HR check the next week. At that appointment yesterday (9w4d), the embryo was measuring 7w4d and no longer had a heartbeat. I am scheduled for a D&C on Monday since misoprostol was ineffective for me and I have no signs of miscarriage and continued pregnancy symptoms.

I am feeling confused, betrayed by my body, and wondering if anyone has any ideas or suggestions. I feel like I do everything right and everything to help myself as best as possible. My OB is referring me to a rheumatologist to address the untreated Sjogren's as they seem to think my autoimmune issues are what it causing the recurrent miscarriages. I had chorionic villus sampling sent for pathology with my first D&C but I was in the 0.1% who gets no results, nothing grew, I guess it was a bad sample. I saw the local high risk group after my first loss and they were basically like, "Why are you here? Keep taking the low dose naltrexone, there is absolutely no reason to stop it. We don't need to see you again." My friend is going to get in touch with a different doctor at the same high risk OB group to try to get me in with the doctor that helped her have a successful live birth of a healthy child after recurrent miscarriages. It seems that I need to be on Plaquenil and probably Lovenox. What else should I do or ask for? I am going to ask my functional medicine provider to order blood work for anti phospholipid antibodies. What else? I appreciate any and all insight. My husband and I want a family and I would love to be able to carry the pregnancy myself and I also don't want to be reckless with life. I am considering the possibility of trying one more time myself and if it is unsuccessful properly medicated and monitored, I will consider the possibility of hiring a gestational carrier.

I take a long list of supplements and have reproductive acupuncture weekly.

TL;DR: I have had back to back missed miscarriages that both stopped developing at about 8 weeks and were both found without a heartbeat at about 10 weeks. What can I do to help my chances of a healthy pregnancy? I have Hashimoto's that never led to out of reference range TSH despite nearly all hypothyroidism symptoms, homozygous MTHFR C677T, very high EBV antibodies without active infection, positive anti Ro SSA antibodies, and likely have Sjogren's without an official diagnosis.