I was thinking of making a list of antidepressants from best to worst. I’ve been searching online for people sharing their opinions and saying which antidepressant worked best and worst for them. Right now I’ve been on clomipramine for three weeks, so we’ll see what happens later.. :D
Anhedonia is one of the core symptoms of major depression, as we know. For you, if you remember, life with anhedonia and life without anhedonia, what were the main things that affected your life? When textbooks say lack of interest what does it mean? Can it be lack of interest in intimacy, relationships, marriage? Or is it just lack of interest in daily life activities?
I have MDD with anhedonia. I have lack of taste in foods, lack of interest in anything related to relationships, social activities, lack of joy in general.
I currently on Venlafaxine 225mg, Amoxapine 200mg, Trazodone 50mg and Prazosin 2.5mg. Hoping to find a medicine combo that brings my life back to normal.
Has TMS been successful for anyone? I hear mixed things but considering it in the near future.
M35, For years im on trial and errors with antidepressants, just nothing.
I've never felt what does focus means, 24/7 scattered brain and tons of thoughts at the same time, can't finish anything or complete a task, extremely easy to be distracted and terribly non available memory.
which completely affected my life so bad, i can't learn or memorize anything, can't study, working in a terrible place because i couldn't find better due to my issues and im the only one at work that always distracted, never completed a task and the only one that always forgets and makes mistakes, even the simplest math i can't do.
Tried the first route, lab tests are fine, vitamins, minerals, herbal extracts and amino acids but nothing worked.
Doctors just say its some kind of anxiety and stress.
Then finally went to psychiatrists, started with SSRI'S, SNRI'S and Tricyclic antidepressants and to be honest, they just killed my last cells of emotions and made me eat more, That made me hold still from 2019 till now and made me feel so depressed all the time and this loop cycle is still running til now.
Trials and errors with Fluvoxamine, fluoxetine, Venlafaxine, olanzipine, welbutrin, paroxetine, Cymbalta and Clomipramine.
Lastly im on 20mg Prozac and 150mg Clomipramine.
Doctors just says medications needs time and i hear that from 2019 to this moment.
Tried to research and to see what's going on and god knows how hard that was and found ADHD which i can relate to 100% of it (ADD) Thanks to the internet and reddit.
Went to psychiatrists again and what I've found that where i live ADHD is something like witchcraft and got terrified from doctors warnings from using stimulants.
But i don't know what to do to help myself, I'm a father of 2 kids and i don't want to complete my life like this.
Please advice, I've an appointment with my psychiatrist in the next week and don't know what to do
I tried pretty much all legal and illegal treatment options I could avail, including ketamine, MDMA, psilocybin etc.
Nothing works quite like a good NSAID. You can't take it regularly but oh man, this shit fucks. Its effects are subtle but it really pours life into my dead soul for a while.
Psychedelics and ketamine have similar or sometimes better transient effects but they don't seem surprising based on their MoA but NSAIDs lifting my depression is hella interesting.
Maybe it's neuroinflammation all the way down.
Did anyone have similar experiences with NSAIDs or other pain killers(excluding opiods)?
I know that Clomipramine is a TCA antidepressants but it is also the most potent SNRI's available on the market , after being on 75mg for 4 weeks , bumped to 112.5mg last week and my energy levels are finally back to baseline ( I had sever chronic fatigue due to my depression ) , my anxiety is also very manageable and my thoughts are so quiet for god remembers how long ... , my derealization is much better too
All in allw Clomipramine is a very succes to me after trying over 20meds over the course of 5 years .
I am also on olanzapine 5mg ( instead of Seroquel 300mg wich made me a zombie 24/7 ) , olanzapine is really good so far at 5mg , Depakote 500mgx2 , and lastly Tianeptine 12.5mg x 3 a day and 50mg Amisulpride for major depression .
This combo is really bringing me back to life after years in a dark hole ...
Whats ur experience guys with clomipramine ?
Looking back now, I feel silly for letting all the negative SSRI hype on the internet get to me. I agree side effects are always a consideration, but when the medication works well, it can make an incredible difference.
I’m taking Escitalopram these days and my stubborn social anxiety has almost entirely melted away.
Why do people think depression is treatable, when the reality is that you will feel awful forever. Like, all the "treatments" that are not psychiatry are just tortures imo. Nothing ever gets easier or helps with depression Iong term. Maybe apart from having depression i am just a loser with congwnital defects. I wish people in my life would just stop lying to me and accept that this is not a life worth living. I want to die
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It's like an alien language to me. Now granted I've been actively suicidal for a number of years and I would like to just turn the lights off so to speak. My current treatment program has greatly reduced that aspect of my personality.
The problem is I do not like myself and I don't have any sense of an inner person. Who I am is something I can't answer, I don't have much sense of an inner dialog. I have people who care about me, and I just don't get it. They would all be better off if I were not present, but for whatever reason they take some joy from my presence.
At best I can "not think" about myself and just do a thing, but thinking about who I am, what I do, where I've been, what I've done... I just don't care about that guy. Don't like him.
So explain it to me like I'm from another world because I can't wrap my head around it.
Like the title says. My new psych wants me to go off of Wellbutrin even though is the only med that ever did anything for my depression and helps my SCT and executive dysfunction tremendously.
The reason he wanted me to go off of it was because of the side effects it has started give me. These side effects are clearly related to its noradrenergic effects and those side effects are frequent thirst, frequent urination, dry mouth, dizziness, vertigo , heart palpitations, rapid heartbeat, hot flashes, burning sensations, headaches, insomnia and jitteriness. Even though I told him that Wellbutrin is essential for my daily function and helps my brain fog, mental clarity, energy, motivation and depression, he still wanted me to go off of it. He told me straight out that I should start reevaluating if this med is really necessary for me after being on it for a long time now and because of the side effects it’s giving me.
When I used to take it with Prozac a while ago. I was at the exact same dose and had almost none of these side effects at that time. The anxiety and insomnia weren’t there when I took it with Prozac. But the reason I removed Prozac in the first place was because I felt it was making my SCT and executive dysfunction worse. And removing Prozac made energy, motivation, functionality and productivity better. But at the cost of getting now chronic anxiety and insomnia and these other side effects that won’t go away. I don’t know if Prozac masked these side effects all along or if it was something with the combination that made it work better for me. Or if Prozac balanced out my neurochemistry overall. And I have thought about this for a long time now if reintroducing Prozac all over again is the only solution to get rid of my issues.
So my new psych won’t really listen to me and hear me out. I feel like he doesn’t take me seriously and doesn’t want to talk to me about how we can resolve these side effects in the best way possible without needing to remove the med completely. Because Wellbutrin is important for me and if I really didn’t get any benefits from it at all I would’ve stopped taking it a long time ago. I wouldn’t keep taking a med that gives me these side effects just for nothing. But it just seems like he doesn’t understand me and it’s not engaged or interested in helping me out at all.
I would really like to hear your thoughts and opinions about this. I appreciate all the advice.
M35, For years i was suffering from GAD, Agoraphobia, Depression, unavailable focus with scattered thoughts and can't learn or memorize anything.
In the beginning doctors prescribed fluvoxamine then paroxetine then Venlafaxine then olanzipine and now 20mg Prozac with 150mg Clomipramine at night.
These trials and errors with meditations and dosages took years from 2019 to finally settle on 20mg Prozac and 150mg Clomipramine but finally able to get a job.
But i couldn't focus, fatigued most of the time, can't learn or memorize anything, still depressed, self esteem destroyed, no confidence, stutter sometimes, even couldn't do the simplest math without calculator and terrible social skills..
Last 2 years i discovered reddit and start researching, tried tons of supplements and felt nothing, vitamins, minerals, herbal extracts, amino acids just nothing worked out the blood work came fine on papers.
until by luck got a 500mg Citicoline from a local pharmacy and luckily felt something.
finally started to talk with customers, some motivation and energy, 2 weeks later got some Armodafinil 150mg and Quatrefolic folate and my brain switch turned on.
Talking alot with customers, extroverted, confidence through the roof, playing with my kids, calm and relaxed.
Yes i felt my heart a bit racing, some headaches,
Maybe my focus is still not there and didn't feel anything positive regarding memory and learning.
But this is like a miracle to me, specifically Armodafinil.
So i came here to ask for more help please,
Did doctors prescribed the wrong antidepressants for me all these years SSRI'S, SNRI'S and Tricyclics.
Nothing came even close to this last experience.
I've an appointment with the psychiatrist soon but i don't know what to say.
Sorry for my terrible English.
Blunting and anhedonic effects of SSRIs is theorized to be from activation of the 5ht2c receptor, so wondering how significant the 5ht2c antagonism is from prozac and if it's actually dopaminergic and helps with anhedonia?
this may sound like a stupid question but I’m genuinely confused. I’ve been diagnosed and medicated for depression/anxiety for around 5 years and taken 8 different medications for it so far (Prozac, Zoloft, lexapro, wellbutrin, Effexor, cymbalta, buspar, Ritalin) Personally, almost every single one of these meds has made me feel absolutely no different, but I have a hard time tracking and understanding my emotions so I could also be ignoring it Ig. However my depression is very episodic and changes quickly, so I never really know if me feeling better/worse is cuz of the medication or if it’s just another episode. There has only been one medication that I ever felt actually helped (lexapro) and it was a very slight difference for a very short time. My question is, how do people know that a med is helping or hurting them? What changes do you notice? How did u know it was the right fit? Im so tired of this continuous loop of trying things just for nothing to happen.
Uh.. so im off my meds because they hurt me a lot, and now im like super in the mood all the time like ive never been this way before… ive never been abke to feel this way until now, is this normal?
I don't make enough money.
I need a second job.
No SO doesn't want me to take a second job I'll be too stressed.
I will upgrade my education.
SO says it's a bad choice because it'll be hard and I will be stressed.
I suggest saying fuck it all and quit the application process.
SO says no, nothing good comes from quitting.
I can't fucking take it guys. I know all my decisions in life are shit because I'm fucking broke, poor and depressed. I chose a career that I'm barely making ends meet and I wasted two years of college and a decade of my life on this fucking job. When I try to take any action my SO tells me what a shit situation I'm creating, but I can't stay still. Like fuck me! I know I can't do LIFE. I KNOW THIS. THIS IS WHY I WANT TO END IT BECAUSE I CAN NOT MAKE GOOD CHOICES.
Thanks honey, I get it, I'm fucked, we're fucked, everyone's fucked. Everything is hard, everything turns to shit and I am a remarkably bad human being. Life is a no win situation so fuck it, I'll buy the rope. At least I can do that right.
Fuck me.
Hi guys,
I have treatment resistant depression. It's resistant to all medications, therapies, TMS, ketamine, and ECT.
I was just wondering - people say that a keto diet or a carnivore diet helps. I'm not going to post in the subs that support these diets because IMO they're overhyped and the people there will be biased. However, I think posting here I might get a better answer.
Has anyone been helped by these diets? I don't want to go through the trouble of trying them but I will try it if there's good evidence of it helping. I just can't find any evidence other than personal anecdotes.
I also am on a diet lower in carbs (~100g) but it's not 100% keto or carnivore.