u/Lumpy-Criticism-2773

I tried pretty much all legal and illegal treatment options I could avail, including ketamine, MDMA, psilocybin etc.

Nothing works quite like a good NSAID. You can't take it regularly but oh man, this shit fucks. Its effects are subtle but it really pours life into my dead soul for a while.

Psychedelics and ketamine have similar or sometimes better transient effects but they don't seem surprising based on their MoA but NSAIDs lifting my depression is hella interesting.

Maybe it's neuroinflammation all the way down.

Did anyone have similar experiences with NSAIDs or other pain killers(excluding opiods)?