What compounded semaglutide side effects with PCOS looked like for me and whether the pattern is too different for each of us?
I have PCOS and started compounded sema about four months ago. Before I started I spent a lot of time reading about side effects but almost everything I found was generalized and not specific to people with insulin resistance or PCOS. I want to document what mine actually looked like in case it's useful for someone in a similar situation.
Weeks one and two: nausea that was manageable but real, mostly in the hours after injection and into the next morning. Fatigue that I wasn't expecting. Appetite suppression that hit faster than I expected, within the first few days.
Week three: nausea peaked for me here and then started to settle. This surprised me because most posts said it gets better after week two. My doctor mentioned that the insulin resistance picture with PCOS can affect how the medication metabolizes early on which may contribute to a slightly different side effect timeline.
Week four onward: nausea mostly resolved. Appetite suppression remained consistent. The constant background hunger I'd had for years started to quiet in a way that felt different from just not feeling like eating. My A1c started trending down around this point.
Scale movement has been slower than what I see in most posts. My doctor said this is expected with PCOS and insulin resistance and that metabolic markers often move before weight does. Frustrating but at least there's a clinical explanation.