So I’ve been off 7OH since late last year and I’ve gone to NA during that time and remained sober. However, I do take Naltrexone and honestly, I kept relapsing until I got on Naltrexone and now I’m over 100 days sober from 7OH. However, I’ve suffered from depression for a really long time and it got even worse when I got sober, so my Psychiatrist had me start Spravato which is supposed to be like a game changer, super effective antidepressant that is supposed to work really quickly. I’ve been on it for over a month now and wasn’t really feeling better. So I was going over my medications with my Psychiatrist, and apparently, Naltrexone blocks the antidepressant effect from Spravato so my Psychiatrist had me stop taking it and the Spravato become super effective and has helped my depression tremendously. Apparently Naltrexone prevents Esketamine from activating the mTOR pathway in the brain which is an integral part of the antidepressant effect from Esketamine. I just wanted to share this with y’all in case you are also on Naltrexone and doing Spravato for depression since I feel like depression and substance use disorder kind of go hand in hand, have a great day y’all!!

My partner and I have been accidentally projecting our consciousness into this space by accident and didn’t know how to get back. It was scary af. If anyone has any insights into how to control this experience and it not be random I’d really appreciate some advice.

Food in the belly seems to be grounding and help the experience not happen? Maybe?

No, I will not elaborate.

What’s your favorite music to listen to?

My last IV sesh was in December. I got pneumonia for like 3 months and plan to go back to my regular schedule starting next week. Before, I was going every week since I had only really just finished my induction. Has anyone taken a break for whatever reason and gone right back? I’m worried about tolerance and if I need to take a few steps back in dosage. Obviously the Dr will know what’s best but I’m worried about having a bad trip my first time going back

I’d appreciate any constructive/supportive comments on this topic. I’ve seen other posts about ketamine taking away the ability to lie to yourself. I have been experiencing this and… it’s a lot.

The older you are, the harder this hits. So many avoidable mistakes and failures of my own making.

Tried so hard in my life to appear intelligent and clever.

Realizing I cling to my childhood trauma and victimhood because it’s the most unique and interesting thing about me.

Auvelity, doxepin, and ketamine seem to be the combination that has helped me more than anything else I’ve tried since I was 20. I’m 42 now, and for the first time, I feel like I may have found something that truly works for me.

It honestly feels surreal after so many years of trial and error. I’m grateful to be living in a time when more treatment options exist.

The remaining question is whether Vyvanse is an essential part of the picture or just incidental.

Has anyone else done well on a similar combination over time? I’d be interested in hearing about your experience, especially with mood stability, motivation, and side effects.

Hey everyone,

I’ve been dealing with treatment-resistant depression and went through 6 sessions of ketamine therapy. It actually helped, but the effects only lasted around 3 months, and now the same symptoms have returned.

The frustrating part is that doctors here in India are not willing to continue ketamine treatment. They believe it only provides temporary relief and are recommending going back to standard medications instead.

I’m trying to understand:

- Has anyone else experienced ketamine wearing off this quickly?

- Did you continue with maintenance sessions or switch approaches?

- What helped you after ketamine stopped working?

Would really appreciate hearing your experiences.

My partner just stared Ketamine therapy about a month ago. I noticed two sessions ago afterwards his communication was aggressive. I asked to confirm if I needed to be home to receive a package and he replied why I was asking and called it a game. He proceeded to "argue-text" me all evening over something so minute.

Then yesterday after this treatment, he gets home and accused me of taking his medication (not ketamine, but a stimulant). I was not physically home at the time he noticed it was missing, so he called me said a few words and hung up. Not typical of him at all. When I get home he is very aggressively telling me to return his medication and how he intentionally put it there and now it's gone, etc. He didn't hear me out and declared he was done and I would be dead to him if I didn't return it immediately. He has been avoiding verbally speaking to me for over a day now and I believe has packed a bag to leave for whatever reason- his dog is also gone, so I'm guessing he out him in boarding for some time. I have watched his/our dog for weeks alone at a time.

It just seems like he is having paranoia about something that was physically impossible and somehow misremembering whatever happened with where he placed his meds.

I am not sure what to do, but feel like this is associated with the treatments. Any advice on what to possibly do here?

I have tried so many antidepressants and nothing works so I wanted to try ketamine. I am leaning towards Mindbloom because they have the injectable option (I heard the torches taste bad and have variable bioavailability).

They said most people have results in 6 sessions then may continue once a month or so. Saw some posts on here about people taking ketamine for years. Just wondering what various timelines can look like . I had liked ketamine because it was better than taking a pill every day for the rest of my life. But it sounds long term too.

Also wondering if you were able to stop your antidepressants after completing your 6 sessions.

I’m new to therapy, but not necessarily new to ketamine and would like to find the best at-home option specifically based more on the *therapy* provided.

Any feedback on this side of the equation specifically would be much appreciated!

Today is a great day! President Trump signed an executive order that makes Psychedelics legal for the therapeutic use and they rescheduled it! Amazing! 🇺🇸🇺🇸🇺🇸 carry on…

I started Joyous about a month ago and dose just got upped to 75mg daily. I am thinking about taking it every 3 days (225mg) instead. This is for two reasons, 1) It’s a pain to make time for daily floaty feeling and intention setting sessions every single day. 2) I had radiation treatment to pelvic area for cervical cancer 3 years ago and am concerned about worsening bladder damage.

My depression and chemo/radiation foggy brain have already improved so I really don’t want to stop taking ketamine regularly until I feel I’m ready to. I will have to lie about the new schedule to Joyous, though.

Has anyone else done something similar? What are any thoughts on this?

Hi, I’ve been chronically ill and recently finally completed moving states. A few months back, I had found a company that accepted Nebraska Medicaid for at home therapy. I can’t find it now unfortunately. Any one with any leads for at home treatment that accepts Nebraska Medicaid? Thanks

Did my first session at a Dr's office. I can say it was an amazing experience and I learned so very much about myself.

***HOWEVER*** as a audiophile I'm deeply moved by music. I chose songs that are chill and vibey but not engaging. I used my basic spa mix from when I was an LMT. I was *really* looking forward to using some of my favorite songs (like The Gaels and Anything by Slow Meadow). Unfortunately, they really pulled me out of the experience. I really enjoyed hearing the songs at a different level (more undertones and intricacies) but it certainly pulled me out. I'm glad that most of the songs were randomly general spa stuff.

On the flip side of that, Weightless by Marconi Union has been medically proven to help lower the heart rate for anyone anxious.

Also, make sure you put a volume regulator in your music. Nothing screams **HEAL** like having the Gaels force fed into your brain at large disables.

looking at this for an option since spravato didn’t work out and i can’t afford the infusions…this is for mental health and chronic pain! thank you in advance! 🩷

I have dealt with severe depression, OCD and anxiety for over 10 years. My depression has only gotten worse. I have done all standard treatments and therapies, med augmentation and off label meds. I have done trauma therapy, ERP, ACT, CBT, DBT, somatic therapy, vagus nerve exercises, yoga. A bunch of things I have not listed here. I have done intramuscular ketamine assisted therapy. About 14 ketamine injections and therapy sessions. I have tried like 10 different supplements. For the past few years I have abused any substance I was able to get my hands on. Alcohol, Kratom, phenibut, nicotine, caffeine, DXM. I need it to be clear that I only started abusing these substances a few years after starting to get treatment.

So, all this led me to kind of obsessively research interventional psychiatry. ECT is the most effective treatment that is more or less widely available.

I did consider standard TMS but felt that the response rates were not worth the effort. Accelerated TMS on the other hand has very good response rates and potentially even better response rates than ECT. The problem being that accelerated TMS is not covered by insurance and so it would be self-pay. The place near me that does something similar to SAINT TMS is $9,000. The only way I would be able to do that is by starting a go fund me. Even if it works, it's likely going to have to be done again sometime down the line when the effects fade. It may be possible that my insurance would cover theta burst TMS which the timeline is somewhere in between accelerated TMS and standard TMS, but it does not include the fMRI guidance.

Next week I have an evaluation for ECT. They do both ultra brief pulse and right unilateral ECT. I want to hear about your experiences with ECT and if you did ultra brief pulse alongside bilateral or unilateral ECT.

I am very wary about ECT, but I am unsure if that is a result of my severe anxiety.

I have also considered something like VNS. Even though its moderately invasive and requires surgery, it still feels less scary than ECT. Although it takes a long time to start working.

I am lost on what to do because I need treatment soon or I will continue to abuse substances until they kill me.

TLDR
If you have had ECT what is your experience with it? Any long-term cognitive effects? Did you get bilateral or unilateral ECT? Did you get Ultra brief pulse ECT?

If you have had the VNS surgery, how did that go for you?

What other options might I have at this point?

spravato kinda helped but the ubers are getting pricy. not sure i can afford iv anymore. gonna ask my psychiatrist if she can do this for me. has anyone had any success? thanks in advance! 🩷

do you follow some specific integration therapists, coaches, clinics/communities/ companies? (not the luxury millions $$$ retreats)

Hello guys,

I (22f) will be receiving ketamine infusions in a few weeks for chronic pain in my right ribcage. The pain is constant, sometimes really severe and resistant to every medication tried so far (even opioids). I’ve had this pain for over a year following a stomach infection but after countless tests no doctor was ever able to diagnose me, so it’s supposed to be some type of central sensitization. Because of the constant pain I have also developed anxiety, depression and medical trauma. I am looking forward to receiving the infusions, however I am scared because any other treatment I’ve tried so far was unsuccessful, so this kinda feels like my last option. Is there anyone out there who was in a similar situation to me and has seen success with ketamine? What was your experience like? Any advice?

Thanks in advance :)

I'm looking for a specialized pain clinic or anesthesiology-led center in the Austin or San Antonio area that performs long-duration Ketamine infusions for chronic pain/central sensitization, not a 30-45 minute mood protocol.

If anyone could help it would be greatly appreciated.