r/zoloft

🔥 Hot ▲ 93 r/zoloft

Is this what other people feel like all the time?? 🤯

I have been on Zoloft for about 10 months (started postpartum from OB). started at 50 mg and switched to 100 about 8 weeks ago with my original psychiatrist. And… over the last 2-3 weeks I feel so… functional??? Happy go lucky??? And not anxious??? And excited to do my job every day??? This is wild, I keep questioning whether it’s normal/ sustainable or if I’m going crazy.

I’ve been on almost every other antidepressant over the years and nothing else made me feel like this, like I thought some of them “worked” but had no idea how much they were not.

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u/npslvr — 20 hours ago
▲ 14 r/zoloft

SUCCESS STORY - 16 weeks at 100mg

Before I go into the detail, I have attached a visual of my timeline. Between starting 50mg and 100mg, the journey was remarkably similar, with peaks and troughs hitting almost symmetrically. 100mg did the trick after 16 weeks on that dose, and my story is as follows:

I’ve gone back and forth about posting this, but if it helps even one person who’s in the middle of it right now, it’s worth it.

In May 2025, I restarted Sertraline after coming off it for a year and seeing my intrusive thoughts and depression returning. I was started on 50mg, and I kept a weekly diary of how things went, mainly because I was trying to survive it, and I needed something to hold onto.

I’m not going to sugarcoat it; the beginning was absolutely brutal. The first couple of weeks were some of the lowest I’ve ever felt. I barely slept. My anxiety was constant and overwhelming. My mood was so low it felt heavy just existing. I remember thinking, what if this is just me now? What if I’ve broken my brain? I had the same awful thoughts going round and round in my head constantly. I honestly thought I was losing my mind. I stopped working, stopped getting out of bed, stopped seeing people. I was existing, but that was it. I thought my life was effectively over.

That’s the scary part, when you’re in it, it doesn’t feel temporary. It feels permanent. Slowly, there were cracks of light around Week 4, I felt a slight shift. A slightly better night’s sleep. A moment of calm. A conversation where I felt a bit more like myself. Weeks 4–6 gave me glimpses that things could improve… but just as I started to believe that, I got knocked back down again.

Around week 7, I dipped hard. The anxiety came roaring back, the low mood followed, and it felt like I was right back at the start. That cycle of feeling better, then worse again messes with your head more than anything. You start to lose trust in your own recovery, and it’s so cruel.

But this is what I wish I’d fully understood at the time, setbacks don’t mean you’re back to square one. They’re part of the process, even though they feel like failure – if you have had some good days, hours even, the medication is working.

By week 10, I had my best week – I felt normal. Like properly myself again and thought I’d cracked the case. I felt the medication had settled and levelled after Week 12 but still didn’t feel right. I made the decision with the advice of my doctor to increase to 100mg.

The first couple of weeks after increasing were terrifying. The anxiety was intense, the intrusive thoughts were constant, and there was a real sense of hopelessness that crept in. I remember having moments where I genuinely couldn’t see a way out of how I was feeling. Even though you know you’ve been in the hole before, and you know it’s because you’ve increased your dose, it just doesn’t stick. I was looking for constant reassurance this was normal, and crashed back to day 1 levels.

But even in that, there were tiny signs, a calmer evening, a clearer head for an hour, and those moments matter more than you realise at the time.

Again, around weeks 4–5 on the new dose, it was like everything settled. Not overnight, but gradually. The noise in my head quietened. The anxiety loosened its grip. I could think clearly again, and I could enjoy things again.

There were still dips after that, again around weeks 6–8, and again later on, and each one was scary. But the difference was, I had evidence now. I’d seen myself come out the other side before and that’s what got me through.

The magic Week 12 came and went, and I was still up and down. By Week 16, I felt completely and totally normal. Like nothing could bother me, and those thoughts that used to haunt me daily were a mere memory, and nothing was sticking like previous.

So if you’re reading this and you’re in the thick of it, especially those early weeks, or a bad dip, I know it can feel unbearable, but it isn’t forever.

I had days where just getting through the day felt like a win. Nights where I couldn’t switch my mind off. Moments where I genuinely believed I’d never get better and thought I’d lost my mind.

Please don’t judge your progress day by day, it’s way too up and down. I found looking week by week was much more productive. Hold onto the small improvements. They’re signs that things are shifting, even when it doesn’t feel like it.

You people are incredible. Battling through the horror of mental health daily, and coming here to help others out. These groups were my life whilst I was in the thick of it, so it’s only right to come here and offer some support to others.

If anyone is going through something similar and wants to talk, my messages are open.

u/KentishPlover10 — 7 hours ago
▲ 5 r/zoloft

My psychiatrist said Zoloft won’t do much to help me.

I met with my psychiatrist a few days ago and she said that Zoloft won’t do much to help my specific problems. I went to them because I feel like I have social anxiety, but now I’m questioning what the problem is. I’m really afraid that I’ll always be a socially awkward person who has no friends or love life. She said forcing myself to talk to people will help with Zoloft, but how can I do that when I can’t keep a conversation going without feeling uncomfortable and/or tiring.

My question for anyone reading this is did Zoloft help you with socializing? Did it make you more confident in social settings or possibly give you more of an urge to socialize?

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u/Spiritual-Award3742 — 4 hours ago
▲ 5 r/zoloft

W Zoloft

Hello friends!! Ive been on the lowest dose since February and added Wellbutrin in March. This is the holy grail combo. I feel so sad for the girl I was before medicine. I knew that I felt bad but I really invalidated the fact I was severely depressed until I was at my worst. I LOVE life now. I love people, plants, the sunshine. I love it all! I’ve been able to go to the dentist for the first time in years, build a community of people I love again, maintain a clean and healthy life. It is so worth it! For me, it’s only about $0.15-0.44. Super affordable.

The dizziness subsided after two weeks so really try to stick it out for the full effect 4-6weeks in.

I hope this being confidence to anyone reading and wondering if this is for them. I spent a month reading this subreddit before finally seeing a dr(:

Good luck🫶🏻🫶🏻🫶🏻

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u/Kaymacfan_ — 5 hours ago
▲ 1 r/zoloft

When did you notice an increase in motivation, drive, and confidence with less self-doubt?

I’m currently on day ten. Perhaps I feel a bit better in terms of mood stability, and I’m experiencing less negative/paralyzing intrusive thoughts.

Although, I just feel absolutely demotivated and I’m struggling to believe in myself and have faith in my abilities.

I’m just feeling quite self-conscious in general, tired, and still mentally foggy from months of feeling down.

I know from experience - this negative voice inside my head IS depression. It’s also from complex trauma, too.

When did you start to finally feel better, where you’d say it was noticeable? When did your spark and belief in yourself return?

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u/adhdbeast101 — 1 hour ago
▲ 11 r/zoloft

First week on Sertraline

Hi All

I am in the UK.

I have started out on (Zoloft) Sertraline, as it's called here been on it now about a week 50mg.

I have been having some side affects.

First, 3 days all ok, then on day 4 had a massive panic attack and wretched insomnia has set in. It’s like I am wired and body is afraid to sleep. I just can’t drop off, I even took 2 Nytol tablets and got about 2/3 hours, but that is it. I have had to take a few days off work now.

Another symptom I have is that it’s like a switch has turned off my groin down below. No erections at all, peeing has changed, now have hesitating waiting to go, also going for number 2 have to strain a bit more. Things feel different in that area.

Also I also have added nerve sensitivity now, in my arms and legs, though I had Allodynia previously, just wasn’t this bad prior to starting.

Are these common side effects, I understand with SSRI’s you may have to go through a tuff period, to see the light as such, but didn’t think it would be this bad.

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u/Nesty1760 — 11 hours ago
▲ 1 r/zoloft

Up to 50 Zoloft

I was on 37.5 now just up to 50 2 days ago ! Does it make you really tired when up a little ? Does it go away ?

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u/Over-Air-2231 — 2 hours ago
▲ 1 r/zoloft

3 weeks since my last dose. Having the worst withdrawal symptoms at this point. Just be patient?

I tapered slowly off 50mg. That part went fine. But now 3 weeks since my last dose and the brain zaps are horrible. Looking for similar experiences.

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u/MiddleTomatillo — 2 hours ago
▲ 1 r/zoloft

Blood flow feeling in wrist

So I’ve been on 50mg for 7 weeks. Around the time I started or a week or two after, I’d started feeling a buzzing like blood flow on my right wrist. To the side of where you would take your pulse. This was a constant flow feeling, like a whooshing thing. I didn’t equate it to the Zoloft. I figured since I’ve been losing weight and also hydrating more, maybe my veins became more pronounced. This was only in the right wrist. Fast forward to yesterday, I had a minor procedure no where near my wrist. (The nurse felt it while she was putting in the IV and said it was weird). Anyways I didn’t take the Zoloft yesterday. Wake up this morning and the only side effect to missing a dose is that the whooshing is gone!! Like not even there anymore. Took my dose at noon and waiting to see if it returns. Anyone have anything similar?

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u/Playful-Check-4968 — 2 hours ago
▲ 2 r/zoloft

Alcohol and Sertaline?

I have been on Sertaline for over 2 years. I went from 50mg down to 25mg now and i have been on 25mg for 6 months now. I do drink on occasion on weekends with my boyfriend for fun and i am starting to notice that i get drunk way faster than usual and i blackout and i cant remember the night. I am not downing bottles either, usually its 2 bottles of wine between us, some shooters or a small bottle of tequila(obviously we dont drink it all in the same night) i am not looking for a rant about how i should not be drinking alcohol but i am 26 and drink for fun on weekends, just looking to see if anyone else has experienced anything similar or anyone elses experiences :)

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u/Wonderful-Dealer9344 — 5 hours ago
▲ 5 r/zoloft

What have you learned about yourself while being on Zoloft?

Has being on Zoloft showed you your causes of anxiety, helped you to analyze your thoughts, and find a solution that works for you?

I am currently on 25 mg but don’t want to be on it long term and was wondering if people have learned more about their anxious habits since being on the medication.

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u/miastar_123 — 10 hours ago
▲ 13 r/zoloft

Anhedonia?

I, 25m, have been on Zoloft 50mg since July 2024. It really helped with my anxiety, but now that I’m getting older I have a general sense of not wanting to do anything. I don’t want to go out, or hang with friends, play video games. Literally all I want to do is lay in the bed. And I used to not be that way. Has anyone experienced this before and if so, how did you deal with it? I talked to my therapist about it and she said it’s a “personal decision”, but that doesn’t help me much.

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u/No-Adhesiveness-7896 — 22 hours ago
▲ 2 r/zoloft

Anyone with anxiety who felt a big difference being on 75 vs 50?

Anyone had a positive experience with upping to 75 after being on 50 for quite a while? Or do I need to keep increasing to 100?

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u/DannZw — 10 hours ago
▲ 5 r/zoloft

Zoloft side effects

Hi I’ve been on Zoloft for a month now.

25mg for 2 weeks and then increased to 50mg, it’s been 2 weeks after dose increase.

Since I started it I had a shaky feeling and it got worse after dose increase. I feel trembling from the inside. I have less energy.

I feel dizzy

And very less mentally sharp.

And two days ago I started having slow digestion. It’s weird, my stomach takes a long time to empty.

What’s confusing me is that on the first week of 25mg I was feeling fine. Except for some night adrenaline dumps that were tolerable. It made me happier instantly and gave me energy. Then it suddenly made me worse instead of better.

I don’t know if I should wait bc it’s still early to assume.

Can these side effects vanish with time?

Did anyone experience anything similar? And got better with time?

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u/Intelligent_Cap6394 — 18 hours ago
▲ 7 r/zoloft

Newbie

I resisted this for a long time. Decades. Severe chronic insomnia since graduating college with panic attacks. Life was done for me. I just started this med and for the first time in years have not cried all day. Has anybody else suddenly stopped sleeping, no pun intended, overnight? A switch got flipped and no doctor has ever been able to tell me why. How does this happen to a seemingly healthy college student? Has this been anyone else's experience? Has this med helped you and how? Idk why everyone seems to be depressed, anxious, and medicated. What's going on with humanity? I have no ruled out spiritual attack btw as I'm a believer.

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u/Desperate_Lime_443 — 24 hours ago
▲ 2 r/zoloft

Beta blocker

I’m on day 3 and my blood pressure is too low for my liking. I am on Metoprolol extended release at the lowest dose and just got my blood pressure back to the 110 area and since starting Zoloft my blood pressure is back in the 80s and 90s. Will this eventually even out in my system?

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u/TwoFlimsy3386 — 11 hours ago
▲ 1 r/zoloft

Changed brands now i feel worse

So I started my second month on sertraline now , my first supply was from a brand called crescent i was starting to feel a little better and now this time the pharmacy gave me a brand called flamingo and i took its first dose yesterday and i have been feeling much worse with a massive headache and wasnt able to sleep properly at all and have a migraine like headache , i have migraine too its not as severe as an actual one but its similar

Is this normal? Should i contact my doctor?

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u/DepressedCocaine — 7 hours ago
▲ 3 r/zoloft

Ear ringing / tinnitus??

When I started sertraline the ear ringing started at some moments. But it went away. Now a couple weeks later my right ear is a constant Eeeeeeeeeeeee. Non-stop every day :(.

I am taking sertraline 3.5 months, 11 weeks on 100 mg.

I take sertraline also for hyperfocus, but with this new gift it only gives me more things to focus on lol

Does this ever stop????? Any advice? Somebody can relate?

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u/Cheesecake2401 — 17 hours ago
▲ 3 r/zoloft

Week 6

I just hit week 6 on Zoloft 150mg and I still have physical anxiety which is why I hopped on Zoloft in the first place to fix. I know it can take up to 12 weeks to fully feel the benefits, but I’m just wondering when do you think it will hit for me or when did it start working for you?

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u/Shisavage21 — 22 hours ago
Week