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r/HairlossResearch

Image 1 — Adrenal PCOS hair loss, insomnia, hypoglycemia…please, help…
Image 2 — Adrenal PCOS hair loss, insomnia, hypoglycemia…please, help…
Image 3 — Adrenal PCOS hair loss, insomnia, hypoglycemia…please, help…
▲ 5 r/PCOSloseit+2 crossposts

Adrenal PCOS hair loss, insomnia, hypoglycemia…please, help…

I am 34/F and I have regular menses (between 28-32 days on average). I am struggling with adrenal PCOS and insulin resistance. I have also dealt with hirsutism for about 10 years.

I have tried everything to help my adrenals including switching my job position a year ago. I suspect I was going through adrenal fatigue and burnout in my previous role for three years and was not nourishing or hydrating my body properly. I began to experience the dreaded 3 am wake ups in a panic and my cortisol was very dysfunctional at that time.

Fast forward a couple of years and my body still feels stuck. My problem is no longer high cortisol I’ve tested and my levels are normal. I did cheek swab and urine tests. But my issue is high DHEAS. The last time I tested it was at 238. Insulin was at 22.

I experience massive amounts of hair loss and still can’t sleep past 3:30 am no matter what I do.

In the past I’ve tried Ashwaganda to hep regulate the adrenals as well as reishi and both gave me more anxiety so I had to stop taking.

I’m currently taking:

- Myo-Inositol

- omega 3,6,9

- Zinc

- freeze dried organ cells (because I’m also low ferritin)

- Vitamin D

I’m trying to eat balanced meals and move my body, but I am so discouraged.

Is there anything that has worked for any of you with adrenal and insulin resistance specific PCOS? I need to stop this hair shedding but I don’t know what else can support my adrenals to make this happen.

Thanks for your insights.

u/Fun-Stay1117 — 4 hours ago
▲ 2 r/HairlossResearch

cyp19a1 promoter I.4 and it's role in AGA

Has anyone else looked into this?

Seems to me that if there was a way to specifically upregulated cyp19a1 promoter I.4, it could lead to an increase in aromatase expression within the scalp and thus reduce the DHT load on the hair follicles.

This seems like a pretty big deal in terms of AGA.

Cyp19a1 promoter seems to be downregulated in individuals with PCOS, and there has been several papers looking into the similarities of males with AGA and females with PCOS. Low shbg, low fsh, metabolic dysregulation, etc.

High cyp19a1 promoter I.4 expression could also potentially explain why some individuals can endure a high androgenic environment through the use of PEDs, yet not experience any hairloss (or at least very little of it).

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u/Mokilolo — 8 hours ago
▲ 2 r/HairlossResearch

Thoughts on L'Oreal Professionnel's Serioxyl Advanced?

For thinning hair (due to vitamin deficiencies) and clogged follicles on scalp (sebum plugs I think?). Will this shampoo help my hair become stronger at the roots? I'm sure my hair loss is mainly caused by it being very thin and brittle due to vitamin deficiencies, as I mentioned, and it's just easy for it to fall out. Why do some people not find this shampoo helpful? Should I expect it to not work for me either, given the cause of my hair loss?

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u/alqaji — 24 hours ago
Week