I have heard some great stories and results with GLP1. Just wondering how long y’all have been on this med. I know Ozempic has been around for a while. Seems like most are saying about 8 months. After the major loss do you go to micro dose?
What’s the best way to sleep through as much of the bad side effects as you can?
I'm really wanting to try one of these glp-1's. I have no idea where to start. I don't have a doctor or insurance. How do I get started? And which is less side affects? I want to do the micro dose.
Hi guys,
So I’ve been on wegovy and zepbound before- and have had success with both. I stopped because I got pregnant both times.
I tried to get on it again for weight loss but my insurance doesn’t cover it. So yesterday I went to an urgent care by my house and it turns out they have a weight management program- tirzepatide is the medication given. So the cost to meet w them once a month is $85- and apparently the pharmacy they work with gives the clients coupons to get the medication really cheap.
The Dr said they get the original medicine from the company that makes it and outs it in the pen, and then the pharmacist there cuts it in half and puts it in a syringe. So I’d take one injection then a few days later I’d take the other. The purpose in that is to lessen side effects and get the benefits of the medication completely (since some have experienced the effects of the medication wear off by day 5.) When I asked how much it is a month he said the coupons the pharmacy gives makes the medicine practically free or if very little charge.
I’ve never heard of this, and my husband is very apprehensive about me doing this. I don’t know if that’s common or even normal lol I have PCOS so I’d really like to get my symptoms (most related to my weigh) under control, but idk is that safe?
Is this micro dosing ? How common is that?
Any advice or suggestions are welcome.
I do want to mention that this is a reputable urgent care with wonderful service and providers.
I am a female, 36yo 5 feet and 130lbs. I was 100 pounds even pre baby and I am 2 years post but can loose my baby weight. I am healthy and worko but for some reason can’t get rid of fat. I am not looking to go back to 100lbs but loosing 5/10lbs would be nice. Primarily because I feel the weight. I hope I don’t get judgement here for this. My primary doctor refuses to hear me and says it’s normal if the baby fat stays. Where so you get your… everything from. I am absolutely clueless where to start so any insight would be so appreciated. Tia!
I take .5 mg of triz. I absolutely love it but I’m losing weight too fast and I cannot get my protein requirements in without getting sick. I’m continuing to weight lift and I feel great unless I eat too much… which appears to be not much at all
Ahhh, it’s been sitting in my fridge for a week now, and I’m really hoping to get started soon.
At the moment, I’m waiting for updates on how my embryos are progressing in the IVF process. I’m planning to freeze them, not transfer anytime soon.
If they grow well, then great - I’ll be done with IVF for now. I’ve been quite focused on this for about a year, though the process sort of started around three years ago (did 2 rounds, then took a 2.5 year break). Since then, I’ve taken it pretty easy and haven’t been focused on cutting calories, and put on a few extra pounds, which I kept telling myself that I'll get to it once I'm done!
If they don’t progress as well, then I may need to do another round, which means the vials will have to wait another month or so.
My original plan was to raw dog the calorie deficit like I used to 4 years ago, like eating konjac, cauliflower rice, having all kinds of sugar replacement that honestly made me feel worse. HIIT workouts 5x a week, lots of walking, even hiring expensive PTs.
Then I discovered GLP1 and this sub, ha!
At 5"3, 140lbs, in my late 30s currently, I've never been less than 135lbs since I was 12. Even with aggressive cut (imo), I only got to 135lbs. I struggled with emotional eating all my life, and been overweight since I was a child. Just an hour ago, I woke up from a nap and decided that I'd binge eat instead, as I was feeling so uncomfortable. Guess that led me to writing this post...
For the first time ever, 120lbs and being really lean seems like a possibility and it feels SO GOOD to even dare to think about it. Suddenly, all the shame and sadness that I had suppressed and forgotten from my teenage years came rushing in, and I felt like I met the 18 year old overweight me (I think 160lbs or so) and said... "let's do it this time, I love you, you are worthy, you will be looking so good soon, your turn came."
A part of me, really wants to get started, as a weight loss and potential glow up represents so much for me. This tough IVF process, ending of a relationship, changing of a career (still figuring), there's just so much I'm rebuilding at the moment, all by myself.
(Anyway, I bought a three-month supply because I had planned to leave the U.S. as soon as I finished this IVF cycle, and I didn’t want to deal with trying to access compounded medication overseas.)
Fingers crossed that I can start this soon, very soon!
Anyone know what 503B pharmacies Noom and Ro use to issue “microdose” as advertised to their customers?
Was on Tirz with B12 from a compound pharmacy for 5 months and was PERFECT. Went grey due to cost, got my vial tested etc. 3 days after my first grey dose I had a major panic attack/ anxiety attack and since then have have a subtle uncomfortable ache in my gut / middle ab area.
Starting to second think If I should have went this route and having my anxiety get the best of me. Not sure why 9 days in I still feel not 100%. I wake up slightly nauseous.
Anyone care to give me some relief or straight truths ? I
I’ve been taking compounded semi (currently at .6mg) for about 5 months and it’s been great. I’ve lost 11 pounds so far and have about 10 more to go.
For the past 3 weeks or so it started losing its effect. My options are to increase my current meds or to switch to a compounded tirzepatide.
I keep going back and forth about what to do! On one hand I’ve been tolerating semi pretty well with minimal side effects. Plus it’s cheaper than the tirz. On the other hand tirz is supposed to be more effective.
I also want to point out that I have not been exercising consistently until about a month ago and I plan on continuing to do so moving forward.
I appreciate any feedback!
Hopefully this post is allowed here. I'm to reddit and trying to figure out all of the rules.
I've decided to start back up. I got my email this morning about my order. I'm exciting to get this started again.
Your pharmacy has begun preparing your compounded tirzepatide for shipment. Here's your tracking information — note that tracking details may take up to 24 hours to appear while your package is being dispatched.
After doing a lot of research, I finally ordered my first ever supply of compounded Tirz. I realized that most companies charge way more for micro dosing than they do for regular doses, which in and of itself is unfair, but Maximus was $249 for 10 weeks (2.5 months), which seems ok for a first dip into this.
However, I just went onto their website - bc I need to figure out how to proceed (if indeed I wish to proceed at all), and I figured that first order probably roped me into some sort of subscription which I would need to cancel. It seems like after that first supply for $250, 10 weeks going forward would cost $399, which is way too much!! I literally got one vial of 1ml of compounded Tirz at 10mg/ml. So a total of 10mg - which is what others take in one week!! No way will I pay that much for a super tiny dose.
I was hoping people could point me in the right direction of where I might be able to purchase a larger supply - ideally, a vial that contains a stronger concentration and that I would be able to use at my very small dose of my choosing. It is not fair to charge people more for a smaller amount! I did all this research, and I am STILL totally confused as to how this works!! Will I just need to company hop every time I want to order more meds? Sign up for a new plan every time and cancel after the first delivery?
There has got to be a better / easier way. I'm hoping you can help me out - TIA!!
Researchers at Stanford Medicine have found a naturally occurring peptide — a tiny protein fragment your body already makes — that appears to cut appetite and drive fat loss in animals with none of the nausea, constipation, or muscle loss that come with drugs like Ozempic. The peptide, called BRP, works on a completely different part of the brain than existing weight loss drugs. And it was discovered not by years of traditional lab work, but by an AI tool the team built specifically for this search.
The results were published in Nature in April 2026.
Semaglutide (the active ingredient in Ozempic and Wegovy) works by mimicking a hormone called GLP-1. It's remarkably effective — people lose 15% or more of their body weight on average. But GLP-1 receptors aren't only in the brain. They're also in the stomach, gut, and pancreas. That's why the drug causes nausea, slows digestion, lowers blood sugar, and in some people, leads to muscle loss alongside fat loss. The drug is doing a lot of things at once because its target is everywhere.
BRP takes a narrower path. It appears to act specifically on the hypothalamus — the part of the brain that controls hunger and energy use. In theory, a compound that only speaks to the brain's appetite center could produce the weight loss effect without the digestive fallout. That's the core of what makes this finding interesting.
The body produces thousands of hormones and hormone fragments. Many start out as larger inactive proteins — called prohormones — that get snipped into smaller active pieces by enzymes. The problem is that each prohormone can be cut in dozens of different ways, producing fragments that could be biologically active or completely inert. Telling the difference using conventional lab methods is slow, expensive, and largely guesswork.
The Stanford team built a computer tool they called Peptide Predictor. It scanned all 20,000 human protein-coding genes looking for prohormones that could be cut into peptide hormones — focusing specifically on proteins that are secreted outside cells (a hallmark of hormones) and that have multiple cutting points. That narrowed the field from 20,000 proteins down to 373 prohormones, which the algorithm then processed into 2,683 possible peptide candidates.
From those, the researchers hand-picked 100 to test on lab-grown brain cells — including GLP-1 as a known benchmark. BRP wasn't one of the obvious candidates. It's just 12 amino acids long, which is tiny even by peptide standards. But when tested, it activated appetite-controlling neurons at ten times the strength of the control cells. GLP-1, the basis of the most successful weight loss drug ever made, produced a noticeably weaker response.
After the cell results, the team tested BRP in both lean mice and minipigs. Minipigs were included specifically because their metabolism and eating patterns are closer to humans than mice are — a deliberate attempt to get results that might actually translate.
A single injection of BRP before a meal reduced food intake by up to 50% within an hour. In obese mice given daily injections for two weeks, the animals lost an average of 3 grams of body weight — almost entirely from fat. Untreated mice gained about 3 grams over the same period. The treated animals also showed better responses to glucose and insulin, suggesting metabolic improvements beyond just eating less.
Crucially, the researchers looked specifically for the side effects that plague existing drugs. The animals showed no changes in movement, no increased anxiety, no change in how much water they drank, and no disruption to their digestion. Further analysis confirmed that BRP activates different brain circuits than GLP-1 — it's not just a weaker version of the same thing, it's working through a distinct pathway.
BRP is early-stage research. Animal studies — even in minipigs — are a long way from human clinical trials, and most compounds that look promising in animals don't make it through human testing. The researchers themselves are careful about this: they still need to identify exactly which receptors BRP binds to, understand how it's broken down in the body, and figure out how to make its effects last long enough to be practical as a drug.
That said, the team is moving forward. Katrin Svensson, the study's senior author and an assistant professor of pathology at Stanford, has co-founded a company called Merrifield Therapeutics specifically to develop BRP toward clinical trials. Human trials are described as planned for the near future.
The context matters here. Semaglutide and tirzepatide have been transformative — weight loss results that were previously only seen with surgery, achieved with a weekly injection. But they're not tolerated well by everyone, and the side effect profile keeps a meaningful portion of patients from staying on them long-term. A compound that could deliver comparable appetite suppression without gut involvement would address one of the most significant unmet needs in obesity medicine.
"Nothing we've tested before has compared to semaglutide's ability to decrease appetite and body weight," Svensson said. "We are very eager to learn if it is safe and effective in humans."
BRP stands for BRINP2-Related Peptide — named after the larger protein it's derived from (BRINP2, or BMP/retinoic acid inducible neural specific 2). It is naturally produced in the body, which puts it in a different conceptual category than synthetic drugs. Whether that biological origin translates into a better safety profile in humans remains to be tested. But it's part of why the discovery is generating attention beyond the usual new-drug coverage.
The research involved scientists from Stanford, UC Berkeley, the University of Minnesota, and the University of British Columbia. Funding came from the National Institutes of Health, the American Heart Association, the Carlsberg Foundation, and Stanford's Wu Tsai Human Performance Alliance.
Source: Stanford Medicine, Nature, April 2026. Laetitia Coassolo et al. Svensson and Coassolo are listed as inventors on patents related to BRP for metabolic disorders.
Hi, has anybody purchased any GLP’s from Pink Pony peptides? If so, is it good or bad? I know that they had a letter sent to them from the FDA because they were sending the water that you mix with the powder with and charging for that and you can’t do that (which is weird because you can buy that stuff anywhere so I don’t know why they can’t) I’m guessing it probably comes down to implications of human use. So that’s what that whole thing was about if you research it online, but that’s really the only “bad” thing on them That I can find. But their prices are very affordable and they list their test testing results and everything. So if anybody has any experience, I would greatly appreciate that. Thank you in advance.!
I don't know if it's just a coincidence of perimenopause starting around the same time as I started microdosing but I've been on 1mg since around Sept. Around that same time my periods have gone from very regular to a little wacky. Anyone else? Seems like such a low dose wouldn't do that.
I’ve been on a semaglutide microdose for 20 weeks. I’ve lost 10 pounds but plateaued there at about week 10. Have steadily increased dose as instructed through Noom app, and am now at .6 weekly.
I no longer have any side effects, which is nice. I also have no benefits. I’ve gone back to being hungry literally all the time, craving junk food, and gaining/losing a pound back and forth forever.
Have I reached the end of my microdose journey?
I’ve been ordering from Brello for the past 6 months and it’s been great. I paused my account in February because I had so much extra medication I didn’t need a shipment at the time. Well I’m ready to reorder now and can’t figure out how? I have tried their chat service and emailing but can’t get an answer.
I reactivated my account but it’s saying my next shipment isn’t until June (I think it’s acting as if I did get that shipment in February?) but I need it now.
Anyone been through this? How do I re-order now?