r/BioHackingGuide

Have a friend who is having a lot of issues with Adderall, but cannot cope in life without it. No, not me. He claims to have "circulation" issues with long-term Adderall. Thoughts on Semax and Selank? Any suggestions from your experiences are most welcome.

was scrolling through PubMed on a Friday night like the nerd I am and found a post-hoc analysis of SURMOUNT-1 looking at liver fat. They did MRI-PDFF on a bunch of participants with NAFLD at baseline. Fancy MRI that actually measures fat percentage in your liver. The numbers are wild honestly. People on tirzepatide 10mg or 15mg had relative liver fat reductions of around 70%. Over 90% of people on the 15mg dose got down to normal liver fat levels (<5%). Ninety percent.

My hepatologist has been watching my liver enzymes for years. ALT used to be 85. Now it's 22. She kept saying "keep doing what you're doing" but never explained that my liver might actually be healing, not just getting less inflamed. I asked her about this at my last appointment. She said yeah, the imaging studies are showing actual regression of fibrosis in some patients. Not just less fat, but less scarring. I've been on Mounjaro for a year and apparently my liver is reversing decades of damage Wild.

I feel I speak for quite a few people when I say many of us wish they started some things sooner, or that they were informed about some knowledge, etc

As someone who one day wants to be a parent down the line, and wants to give my future kid's lives the best I possibly can, I see myself probably trying to optimize their well being

Obviously covering all the basic fundamentals of eating right, exercise, sleep, hydration, etc, but more than that

I hope I'm not offending or scaring ppl getting y'all to think "omg they're gonna get body dysmorphia" "don't project" "you're crazy don't have kids", I definitely see myself not going out of line with aggressive things like lets say fasting or peptides. I think stuff that's within reason that could benefit them and that discretely improves their lives. Nothing at the moment is sprouting to mind, but idk I guess something like maxing Vo2, or some soft anti-aging routines or something, I don't really know but I think you get the picture

See the iffy part is accidentally making them unnecessarily self conscious about things a kid or adolescent just shouldn't worry about, but again if I feel if its within good parameters, in reason, and not extreme, and prioritizing/emphasizing the right habits and lessons, it could actually mitigate any later down the line problems that youth tend to struggle with (low self esteem, body image, poor mental health, lack of sleep, etc)

Any parents here done this? Or anyone thought of themselves doing this as well? Any thoughts?

If you could go back to day one what would you tell yourself?

Not a protocol. Not a compound list. Just the one thing nobody told you that you had to figure out the hard way.

Dosing, sourcing, reconstitution, expectations, timing whatever it is.

What is it?

Could be something you keep seeing come up but cannot find solid info on. Something you are thinking about running but still have questions on or just something you read about and want to understand better.

Drop it below. Either I will cover it in an upcoming post or someone in here who has actually ran it can give you a real answer.​​​​​​​​​​​​​​​​

Been wanting to try this stack adamax is basically semax but it last longer like 6 to 8 hours per dose instead of an hour p21 hits BDNF from a different angle so stacking them kinda made sense to me.

What I ran

• Adamax 300mcg intranasal in the morning
• P21 300mcg SubQ same time
• 4 weeks on, 2 weeks off

Not gonna lie first week I took it later in the day than I should have and could not sleep after that I kept it strictly morning

What I noticed week by week

Week one felt just kinda less scattered and easier to lock in on stuff

Week two started feeling more not like a stimulant just more mental stamina throughout the day less friction.

Week three and four were pretty consistent dose in the morning and it carried through most of the day the thing I kept noticing most was recall like I was holding onto details way better than what I normally do

My thoughts

It is not gonna hit you like a stimulant it is more like things just flow easier and you kinda realize it at the end of the day when you look back at what you got done.

Anyone here try these at all?

On one hand the whole point of communities like this is that people are doing their own research running their own bloodwork tracking their own results a lot of us here probably know more about BPC-157 or Tesamorelin than their GP does asking your average doctor about peptide protocols is like asking someone who has never touched a car to diagnose an engine problem.

On the other hand contaminated products are real dosing errors happen and in all reality there are compounds that can cause problems if something goes wrong without anyone monitoring you. So what the truth?

Is a doctor necessary or is it more about having the right information, running bloodwork yourself, and knowing what to watch for? Or is the whole doctor conversation just and extra step people added for no reason?

My dog has been dealing with some joint stiffness and her coat has seen better days started wondering if BPC-157 or GHK-Cu could do anything for her the same way they work for people.

BPC-157 for the joint and gut side. GHK-Cu for skin and coat. The mechanisms are not that different in animals I read a lot of the original BPC research was done on rodents so I'm guessing its ok I'm not too sure

Has anyone tried either of these with their dog or any other pet did anything change?

Recently I saw instructions of how to create a peptide facial serum , the suggestion is to mix sterile water instead of BAC for reconstitution of Peptide. I’m curious as to why this would be recommended? Any thoughts ?

Is chasing higher IGF-1 numbers like maxing it out is the goal good or a bad thing or does it start working against you at some point?

When thinking GHK-Cuwe normally think about skin, collagen, wound healing but lets talk about something I honestly haven't read much about before

So Zinc and copper share the same absorption pathway in your gut they compete for the same spot run high dose zinc and copper gets blocked run high dose GHK-Cu for a while and the opposite starts happening copper builds and zinc starts losing ground.

Copper runs cytochrome C oxidase which is one of the most important enzymes in your mitochondria too little and your cells cannot make energy right the depletion is slow too. energy feels off, bloodwork looks a little weird, and by the time you notice it your way too tired already

So if you are running GHK-Cu at higher doses for a while keep your think in mind it might not be a issue forsure but its a problem that can happen.

Same thing goes the other way. Running 50 or 60mg of zinc and your energy is in the gutter for no obvious reason copper depletion is probably why anything over 30mg of zinc pair it with 1 to 2mg of copper and take them at different times.

Also worth knowing some people retain copper genetically or already get enough from diet so a hair mineral analysis or basic serum panel gives you an baseline before you start loading either one witch is why I think bloodwork is always required.