So the SURMOUNT-1 liver data came out last month...
was scrolling through PubMed on a Friday night like the nerd I am and found a post-hoc analysis of SURMOUNT-1 looking at liver fat. They did MRI-PDFF on a bunch of participants with NAFLD at baseline. Fancy MRI that actually measures fat percentage in your liver. The numbers are wild honestly. People on tirzepatide 10mg or 15mg had relative liver fat reductions of around 70%. Over 90% of people on the 15mg dose got down to normal liver fat levels (<5%). Ninety percent.
My hepatologist has been watching my liver enzymes for years. ALT used to be 85. Now it's 22. She kept saying "keep doing what you're doing" but never explained that my liver might actually be healing, not just getting less inflamed. I asked her about this at my last appointment. She said yeah, the imaging studies are showing actual regression of fibrosis in some patients. Not just less fat, but less scarring. I've been on Mounjaro for a year and apparently my liver is reversing decades of damage Wild.