u/EagleEyezzzzz

A new meta-analysis in Fertility and Sterility pooled data from 12 trials of GLP-1s in women with PCOS.

- Findings (significant improvements):

- Menstrual regularity: 2.3x more likely to have regular cycles

- Testosterone levels: decreased by 15%

- Hirsutism (unwanted hair growth): modest improvement

- Insulin resistance: HOMA-IR improved by 30%

Importantly: Many of these benefits were seen in trials that did NOT have significant weight loss. Direct effects on ovarian function, not just weight.

I don't have PCOS, but my sister does. She's been trying to get a GLP-1 for fertility reasons. Her insurance denied it because "not FDA approved." This meta-analysis is ammo for her appeal.

Has anyone else noticed this? I’ve been sober for over a year, and while I did a lot of hard work and utilized a lot of tools, my use of Semaglutide for weight loss was 100% the thing that got me over the finish line to sobriety.

I love the r/stopdrinking sub and think it’s fantastic for support. I’ve also really appreciated seeing all the anecdotal stories about GLP-1s helping so many people. Until recently!!! Apparently it’s against the rules now to mention it in any way. I discovered this and recently made a comment just saying “Can’t discuss it here, but check out the dryzempic sub, this approach has been life changing for me” and even that got deleted!! It’s wild to me that we KNOW these drugs help with eliminating addiction cravings more than any other drug available to people, and that use is being researched and published in the scientific community, and yet you can’t even mention it “from the ‘I’ perspective” or whatever.

Just sad a little that all the people struggling there don’t have the chance to hear any first person accounts of something that has helped me so tremendously.

Happy weekend all! IWNDWYT!