r/PCOSonGLP

Polycystic ovary syndrome (PCOS), a condition affecting more than 170 million people worldwide, has been officially renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS) following a landmark global consensus study published today in The Lancet.

The new name recognizes that the condition is not a primarily gynecological disorder, but is instead a complex, multisystem condition involving endocrine, metabolic, reproductive, dermatological and psychological health. Additionally, the recategorizing will include updates to clinical guidelines, medical education and international disease classification systems, ensuring the new terminology is adopted consistently worldwide.

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHH!!!!!!!!!!!!!!!!!!!!!!!!!

So I have seen so many people on social media whom have used GLP-1 medications and have lost weight. Some it takes months others years.

I am now seeing where they are sayin some doctors have different dosages or ingredients in the medications that help with the weight loss time period. I DONT KNOW what to do anymore!!

I think I have tried everything and still struggling to lose the STUBBORN belly fat. I have used Ozempic - they said its for people who are diabetic - didnt work for me. Currently on Zepbound - definitely suppress my appetite fxxxxk.

I know I'm not alone: who are you (chose from the listing and comment below):

• Currently using Ozempic / Wegovy / Semaglutide
• Currently using Mounjaro / Zepbound / Tirzepatide
• Currently using a compounded GLP-1
• Considering it but haven't started
• Recently stopped (within the last 6 months)
• Used it in the past for 6+ months
• Not using and not considering

Hello all. Before I ask my question, I wanna give some background about myself.

I was diagnosed with PCOS at age 19 and am 27 now. My PCOS has always been quite mild. My periods were next to non-existent, no hirsutism, no extreme weight gain, no insulin resistance, no blood work abnormalities, etc. The "worst" of it was severe cystic acne that I was able to quickly get rid of with Spironolactone and birth control pills. Until recently, my PCOS was little more than just a mild inconvenience.

My most recent blood work shows I now have insulin resistance (bordering pre-diabetes) and high body inflammation. I've also gained roughly 25kg in the past 1.5-2 years. That might not seem crazy, but my diet and activity levels are no different than they were when I was "fine". For whatever reason, my PCOS has caused a deterioration in my health, and I'm really feeling unwell these days. Just a general malaise and exhaustion that won't go away.

After my current doctor has let this go on and on (a whole other ANNOYING story), I've finally decided I need to try a GLP-1. The GLP-1 I'm interested in is Mounjaro. My question is: have any of you experienced a decrease in inflammation while taking Mounjaro (or any GLP-1)? How has it made you feel overall?

I want to feel better. I feel so sick these days and seeing the scale creep up day by day is depressing and demoralizing. I've tried it all. Inositol, other supplements, diets, exercise, calorie counting, macro counting, mindfulness...EVERYTHING. Nothing works. I'm feeling sicker with each passing week. A GLP-1 is my only hope.

Thank you to anyone who reads this and has any advice to offer.

What do you all think of this new name?

25F
I started Zep bound in March 2025. My starting weight was 214 and my current weight is 156. It has changed my life in every which way. My periods are 100% back to normal, my acne is gone, I have energy… it’s just amazing.

Anyway my doctor keeps pushing me taking metformin while on Zep bound saying “you will gain all of this weight back if you’re not on metformin when you go off of Zep” and she said “Ok you’ll have to take Zep for the rest of your life if you don’t want to take metformin”

My fasting blood glucose is 89. This has stayed the same during my weightloss journey. It’s within the normal range. I’ve tried metformin years ago and it was awful. Zepbound is 10x better and 100% worth the out of pocket cost, to me.

Why is she saying this to me if my insulin and blood glucose levels are normal and have been normal before weight loss? Has anyone else heard this before?

TIA

One of my most prominent side effects of Wegovy (been on it for a little over a year) is tachycardia, especially when going from sitting > standing. It wasn't as bad in the beginning but progressed. And then, because my bp is so good now, I often feel faint/dizzy and once or twice have actually had to immediately collapse to the floor.

Has anyone else experienced this and found ways to mitigate it, or switch to a different option that didn't cause this specifically? While a normal/documented side effect, it makes me nervous.

I was at a women’s health event today tied to US women’s health week. This name change was actually a major topic of discussion which is positive. But people including physicians were still saying PCOS in conversation.

I’ve long said I have an “endocrine disorder” when I don’t want to explain what PCOS is, especially to men. I feel even more justified in saying I have an endocrine disorder now.

I’m the founding mod for this sub. I can’t change the name and worry about people finding us.

I’m still thrown off by “ovarian” in the name as someone with PCOS who has high AMH and high follicle count (I knew they weren’t cysts), but doesn’t have high testosterone but rather high DHEA-S (adrenal driven rather than ovarian).

I also don’t think this name change matters too much. I actually think GLP-1 medications are doing more to educate people about PCOS / PMOS than the name change. Because we’ve known thru lived experience that GLP-1s are treating PCOS … so we knew already about the endocrine and metabolic components. There are GLP and GIP receptors in the brain.

1 in 8 women have PCOS. In the US, 1 in 5 of those women have already tried a GLP-1. The new era of PCOS / PMOS treatment had already begun prior to this name change.

Hi All,

Anyone used metformin and GlP-1 at the same time? I am interested since I know they work on different pathways towards the same result. Thanks.

unfortunately, insurance companies across massachusetts are going to stop covering GLP-1s for anything other than diabetes, and as of this month my insurance is not covering it at all. so that leaves me with having no choice other than to pay out of pocket. i am fresh out of grad school, working as a very underpaid para, and just cannot shoulder the cost.

i am curious if anyone has switched from a GLP-1 to metformin? metformin is covered and is also designed to help with managing insulin - which is my main issue. i am worried about gaining weight back (lost about 40lbs on zepbound) and not having as affective "hunger supression" as on the semigultide. i can deal with gaining a little back, but i cannot go back to feeling constant hunger pains again...

of course i am going to talk to my endo about this, but i want to hear from other folks with PCOS and get some ideas on what the effects might be.

open to advice! thanks!

Hi, I recently had an appointment with an Endocrinologist and he suggested semaglutide or tirzepatide for my PCOS. I haven’t started them yet, my blood work came in.. I was actually asking him about Berberine but he said it doesn’t work.

My condition: Diagnosed with PCOS almost 15 years back, overweight, I work out 4 times in a week and yet no improvement in weight.. But I get my periods regularly. I have acanthosis nigricans in my neck and inner thigh area. My blood work cam in as prediabetic and very low vit D.

So before starting on GLP1, I wanted to ask if anyone’s tried it in India, how much did it cost, what was the level of improvement noticed.

i finally caved and purchased zepbound through a telehealth company. im 24, and cant even look in a mirror. i am successful for my age, and i feel like i cannot celebrate my accomplishments because of my weight. im 5’5, ~200lbs. i dont feel feminine.

i don’t want to be on zepbound forever. i want it to be short-term, but i don’t feel like that’s typical for a lot of people.

for people who have stopped taking zepbound, what has your experience been? have your symptoms come back pretty quickly?

Started Wegovy coming up to 4 weeks ago, 4th dose is due Monday.

Within a week or so I had a period which was great as they are pretty irregular. Really normal period too, not ridiculously heavy, more tired than usual and some bloating but otherwise happy days. It finished a few days ago.

However, not one pound has shifted. Zero. Am I expecting too much too soon? Or should I have lost some weight by now if Wegovy is going to be effective for me?

Hi everyone, I’m here with my update on my experience and I’m kinda freaking out and would really love to hear if anyone has had something similar.

I just did my first 2.5 mg shot of Zepbound (I’ve done Wegovy before but it’s been like 8 months). I’m taking it for PCOS.

Everything was fine at first, but about 2 hours in I started feeling off, then it turned into really intense, constant nausea. Not even in waves just nonstop. It lasted for like 9 hours straight. I barely slept, couldn’t really drink water, and even small bites of food made me feel worse.

I took Zofran (4mg, twice), tried Tums, and eventually Gas-X. Nothing really touched it for a long time. I also had a lot of trapped gas and burping (honestly the only thing that gave a tiny bit of relief).

At one point I genuinely thought I might be stuck feeling like that or that something was wrong because it just would not let up.

I finally got about 2 hours of sleep and I feel a little better now, but still off.

Has anyone else had it hit this hard on the first dose?
Did it get better for you after the first day / first week?
I’m honestly scared to take the next shot if it’s going to be like that again.

Any advice or similar experiences would really help right now 🥺

24y/o, I’ve been on compounded semaglutide since December (down 30 lbs) and I normally don’t really have a period naturally (at most 2-3x a year) this is my first time naturally getting a period since the shots but I did have a few weeks of spotting before.
TMI warning but Every time I think my period is over, I get a random blood clot that comes out with no other bleeding for the whole day. It’s been happening once a day since my actual period ended (it’s been about a week) This has never happened to me so I’m wondering if it’s because of the medication? Or because I went without a cycle for so long? Let me know your personal experiences 🥺

A new meta-analysis in Fertility and Sterility pooled data from 12 trials of GLP-1s in women with PCOS.

- Findings (significant improvements):

- Menstrual regularity: 2.3x more likely to have regular cycles

- Testosterone levels: decreased by 15%

- Hirsutism (unwanted hair growth): modest improvement

- Insulin resistance: HOMA-IR improved by 30%

Importantly: Many of these benefits were seen in trials that did NOT have significant weight loss. Direct effects on ovarian function, not just weight.

I don't have PCOS, but my sister does. She's been trying to get a GLP-1 for fertility reasons. Her insurance denied it because "not FDA approved." This meta-analysis is ammo for her appeal.

I’m on zepbound 5mg with Ro and pay it cash, membership and medication. Unfortunately I dont have insurance and I will be going out of the country to visit sick family. Is there a way to get a 3 month script on Ro or is there another more affordable option that will write me the 3 month script and ship it to my house?

Ro is crazy expensive even with their new multi-month membership! Urgh, I really wish the health care was more affordable.

I did see some other threads about this but they were all over a year old.