u/ConsiderationRich378

TW: prior pregnancy & pregnancy loss

Background: I am anovulatory. At the beginning of my TTC journey my OB stair stepped me to 5mg of letrozole to induce ovulation. I would successfully ovulate usually CD20 WITH NO PAIN. On this medication I conceived on my 2nd cycle of the medication, which sadly ended up in MMC (I weighed 187lbs at the time this ended). Once again, I wasn’t ovulating and started the medication and on the 2nd cycle conceived again, which also sadly ended in MMC (lost weight and weighed around 172lbs). I then started Metformin and spontaneously conceived my third pregnancy which also ended in MC (lost more weight and weighed 165lbs). Never have I experienced ovulation pain on or off letrozole. Now since my third MC (current weight ~156lbs), I have done 3 cycles of letrozole. 1st cycle was normal CD20 ovulation with no pain. 2nd cycle was unusual as I peaked very early on CD15/16 and experienced breast tenderness/bloating. 3rd cycle (now) I have experienced spotting on CD10/11 and my LH peaked early again on CD16/17 with extremely painful ovulation cramps waking me up in the early morning CD18 and had to take a bath to find relief. I had constipation, trapped gas, bloating, cramping, and the feeling of a heavy uterus. The pain really only lasted the day but I have had tenderness and side pains here and there— I was able to resume running two days after ovulation.

Context: I mention my weight here as I’m wondering if my weightloss has played a factor in how my body is responding to the medication along with the metformin combination. My last three letrozole cycles have been unmonitored as my doctor says he doesn’t want to waste my time and money and I have ovulated successfully in the past on this medication.

My Questions: has anybody had this experience? I called my doctor and he says “oh this is normal blah blah, let’s just see if you get pregnant and if not see ya at your annual in June”. Did my weightloss make my body start to over respond? I wonder if I just produced more eggs or something this cycle to make it so painful? Do I have a cyst (what does that feel like)? Have I suddenly developed endo or adeno? I’m just at a loss and a bit surprised I haven’t conceived yet so I’m feeling at a loss.

If you’re still reading thanks for listening, and please post your experiences on the medication along with success stories❤️

I experienced my third miscarriage back in January 2026. For background I had one miscarriage in May 2025, another in October 2025. I have anovulatory cycles and on letrozole have conceived everytime I tried. Starting after my first miscarriage I started losing weight intentionally through calorie deficit and am currently 30lbs lights than when I conceived my first pregnancy last year. Starting after my second miscarriage I started metformin and got pregnant spontaneously with my third baby without knowing! I did have EWCM that cycle but didn’t think too much of it. He was perfect until I lost him to SCH at 10w. I had an ultrasound and confirmed all POC were gone and had an HSG done and confirmed everything was normal. I went back on letrozole and had one normal cycle where I added progesterone at 3DPO and I didn’t conceive. I took letrozole again the next cycle but had a lot of discomfort around ovulation (sore breasts, bloating, moody) with my peak coming three days earlier than usual and ultimately didn’t take progesterone afterward in hopes of conceiving (I didn’t). Now I’m on my third cycle of letrozole (spotted CD11&12 and my peak came two days earlier from normal and I had the most pain I’ve ever had associated with ovulation (bloating cramping, gas, constipation, frequent urination). Im stunned and don’t know what’s going on— I already feel like I’m not going to concieve this cycle and I’m not sure why my ovulation has moved or why it has become so painful— it’s never been painful before and I usually conceive everytime I try. I’m at a loss of what is going on… is the metformin with weightloss combination moving up my ovulation and making it painful? Is it long distance running that’s hard on my body? do I have endometriosis all of the sudden? Are my hormones thrown off from using progesterone back in march? I’m at a loss and so tired of this journey I just want to sob endlessly.