Has anyone used a GLP1 to lose weight, in an effort to manage PCOS and get pregnant? Looking for insight, advice and overall guidance. Months of failed fertility treatment and I’m at the end of my rope.. looking to try something else
Hi everyone, please delete if not allowed. My husband and I have been trying for a kiddo for 4 years now. We have recently learned that I need to have an ovarian wedge surgery. I will have to pay $19k usd, I made a gofundme to try to raise funds. I have posted it on all of my socials. Does any one else have any ideas? Thank you so much!
I don't know how to stay positive - or sane - when it feels like I'm trying so hard, but nothing works. For context, I almost never menstruate on my own so a big part of my TTC process was trying to just have a period for a year before I went to a fertility clinic to get down to business.
I used OPK's - never gotten a positive.
I track my temperature - never any idication of ovulation
I take what feels like an entire breakfast work of supplements and pills every morning. No difference.
I'v been taking ovasitol for almost 2 years now. No difference.
I've been on Metformin for almost a year now, and increased my dose from 2000 to 4000mg about 4 months ago. No difference.
Just did my first monitored cycle, starting on 5mg letrozole. Follicles weren't big enough and had poor selection. Took another round of 5mg letrozole in the same cycle. Still not big enough, still poor selection. Took another round of letrozole, this time 7.5mg. Biggest follicle was only 12mm. Cycle canceled. Goodbye $1200 with nothing to show for it.
I'm so discouraged. I'm so mad at my body. It feels like this is never going to happen unless we do IVF - and I really don't want to do IVF. But even if we did, it feels like my body is so resistant, that wouldn't work either. If SOMETHING would just work the way it is supposed to, maybe I could have some hope, but it feels like failure after failure. And I know it's not my fault, but honestly, I wish it was. I wish there was something someone could point to and say, "This is why you're not getting pregnant. Stop doing that and it will happen." It would be easier that way. Instead, I punish myself by simultaneously believing that nothing I do is going to help, but still beating myself up when I don't do things perfectly. And the world punishes me with pregnant friends, baby showers, and negative test after negative test.
Why can't I just have a body that does what it is supposed to?
I'm in my early 30s, officially diagnosed with PCOS about 4 years ago. I was on the pill for a while but when I stopped taking it, my cycle has continued ro be regular for the past 2 years.
We have officially started TTC this year and have been on 3 letrozole cycles. I was more optimistic with each passing cycle because I have been ovulating on letrozole, my endometrium has trilaminar lining, and the most recent cycle had 2 eggs that reached maturity.
My hormone panel is good, my HSG showed patent tubes, and my husband's semen analysis were also good. My blood chem also shows fairly normal results. I seem to have insulin resistance, though, since my OGTT-2nd hr is slightly elevated and I have been taking Metformin for about 2 months now. On paper, everything looks good. I've also started exercising more and have lost about 5% of my initial body weight. But we were not successful on this 3rd cycle. My OB-REI said that we would do another letrozole cycle and the way she said it made me think that she would recommend IUI if the next cycle is still unsuccessful.
I'm feeling the weight of this cycle because I'm not sure if I'm ready for IUI or any other procedure that would escalate the current protocol.
I would like to seek success stories after a few cycles of letrozole or any stories from everyone ttc as well. I am more comfortable sharing this online in a community that may be going through or may have gone through similar concerns.
Thank you!
Has anyone here with a BMI of 50 or more had a succesful pregnancy?
My doctirs say that if I lost even 10% of my body weight, that it would make a bug difference. I am struggling because I have an extensive history of eating disorders and my insurance keeps denying coverage of GLP-1 (I am on my third or fourth appeal).
I don't have diabetes, high blood pressure, or high cholestrol and I am in my late twenties. I have struggled with my weight and insulin resistance since I was in grade school.
PCOS and weight gain feel like a never ending cycle that feeds into itself. Any advice is appreciated
My partner and I have been trying to conceive since the end of 2024. We finally started seeing a fertility specialist earlier this year, which is when I received my PCOS diagnosis. My main symptom is irregular periods (typically 29-45 days).
We just tried our first fertility treatment (Letrozole, trigger shot, and TI), but that wasn’t successful.
To cover all our bases, we also did a semen analysis for my partner. Mobility and quantity came back great, but I think that information might have done a disservice to us because he doesn’t seem to believe he needs to do anything to further promote his fertility. I’ve explained to him multiple times and sent him many articles about how alcohol impacts sperm quality, yet he will not change his behavior. I understand that he likely needs professional help to stop, but given we already have my PCOS working against us, it really hurts that he hasn’t committed. I do not want to pay for or put my body through further treatment until he can commit.
Has anyone else experienced something similar? Any suggestions for getting my partner to come around?
Just curious how long it took you from your decision to move to IVF to actually starting. I did an IUI this month and would like to opt for ivf if unsuccessful. I was told between the consult, the ordering of the meds, and the insurance coordination this could take up to a month (so not next cycle next week). Does this sound right?
I was told I could do another IUI during that month so it’s not a “wasted” month. Which sounds like a better option if we indeed have to wait.
Curious to hear others experiences/timelines
TW: Living child
I am currently on day 21 of a medicated TI cycle. My period comes exactly on day 28 with the 2.5mg Letrozole and trigger shot so I feel like starting to cramp now is way to early but I cramped early last cycle and my period came.
It feels just like my period and I am just feeling so devastated. Particularly bc I have been advised we will be recommended IUI next cycle and it doesn't seem like there is a high probability it will help.
We are a year and a half into ttc a second child (did TI monitored cycles for 1st).
Just seeking advice or to commiserate with others.
What do you wish you would’ve known at the start of your TTC journey?
I’m 29. I was diagnosed with PCOS in October due to irregular periods (anywhere from 28-70 days) and slightly elevated testosterone. Since my diagnosis, I’ve lost 40 lbs, have started taking myo inositol - d chiro (now my cycles are ~32 days), and am planning to add CoQ10 to the mix. I have an Oura ring that has been wonderful helping predict my cycle.
My husband is very healthy, works out daily, stays on top of supplements for overall health, and eats very balanced meals.
We are excited but nervous to start this journey in a couple months. Give me all your advice!
I have to get up at about 5:30 am for my job and for the past two days I'm waking up feeling achy, dizzy, and nauseous. It's not until I sit down that I feel any sort of relief so I'm having to take breaks in between stuff so I don't pass out or throw up. I thought it was just a fluke because by noon yesterday it went away and I felt completely fine. But now I'm experiencing it again this morning. Has anyone else experienced this and what could be causing it?
Hi everyone,
I am thinking about looking into private fertility clinics for ovulation induction. If you have gone done this route, what clinic did you go to?
I am East Midlands
I just had my HSG test done. A male doctor did it and he was rough and I’m good with pain tolerance but this was so painful. It lasted not even 20 seconds then he was gone. It showed that my left tube is open and clear but they are unsure of the right one (looks blocked) so they’re sending it to my doctor to review.
I’m confused because last November (5 months ago) I had a saline sono done and it was less painful (female doctor did it) and I didn’t clench or tense up and both tubes were open per the doctor.
I sat in my car crying for an hour because I’ve been trying to get pregnant so hearing that my right tube is potentially blocked made me just lose it. I’m currently on my 4th round of letrozole and I feel so hopeless. How does a tube become blocked in just 5 months?
I don't know if others feel the same. I don't usually have a sweet tooth but 6 months now of a low GI diet is really starting to get to me. I enjoy food and it feels like I can't go and have nice meals or have the occasional treat without feeling guilty. I do have dark chocolate sometimes but that's about it.
We're booking a holiday soon and I almost want to be like sod this and eat all the nice things but I know I would regret that. I struggle to know how much it makes a difference and I'm on myo inositol and Metformin and I've not noticed any difference from any of this yet but who knows maybe it's helping and I don't want to risk impacting anything.
What do others do? Are there any times in a medicated cycle when it's more ok to have a treat?
I’m heartbroken. I wish I never let myself get too excited that my IUI was going to work.
What do I do guys, is that common? Should I be hopefully and try a 2/3 time??? ( for reference my follicle was 26mm literally about to pop on CD 18 when I went in for my second follicle scan, doctor triggered me and did IUI then and there).
I’m just sad and am already down a mini rabbit hole of looking at IVF.
Hey everyone.
33F trying to get pregnant since Octobe. Yes I know that it is not a long time but I had no help from my doctor and went some crazy longs cycles… I don‘t ovulate and it is super frustrating. I thought I ovulated (tests, symptoms,…) but nope. I got the diagnosis (that I didn‘t ovulate this cycle) last week and I am crushed. A good friend is pregnant since some months and she complains about her pregnany and that she knows the feeling, that it takes so long to get pregnant. She is healthy and it took her a few months… I don‘t even get the chance to get pregnant 😭
Sorry I am super lonely and frustrated with my diagnosis…
This week I have another appointment and we will start a therapy so that they forced my body to ovulate.
Hopefully I can get pregnant soon, I never felt like this in my life :( Something out of control that I really wish for…
Asked my partner to bring me my phone after we… ya know… so I could log it in my app. They put on their best pirate voice and said: “Ah yes, yer captain’s log! Yarrr!”
It’s silly and unimportant, but after 2 years of trying, being able to laugh at the absurdity of tracking every time we have sex makes things a lot easier. Cheers to good partners!
After having initial consultation with one of the clinics, they recommended to do IVF with freezing embryo and do an embryo transfer rather than a fresh transfer due to me having PCOS and having a high risk of OHSS.
Has anyone had IVF with FET? Was the risk really high? How did your body respond? Is it really the best option?
I’m so confused because the spoke to many clinics and they just recommended me IVF+ICSI but this is the first a different approach was recommended
If anyone has gone through or is going through a similar situation please do guide me some light. I’m really exhausted :(
Hi! So i have PCOS with insulin resistance but this diagnosis has been on the fence depending on which dr I talk to. I have a lot of cysts that come and go, only abnormal lab is DHEA was high. Fertility dr just put me on 1500 mg of metformin about a month and a half go. I had 3 losses in 2025. Just curious if metformin will actually help me if my cycles are regular and I ovulate on my own?
Edit to add: my BMI is 25.8. 29 yo
33 with lean PCOS (diagnosed in my teens), been TTC for over a year but struggled with very irregular cycles (35-70 days ish), obviously making it difficult to catch ovulation and TI.
Finally took my first 2.5mg Letrozole pill tonight and am ~hopeful~ to have a real shot in the coming months! My protocol also includes monitoring and eventually a trigger shot.
Wondering, for those of you who ovulated with their first round of Letrozole, what CD did you ovulate on? Looking for input on successful ovulation, rather than conception. Thank you!
After 20 months of TTC, we finally started on medicated cycles. I ovulated perfectly on our first medicated cycle with letrozole 2.5mg. We didn’t conceive but I had SUCHHH high hopes for our next cycle. It’s cycle day 23 and still no ovulation ☹️ I had two 12mm follicles day 17 during a follicle check that, if I’m understanding correctly, should have matured by now. It didn’t even occur to me that 2.5mg could work great one cycle and not the next, ughhhhh. PCOS SUCKS.