Just a thought I had…
In the episode “this little piggy”, there’s a cutaway of Meg’s birth, showing Peter cutting…something else instead of her umbilical cord, to which the doctor responds “that wasn’t the cord, and now you have a girl”
I think this heavily implies that Meg is biologically male but became a girl after Peter’s stupidity. Even the family guy wiki points this out. Does that clip imply Meg is transgender? Cuz that would be a pretty neat thing to think about