r/whatworkedforme

Has anyone used GLP-1 peptides for infertility and/or prior to pursuing IUI/IVF? I've seen many anecdotes of accidental pregnancies while on these medications. I know they're not recommended if you're actively TTC.

I'm 37, 2 years of TTC with no success. I've never had a positive pregnancy test. I have regular 27 day cycles, 11-12 day luteal phase. I do have insulin resistance and I've been working to improve it over the last year and a half. I've lost 15lbs, lost inches in my waist and gained muscle, and dropped my A1C from 5.7 to 5.3. But I am still overweight. I've been on a lower carb diet but the weight loss has slowed down.
Other stats: AMH dropped from 0.9 to 0.6 in the last 6 months. FSH: 9.22 LH: 4.69 AFC: 29 Prolactin: 23.4 (slightly high). Ovulation tracked and regularly confirmed with BBT. Thyroid normal. No endo symptoms.

I've seen two different REs who've suggested IUI and IVF but due to "unexplained" infertility and age, I want to give myself the best chance before pursuing these difficult and expensive options, or hopefully be able to conceive without them. I'm debating pursuing a couple months of GLP-1 treatment (Tirzepatide) to drop more weight quicker and improve my insulin resistance, and improve my chances. We won't be scheduled for IUI/IVF for at least a few months no matter what.

What I've tried:
- 2 hysteroscopies (no polyps or fibroids)
- an HSG and an SIS (tubes clear, no blockages).
- semen analysis was "very good, above average".
- exercise (weightlifting and cardio training minimum 2 days a week, usually 3)
- acupuncture and traditional Chinese medicine
- keto diet (difficult to sustain, didn't last long)
- lower carb, higher protein, higher fiber diet (currently)
- metformin (currently)
- supplements: Ubiquinol, Myo + D Chiro Inositol, Fish oil, NAC,
- going on vacation + "just relax"

Please give advice to a pretty sad girl,

I’ve just failed my 4th medicated cycle, I moved from clomid, to Letrozole (which I did not respond well too) and then Gonal F injections. This month doing gonal F and trigger shot made me so hopeful, one great follicle and a possible second one 39 progesterone result day 21 of this cycle, every symptom under the sun and boom not pregnant.

I’ve had a HCG done 8 weeks ago, all my bloods are great including my thyroid which is actually fantastic, I’m also only 25.

My partners semen analysis was also incredible.

My fertility specialist said it’s up to me whether I do IUI this cycle and I’m unsure!

I’ve always noticed little CM during ovulation so maybe the iui would help if I do have thicker cm? Did anyone else do one with no partner male factors in the way?

I’m honestly feeling hopeless and exhausted, I know it’s going to be only the 5th medicated cycle month but I just never thought it would take this long, I had so much hope when I met the fertility specialist back in Jan

My known issues before I saw the specialist was the incredibly low progesterone and 8 day luteal phase ALWAYS.

I just feel like giving up, was IUI the final piece of the puzzle for anyone?

It’s been 2.5 years that we’ve been trying to grow our family. I (35F) got all my results back normal, my scans all normal. Hubby (38M) has low count (16millions) but over 50% motility. Doctors said they have seen couples conceive with lower sperm count.
My morale has been affected as I don’t know why this isn’t happening for us. Hubby tried Clomid for 3 months noticed an increase in volume but no baby. Also, I’ve never been pregnant before. Could this be a mental/ psychological blockage ? I do feel scared of giving birth, but I do want to be a mum so badly. I’ve waited to meet the right man, to own a home and to have financial security before deciding to have a family.
I feel stress at work but who doesn’t. Could it be the stress preventing me getting pregnant?
Please tell me what worked for you and any recommendations are appreciated.

I just had my HSG this morning. I would say it’s was mildly to moderately plainly. I didn’t have a horror stories like some others I’ve heard.

My question is, I’m ovulating tonight, and they’ve told me to abstain from sex to avoid infection. The thing is I’m taking anti biotics, and I’m ovulating like now so I don’t want miss a whole month.

Would you try and risk the chance of infection (even though I’m taking antibiotics), or would you just waste the month?

Hi,
I’m 31F. We’ve been trying last 16 months. Both me and my husband tested and got everything normal.

- husband’s sperm is normal
- hsg is normal
- hormones normal
- amh is good
- progestrone 16

We did ultrasound last 6 cycles and I’m ovulating regularly. No pcos. I have regular periods 26-28 days last 6 months.

The problem is I had eating disorders for 2 years. I’m underweight, 168 cm 50.5 kg. I was eating less to not gain. When I ate a lot, I was forcing myself to vomit. I was craving sugar and carbs all the time. Last 1-2 months, I’ve been better. I stopped doing all these and started working with a nutrionist and gained weight(I was 49 kg). Eating lots of protein, less carb, no sugar and no gluten. 3 days in a meal and 2 times healthy snacks. Even though I had eating disorder, I never lost my period. It was not regular 25-35 days but still had my period every month. I’ve been taking my inositol last 6 months and it regulated my period. I’ce started taking omega 3, coq10, vitamin d as well

Anyone had a similar background and have a success story

Hi , im 36 , never pregnant, and have had 2 failed transfer (1- didnt implant the 2- early miscarriage) . Ive had a couple of transfers cancelled due to fluid. Any recommendations from your experiences on fluid in lining? I have fluid sliver in lining (tiny bit) that bothered my doctor and he recommends canceling it.

I have the following on CD9 and doctor is leaving it up to me if i cancel or move forward with the hope that it will clear with PIO shots.

CD9:

• Estradiol 105

• Progesterone 0.75

• Lining 9.1 mm, trilaminar , very tiny bit of fluid

• Follicle 20.6 mm (biggest one)

Will need to trigger tonight but have to make a decision.

Embryo is 3AA, day 5.

Any recommendations is highly appreciated 🥹

Hey there 🤍 I’m currently going through fertility treatments and taking Letrozole with a trigger shot, and I’m just feeling a bit discouraged right now. I’m 9 DPO and got what I think is a negative test, which has been hard.

I wanted to ask—has anyone else gone through this kind of fertility treatment and had success? I would really love to hear your stories if you’re open to sharing.

Also, for those who did get a positive, what DPO did you test positive?

I think I’m just needing a little encouragement in this moment. Thank you so much 🤍