GLP-1s for Infertility/Before IUI or IVF
Has anyone used GLP-1 peptides for infertility and/or prior to pursuing IUI/IVF? I've seen many anecdotes of accidental pregnancies while on these medications. I know they're not recommended if you're actively TTC.
I'm 37, 2 years of TTC with no success. I've never had a positive pregnancy test. I have regular 27 day cycles, 11-12 day luteal phase. I do have insulin resistance and I've been working to improve it over the last year and a half. I've lost 15lbs, lost inches in my waist and gained muscle, and dropped my A1C from 5.7 to 5.3. But I am still overweight. I've been on a lower carb diet but the weight loss has slowed down.
Other stats: AMH dropped from 0.9 to 0.6 in the last 6 months. FSH: 9.22 LH: 4.69 AFC: 29 Prolactin: 23.4 (slightly high). Ovulation tracked and regularly confirmed with BBT. Thyroid normal. No endo symptoms.
I've seen two different REs who've suggested IUI and IVF but due to "unexplained" infertility and age, I want to give myself the best chance before pursuing these difficult and expensive options, or hopefully be able to conceive without them. I'm debating pursuing a couple months of GLP-1 treatment (Tirzepatide) to drop more weight quicker and improve my insulin resistance, and improve my chances. We won't be scheduled for IUI/IVF for at least a few months no matter what.
What I've tried:
- 2 hysteroscopies (no polyps or fibroids)
- an HSG and an SIS (tubes clear, no blockages).
- semen analysis was "very good, above average".
- exercise (weightlifting and cardio training minimum 2 days a week, usually 3)
- acupuncture and traditional Chinese medicine
- keto diet (difficult to sustain, didn't last long)
- lower carb, higher protein, higher fiber diet (currently)
- metformin (currently)
- supplements: Ubiquinol, Myo + D Chiro Inositol, Fish oil, NAC,
- going on vacation + "just relax"