u/helpless11

Hi, I know tianeptine has a pretty bad reputation because of abuse/misuse at high doses, but here in Europe it’s prescribed as an antidepressant at low doses (up to 37.5 mg/day)

My psychiatrist prescribed it to me about a month ago, and I’ve been taking 12.5mg 3x a day for generalized/social anxiety, depression, and rumination

So far the side effects have been mild (mostly some brain fog). I maybe notice a subtle improvement in anxiety/depression, but it’s hard to tell. Nothing major yet. My Dr said it can take longer and told me to give it another month before deciding if it’s working.

I was wondering if anyone here has experience with it at prescribed doses. Thanks

Hi, I know tianeptine has a pretty bad reputation because of abuse/misuse at high doses, but here in Europe it’s prescribed as an antidepressant at low doses (up to 37.5 mg/day)

My psychiatrist prescribed it to me about a month ago, and I’ve been taking 12.5mg 3x a day for generalized/social anxiety, depression, and rumination

So far the side effects have been mild (mostly some brain fog). I maybe notice a subtle improvement in anxiety/depression, but it’s hard to tell. Nothing major yet. My Dr said it can take longer and told me to give it another month before deciding if it’s working.

I was wondering if anyone here has experience with it at prescribed doses. Thanks

Hi, I am wondering if anyone has had the opposite of the usual calming/grounding effect from low-dose daily caapi/harmalas?

I started taking a B. caapi liquid extract daily (10 drops around noon), standardized to roughly:

• Harmine 5.6 mg, Harmaline 0.1 mg, THH 4.5 mg, Total beta-carbolines 10 mg

I started it hoping it might help with my chronic anxiety, constant negative rumination, and low mood, since I’ve read many reports of low-dose caapi being anti-anxiety

But after about 7-10 days I seem to be getting the opposite:

• noticeably stronger baseline anxiety/inner overstimulation
• unable to fall asleep until 4-5 AM... and then waking after a few hours with pounding heart/adrenaline + hot flushes
• needing more oxazepam than usual just to calm down

For context, I’m also on Tianeptine (Coaxil) 12.5 mg 3x/day (started around 3 weeks ago) and added saffron extract a few days ago, so I realize there are multiple variables, but the timing seems to line up most with introducing the caapi

I’m mainly wondering whether low daily harmala doses can paradoxically increase anxiety/insomnia in some sensitive people, and whether 10 mg total beta-carbolines is enough to noticeably overstimulate the CNS?

Would appreciate hearing from anyone who have experimented with regular low-dose caapi/harmala use

Thank you

Hi, I wanted to ask if anyone has tried a DIY version of Auvelity and actually had success with it?

I’m mainly dealing with generalized anxiety disorder and a constant negative rumination loop that’s been really hard to break out of.

I’m in the EU so I can’t get Auvelity, so DIY is kind of the only option for me right now. I also can’t access the IR version of bupropion, as it doesn’t seem to be available here (the only option would be splitting XR tablets, which I know isn’t ideal).

If you’ve tried something similar, would you mind sharing what your setup looks like (bupropion + DXM), including approximate dosing, frequency, and which form of bupropion you’re using?

I know everyone reacts differently, just trying to get a sense of what’s worked for others

Thanks!

Hi, I’m wondering if anyone has experience with higher-potency B. caapi liquid extracts (like 40:1 or 50:1), especially when taken daily in low or microdoses for mental health.

I’m mainly interested in effects on anxiety, rumination, depression, and overall mood. Did you notice any clear effects, or were they more subtle (possibly even placebo-level)?

Thank you

Hi, I’m wondering if anyone has had success using LSD or psilocybin microdosing specifically for severe anxiety, persistent rumination.

I recently came off vortioxetine 20mg because it made my anxiety a lot worse. At this point I’m not looking to try another antidepressant. Over the past 15 years I’ve been on pretty much everything (including MAOIs like Nardil, and more recently ketamine), but most either didn’t help my anxiety or came with side effects.

Because of GAD, I’ve been taking oxazepam daily for years, so I know I’m dependent at this point. I’m not planning to taper right now (just trying not to increase the dose), but I’m aware it’ll likely be a long process when I do. I’ve read about the Ashton Method and might consider it down the line.

I’m in therapy and do cardio daily. I’m also on a medical ketogenic diet, and I do notice some mental benefits when ketones are higher (around 3–4 mmol/L), but it’s very hard to maintain consistently, especially as a vegetarian.

Would appreciate hearing from anyone in a similar situation, especially how MD affected your anxiety and how it interacted with benzos

Thank you

Hi, I’m wondering if anyone has experience with higher-potency B. caapi liquid extracts (like 40:1 or 50:1), especially when taken daily in low or microdoses for mental health.

I’m mainly interested in effects on anxiety, rumination, depression, and overall mood. Did you notice any clear effects, or were they more subtle (possibly even placebo-level)?

Thank you

Hi, I’m wondering if anyone has experience with higher-potency B. caapi liquid extracts (like 40:1 or 50:1), especially when taken daily in low or microdoses for mental health.

I’m mainly interested in effects on anxiety, rumination, depression, and overall mood. Did you notice any clear effects, or were they more subtle (possibly even placebo-level)?

Thank you