Hello, I've shied away from this sub because I am less interested in purely resolving symptoms of hyperacusis and more interested in resolving the underlying inflammation causing it. Mine was triggered by an acute injury, and is clearly related to neuroinflammation.
I've tried many of the popular supplements, as well as benzos and gabepentin and corticosteroids, and other than corticosteroids, I have found that megadoses, like 2000+mg a day, of PEA, a supplement that stabilizes microglial inflammation and is often used for mast cell activation syndrome, has been the single most helpful intervention, second only to dexmethasone injections. I would put the PEA megadose at around 50% efficacy of a steroid shot. Oral prednisone I would put at 25%.
Thought I'd share in the hopes it helps others. Magnesium, NAC, etc. also helpful obv. All an order of magnitude less than PEA. I started megadosing after realizing that the normal dose improved my symptoms drastically but wore off within hours. It is expensive but a miracle drug for me. YMMV.
To my surprise, there is a clinical trial ongoing, as of Feb 2026! https://clinicaltrials.gov/study/NCT06718452
I'm also working on a blog post about all the medical interventions I've tried, which were effective, and which weren't - and the different possible pathways of inflammatory injury.
Edit: I’m a bit overwhelmed by all the responses. I can’t give anybody medical advice. I’m going to delete my comments, but leave the post up. I won’t be responding to any more questions.