What to do next?
Please some advice! ❤️I am 43 years old and trying for one more child. I previously had two spontaneous pregnancies that happened very quickly, both first och second month with my ex. Those pregnancies were at 36.5 and 38.5 years old (after I froze eggs). Never had a miscarriage. My first child has a de novo (spontaneous) chromosomal mutation (not age-related) and I want a “normal” sibling for my son, my second child. I have a normal karyotype. Using proven donorsperm.
At age 36, I froze eggs from 3 retrievals (17 eggs total). They were thawed in Oct 2025, and all degenerated, which was devastating.😭
After that, I started this awful ivf-ride with so much pain and struggle. You are all so very strong and reading your stories is very helpful.❤️
Cycle 1 februari 2026 (age 43): Antagonist protocol (short) Leading follicle and asynchronous… • 3 eggs retrieved • 2 mature • ICSI used • 1 abnormal fertilization • 1 degenerated after injection
Because of both this terrivble cycle and the thaw experience, there is now a hypothesis that my eggs may be sensitive to ICSI handling / cumulus cell removal… hence we let the support cells stay for the second try now i april.
Cycle 1,4 mars -suppose to be duostim/back to back. Cancelled. Super-asynchrony
Cycle 2 april 2026 (age 43):
Very synchronized cohort after 3 weeks of GnRH-downregulation, agonist protocol. 🙏😭🌟🌟🌟Big improvement: • 8 follicles • 7 eggs retrieved • 6 mature • Conventional IVF used (no ICSI) (this is it for me!! • 4 fertilized normally • 4 made it to day 3 • 3 reached blastocyst stage on day 6
Unfortunately, all 3 had to little cells for freezing/biopsy/transfer on day 6.😭what the F! The embryologt said they do not go to day 7 at their lab…almost no fragmentation.
I’m heartbroken because this felt so close. A marathon and I fell right in the end…
Please help!
Has anyone age 43 had almost-there embryos and then gone on to have success in a later cycle with their own eggs? Give me some hope.
Lots of luck for all of you! ✨✨✨✨
Ps, in Europe/Scandi so no addons possible going to a neighboring country for ERs where PGT is allowed