u/Sitij_thapa_123

This post contains content not supported on old Reddit. Click here to view the full post

Can anyone here tell me the level of question they might ask in MCB LMU exam. I have attached some example of questions so just tell me the questions are gonna be more hard or easier than these ones.

1. A secreted protein is found to accumulate in the cytosol when cells are treated with a drug that dissipates the proton gradient across the rough endoplasmic reticulum (ER) membrane but leaves the cytosolic ATP level unchanged. Which step in the protein’s trafficking is most directly impaired by this drug?

A Vesicular transport of the folded protein from the ER to the cis-Golgi

B Cleavage of the N-terminal signal peptide by signal peptidase

C Co-translational import of the polypeptide through the Sec61 channel into the ER lumen

D

2. Binding of the ribosome–nascent chain complex to the Sec61 transloconA mutation in a gene encoding a nuclear envelope protein leads to fragile nuclei that rupture under mild mechanical stress. Fibroblasts from an affected patient show misshapen nuclei and increased DNA damage. Which molecular defect best explains this phenotype?

A Loss of importin- α α function leading to reduced nuclear import of transcription factors

B Loss of nucleolus organizer regions (NORs) from acrocentric chromosomes

C Defective nuclear pore complex assembly causing global block of nucleocytoplasmic transport

D Mutation in lamin A/C disrupting the nuclear lamina meshwork

Hi, guys MCB exam is really near and I want to know if what type of questions they may ask I'll attach an example just tell me the level of questions, somewhat easy or more hard than these.

1. A secreted protein is found to accumulate in the cytosol when cells are treated with a drug that dissipates the proton gradient across the rough endoplasmic reticulum (ER) membrane but leaves the cytosolic ATP level unchanged. Which step in the protein’s trafficking is most directly impaired by this drug?

A Vesicular transport of the folded protein from the ER to the cis-Golgi

B Cleavage of the N-terminal signal peptide by signal peptidase

C Co-translational import of the polypeptide through the Sec61 channel into the ER lumen

D Binding of the ribosome–nascent chain complex to the Sec61 translocon

2. A mutation in a gene encoding a nuclear envelope protein leads to fragile nuclei that rupture under mild mechanical stress. Fibroblasts from an affected patient show misshapen nuclei and increased DNA damage. Which molecular defect best explains this phenotype?

A Loss of importin-α α function leading to reduced nuclear import of transcription factors

B Loss of nucleolus organizer regions (NORs) from acrocentric chromosomes

C Defective nuclear pore complex assembly causing global block of nucleocytoplasmic transport

D Mutation in lamin A/C disrupting the nuclear lamina meshwork

If anybody knows anything please just help me.