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A 2026 meta-analysis of 10 randomized controlled trials evaluated the effects of NMN (250–1500 mg/day) on blood pressure.

Key Points:

• Diastolic blood pressure decreased by about 2.15 mmHg
• Systolic blood pressure showed a downward trend
• Adults 60+ saw ~3.9 mmHg reduction in SBP
• NMN was well tolerated across trials

Details:

Even small reductions in blood pressure can have positive effects at the population level. A ~2 mmHg drop in DBP has been associated with reduced cardiovascular and stroke risk. The data suggests NMN may provide modest support for vascular health, particularly in older adults where NAD+ levels decline.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/nmn-supports-healthy-blood-pressure-in-adults-evidence-from-human-trials

A 2026 clinical study examined how NMN and NR (1,200 mg/day) affect NAD+ levels in both blood and brain.

Key Points:

• Blood NAD+ increased gradually and plateaued after ~2 weeks
• Brain NAD+ rose to about 40% above baseline after 4 weeks
• Effects were consistent in both healthy individuals and Parkinson’s patients
• NAD+ declined gradually over 2–3 weeks after stopping

This is one of the clearer human timelines for NAD+ kinetics. The data suggests NAD+ elevation is cumulative, not immediate, and requires consistent intake over weeks to fully manifest, especially in the brain.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/nmn-nr-increase-nad-in-blood-and-brain