u/PlyaVibes

59M here, very active (cycling 150–200 miles/week + strength training 1–2x/week). I’ve been diagnosed with a JAK2-related condition and my doctor plans to start me on hydroxyurea at age 60.

I’m trying to understand real world experiences from others on this medication.

For those taking hydroxyurea:

• How did it affect your energy and endurance (especially for endurance sports)?
• Did you notice any changes in recovery, strength, or ability to push hard efforts?
• Any day-to-day side effects that impacted your active lifestyle?

Also:

• Did it affect your sex life at all (libido, erections, overall function)?
• If yes, was it temporary, dose-related, or persistent?

Any insights, patterns, or things you wish you knew before starting would be really helpful.

Appreciate any firsthand experiences—thanks.