u/Medium_Leadership611

I’m looking for some advice on my current lab results and how to proceed.

My Genetics & Background:

• MTHFR: A1298C Heterozygous

• Gilbert’s Syndrome

• Update on COMT: I just submitted my DNA for an Ancestry test. I personally suspect I have a FAST COMT because I have mild ADHD-like symptoms (racing thoughts, talking fast, constantly dropping things). However, some people say reacting poorly to methyl-vitamins points to a SLOW COMT. I'm very confused by this paradox.

My Recent Lab Results (mid-April):

• Homocysteine: 21.0 µmol/l (Reference: <10)

• Active B12 (Holo-TC): 89.8 pmol/l (Reference: 37.5 - 188)

Supplements & Medications:

• I took a comprehensive Multivitamin complex (Eqology Nordic Energy Booster) throughout February and March. I stopped taking them exactly 1 week before my blood test. Daily doses: B12 (10 mcg), Folate (200 mcg as active Quatrefolic), B6 (2.8 mg).

• I take 5 mg Cialis (Tadalafil) daily.

My Lifestyle:

• I smoke about 4 cigarettes, 3 times a week.

• I drink about 2 liters of beer once a week (mostly on Fridays).

• High daily caffeine intake.

The Problem:

I don't get massive panic attacks from active methyl-B vitamins, but I definitely have the slight feeling that I feel better and more balanced without them. They just make me feel a bit restless or mildly jittery.

My Questions:

1. Could my Holo-TC (89.8) still be high from the supplements even after a 7-day break?

2. With only A1298C Hetero, is 21.0 Homocysteine likely driven more by my lifestyle (smoking/alcohol/caffeine) depleting my nutrients?

3. What is the gentlest way to lower homocysteine without methyl-donors? (Currently focusing on Choline/Eggs).

4. Does anyone else experience this mix of fast COMT (ADHD traits) but feeling slightly "off" on methyls?

5. Can I take Glutathione or NAC? I currently have the ones from KeKo Naturals. Would this help my liver (Gilbert's) and the oxidative stress from smoking without messing with my methyl-cycle?

Thanks for your help!

Hi everyone,

Are there people here who have lipomas and also know they have elevated homocysteine levels (e.g., due to MTHFR mutations)?

I came across a very interesting biochemical connection: High homocysteine has been shown to downregulate or inhibit the PTEN gene, which is a crucial tumor suppressor. PTEN normally acts as a brake on cell division and growth. If this brake is blocked by excess homocysteine, fat cells might grow unregulated, leading to the formation of lipomas.

Has anyone here looked into this specific pathway (Homocysteine -> PTEN inhibition -> Lipomas)? Even better, has anyone noticed their lipomas stopping to grow or shrinking after successfully lowering their homocysteine levels (via methylation support etc.)?

Would love to hear your experiences and thoughts on this!

Hi everyone,

I hope someone here can help me out.

I recently started taking a multivitamin supplement (Nordic Energy Booster), but I've noticed that I often feel quite restless, jittery, and just overall "bad" after taking it. It feels like some kind of overmethylation or like my nervous system is getting way too wired.

Briefly about my genetics: I am only heterozygous for MTHFR A1298C (C677T is normal). I actually thought I wouldn't have major issues with this mild mutation.

Could this be due to the specific forms of B vitamins in this supplement (Methylcobalamin, Quatrefolic, P5P)? Or do you see anything else in the ingredient list that could trigger this inner restlessness or discomfort?

Here are the ingredients and dosage (Recommended daily dose = 4 tablets, but I feel the side effects even at a lower dose):

Ingredients:

Natural magnesium hydroxide from seawater (Aquamin™), esterified vitamin C as calcium ascorbate (Ester-C®), magnesium bisglycinate chelate (Pharmagnesia®), magnesium malate, bulking agents (microcrystalline cellulose, croscarmellose sodium), blueberry extract (Vaccinium myrtillus), zinc bisglycinate chelate (Core Chelate®), anti-caking agents (vegetable magnesium stearate, silicon dioxide), selenomethionine (Lynside® Forte Se+). Organic Ascophyllum nodosum natural iodine (PureSea® Natural), niacinamide, calcium D-pantothenate, pyridoxal-5-phosphate (B6), riboflavin (B2), thiamin (B1), copper sulfate, chromium picolinate, (6S)-5-methyltetrahydrofolate glucosamine salt (Quatrefolic®), glazing agents (hypromellose, vegetable glycerin), color (blueberry), D-biotin, methylcobalamin (B12).

Nutritional values per daily dose:

• Vitamin C (esterified): 400 mg

• Magnesium: 230 mg

• Niacin (Vitamin B3): 16 mg

• Pantothenic acid (Vitamin B5): 6 mg

• Zinc: 5 mg

• Vitamin B6 (P5P): 2.8 mg

• Riboflavin (Vitamin B2): 2.8 mg

• Thiamin (Vitamin B1): 2.2 mg

• Copper: 392 mcg

• Folate (Vitamin B9 as Quatrefolic): 200 mcg

• Iodine: 132 mcg

• Selenium: 100 mcg

• Chromium: 60 mcg

• Biotin (Vitamin B7): 50 mcg

• Vitamin B12 (Methylcobalamin): 10 mcg

• Blueberry extract: 25 mg

Has anyone with heterozygous A1298C had similar experiences with these ingredients? Should I switch to unmethylated forms of folate and B12 instead?

Thanks for your input!