Been dealing with this for years and finally have enough data to share. Looking for anyone who’s been through something similar.
**Background**
*2001*: Appendectomy complicated by peritonitis
*2002*: Angioedema, chronic bloating, diarrhoea
*2005*: Asthma (resolved with acupuncture)
*2006*–*present*: Dermatographic urticaria
*2013*–*present*: Chronic rhinitis, urticaria, flushing, GI symptoms
*2015*: Myopericarditis from recurrent bacterial tonsillitis
**Current symptoms**
• Fatigue and brain fog
• Bloating — almost completely gone since 2nd round of antibiotics
• Chronic rhinitis — worse with alcohol and high histamine foods
• Urticaria and facial flushing
• Anal itching — disappears completely on low histamine diet
• GERD triggered by caffeine and chocolate
• Anxiety and poor sleep
• Immediate reaction to alcohol — fatigue and rhinitis within hours
• Dermatographic urticaria since age 13
**Confirmed**
• SIBO (hydrogen) + IMO (methane) on breath test — H2 63ppm, CH4 25ppm
• Histamine intolerance
• Low DAO (improved from 1.0 to 15.1 U/mL on low histamine diet)
**Currently on**
• 3rd round of SIBO antibiotics
• Low FODMAP + low histamine diet since October 2025
• Probiotics and mucosal repair between rounds
**Blood results**
• IgA: 614–673 mg/dL consistently over 4 years across multiple labs (ref 70–400)
• IgE: 220–317 IU/mL consistently (ref <100)
• Eosinophils & Basophils: 7–9% for years, finally normalised April 2026 after SIBO treatment
• ASO: 258 IU/mL (ref <200) — elevated, chronically enlarged tonsil, history of myopericarditis from tonsillitis
• hsCRP: <0.30 — no systemic inflammation
• DAO: 1.0 to 15.1 U/mL after low histamine diet
• Calprotectin: <5 — no gut inflammation
• H. pylori: negative x2
• Candida: negative
• Nutrients: normal range (Vitamins, minerals etc…)
• Amylase / Lypase occasionally elevated
• Secretory IgA Feces: normal
• Coeliac DNA test: all gene mutations negative
• Yeast and Milk intolerance: 100% positive
• ANA, RF, anti-CCP, coeliac serology and genetics: all negative
Hormones and thyroid: all optimal
*My working theory* — 3 concurrent drivers
1. SIBO/IMO — confirmed, being treated, clearly improving
2. Chronic streptococcal tonsil colonisation — elevated ASO + enlarged tonsil + myopericarditis history. Possibly driving IgA elevation and chronic rhinitis independently
3. MCAS — dermatographic urticaria since 13, angioedema since childhood, immediate alcohol reactions, elevated IgE.
**Currently investigating**
Serum tryptase this week
Throat swab for Group A Strep
Urine albumin:creatinine ratio — kidney monitoring given persistent IgA elevation
Nephrology referral for the IgA elevation
**Questions**
1. Anyone had SIBO + MCAS + elevated IgA together? Did treating SIBO improve MCAS symptoms?
2. Anyone had elevated ASO with chronic tonsil issues? Did tonsillectomy help?
3. Did your eosinophils stay normalised after finishing SIBO antibiotics?
4. MCAS people — did IgA come down once mast cell activation was controlled?
5. Any experience with elevated IgA and kidney monitoring in the context of gut dysbiosis?
Happy to share more. Finally connecting the dots after years — just want to know if others have been here.