Looking for hope after 2 losses (chronic endometritis + immune issues)
TW: LC, blood
Hi everyone. I’m 35F and have been silently reading this sub for a while, but finally decided to post because I feel like I’m reaching the point where I really need support and hope from people who have similar experiences and truly understand this.
Pregnancy #1 (2019):
Successful pregnancy resulting in my LC.
Pregnancy #2 (October 2024):
In January 2025, I miscarried at 13 weeks. The pregnancy was complicated almost from the start - SCH, spotting, and 2 major bleeding episodes - but every ultrasound showed a normally growing baby. NIPT came back low risk and the baby had a heartbeat the day the miscarriage started.
The miscarriage itself was extremely traumatic. I ended up needing an emergency D&C for retained placenta, had severe blood loss, 2 blood transfusions, and a very long physical and emotional recovery. Testing showed no issues with the baby or placenta. At the time I was told it was likely just a terrible fluke.
Pregnancy #3 (September 2025):
At the 10 week ultrasound there was no heartbeat. Growth had stopped only a few days earlier. I had another D&C. Physically it was much less traumatic than the first loss, but emotionally it completely broke me.
All 3 pregnancies happened naturally within 1–2 cycles.
After the second loss we did:
- full RPL testing
- cycle monitoring
- semen analysis
- hysteroscopy
- SIS
- genetic testing for both me and my husband
- AMH testing
Everything came back normal except:
- positive uterine biopsy for chronic endometritis
- elevated TH1/TH2 ratio
The conclusion as of today is that my immune system may have been attacking these pregnancies, with chronic endometritis likely being a contributing factor.
Treatment so far:
- 2 weeks doxycycline + metronidazole
- repeat biopsy still positive
- then 2 weeks ciprofloxacin + metronidazole
- repeated ALICE biopsy and currently waiting for results
The current plan for the next pregnancy (after CE is cleared) is:
- progesterone
- blood thinners
- immune suppressor (Prograf)
We decided that this will be our final attempt. If it fails, we will stop trying and won’t pursue IVF. That decision has been incredibly hard, but we need a limit emotionally, mentally, and physically.
I’m looking for anyone with similar experiences:
- chronic endometritis
- elevated TH1/TH2 / immune issues
- Prograf during pregnancy
- successful pregnancy after recurrent loss
Or honestly just some hope from people who’ve been in this dark place. I’m exhausted, emotionally drained, and honestly terrified to try again.