Any ureaplasma parvum success stories with 3-4 weeks of moxifloxacin?
Looking for advice from people who’ve dealt with persistent Ureaplasma Parvum infection. The first doctor I ever saw about this (in 2021) said that treatment is "optional" (i got tested >10.000) and he just brushed it off. I got doxy for 10 days and forgot about it for years. I now realize that this was negligent, and I should have been more concerned.
I’ve tested positive for Ureaplasma parvum (semen PCR) many times since then. My partner and I have both been treated at the same time in 2 separate cycles, but she consistently develops a UTI on day 2 or 3 after sex, when at least 4+ weeks have passed since any antibiotic course.
My antibiotic history so far:
\* doxycycline 14 days + 1g azithro (failed) -> retested positively (for reference, this was october 2024.
\* azithromycin one-time doses of up to 2g several times (failed) -> retested positive (november 2024)
\* ciprofloxacin 10 days + 1.5g azithro (jan 2025) - initially got me a negative PCR 21 days afterwards, but alas, she was not treated alongside me the first time. our first time having sex after the negative test (2-3 weeks after), she didnt develop any symptoms, but surely enough, another 3 weeks later the next time we had sex, she got the same burning UTI. I am waiving this off as a case of boomerang. At this stage I note that the burning UTI always occurs on day 3 for her, and I never have any issues.
\* levofloxacin 10 days + azithro 1.5g FAILED in june 2025 (only me)
\* ciprofloxacin for a 2nd time in September 2025, 10 days for her, 14 for me + 1/2g azithro each -> she inevitably developed the same burning 5 weeks after sex, and I retested positively afterward. we did have sex towards the ends of our treatments though, so that might've been unhelpful in retrospect
\*we're currently both on moxifloxacin (a week in). She is doing 10 days, I am doing 14 and am considering extending up to 28 since I am the source of the infection.
Globally, my symptoms (in total) are pretty much absent, apart from:
urinary urgency/frequency (¬13 times per day or so), very mild and inconsistent pelvic discomfort. When I'm in a state of fear, I find that the urge to pee is suppressed neurologically, so not even that is a reliable symptom. If there is any discomfort, it is barely noticeable, like low-grade burning, ever present.
I have never had any consistent severe pain - i did get an occasional prostate "stinging" pain, with 6/10 intensity ONCE per month on average. It's been a month since my last one. Sometimes they'd happen twice within a week, but no consistent pattern. It was sometimes on the right side, sometimes the left.
- Sometimes after ejaculation, peeing would be mildly burning. I began practicing semen retention so
My partner gets burning symptoms on day 3 after intercourse, which resolve after treatment but tend to return every time, after 5 weeks pass following any antibiotic course. Her tests ironically didnt come out positive for ureaplasma parvum, EVER, but they were just regular vaginal swabs, not PCR tests, and notably these results were within a week of taking TMP. She did get E-coli positive though, and TMP resolved her symptoms reliably every time. Note: IDK if she got pescribed TMP every time, but she always got something you take for a few days. It always worked in alleviating her UTI, with ureaplasma parvum remaining questionable every time.
I have tested NEGATIVE for E.coli, and every other yeast/bacteria so many times, and had my urinal flora come back normal more times than I can count. Never has it been anything else besides Urealpasma parvum that appeared positive. I did have a complete pannel of STDs, all negative every time.
We supplement D-mannose once per day, and Lactogyn (\*Lactobacillus rhamnosus\* (GR-1®) and \*Lactobacillus reuteri\* (RC-14®)
My questions:
Has anyone had confirmed moxifloxacin eradication after multiple antibiotic failures like this?
Did extending moxifloxacin beyond 14 days (e.g. 21–28 days) actually change the outcome in your case?
Anyone with a specific match the UTI's onset and symptoms 2-3 days after sex who can share their story.
I’m trying to understand realistic next steps, not just repeating antibiotic cycles without progress. After so much negligence and malpractice, I don't trust Swiss doctors anymore, so I'm completely self-treating. The urologist I saw in Switzerland (jan 2026) had the audacity to repeat the STD panel I brought him the results of, only adding HPV, and giving me a single dose of azithromycine!!! That cost me 1700 EUROS!!! That's with him knowing my complete history and all! Everything except Parvum came back negative, big shock there. What a legal thief and sad excuse for a man.
Symptom-wise, specifically on day 5 of the current moxi course :
\- I developed chills, throat pain (like the start of a cold) and a fever. I didn't measure it, but I can feel these things and I know it wasn't higher than 37.4 C. I just covered myself in my blanket, left my feet uncovered, sweat it out and slept it off. On day 7, the chills were much diminished. I did feel weak on day 7 and the day before, moving about more slowly, but after eating raw ginger, I felt much better. Thankfully, neither of us have any of the scary moxi side effects some reported. I still feel a little tired and the throat pain is still present on day 8 but no fever or chills. My sleep is much more easily disturbed and shallow. I feel fatigued at the beginning of the day.
Any experiences or guidance will be greatly appreciated.
Personal note:
I default to physical work since I migrated abroad to live with her, and have no other reliable choices for work as of yet. I am naturally very careful on moxi, and the prospect of potentially not succeeding with a 14-day course, and having her develop the same UTI again, only to need to take antibiotics again and risk physical injury or further emotional damage from this UTI, is crushing. It does come as ironic luck that I'm out of work for pretty much the full duration of me taking this course. We do 70-80% intensity workouts at the gym with all of the safety precautions due to tendon irritability, but that's on pause after the chills started and probably throughout the course.