u/D-N-1

Hey everyone,

I’m reaching out to see if anyone else has experienced localized skin sensitivity while on a similar research protocol.

I’m currently 3 weeks into this stack and have titrated up to the following:

Current Protocol:

• Retatrutide: 2mg once per week (pinned PM).
• Tesamorelin: 2mg (5 days on / 2 days off, pinned fasted AM).
• KLOW Blend (BPC-157, TB-500, KPV, GHK-Cu): 4mg (pinned fasted AM with Tesa).

The Issue:

Starting this week, I’ve developed significant skin sensitivity specifically on the upper legs and lower abdomen. It’s highly sensitive to touch, clothing friction, and temperature changes (hot/cold).

There is no visible rash or redness, just the sensation of "raw" or overstimulated nerves.

Questions for the group:

1. ⁠Could the GHK-Cu in the KLO blend be contributing? I know it's great for skin remodeling, but I’m wondering if the systemic dose is causing a weird nerve response.
2. ⁠For those who had this, did it resolve as your body adjusted, or did you have to drop the dose/frequency?

Looking for any insight or "lab results" from your own experiences. Thanks! 🙏🏻

Hey everyone,

I’m reaching out to see if anyone else has experienced localized skin sensitivity while on a similar research protocol.

I’m currently 3 weeks into this stack and have titrated up to the following:

Current Protocol:

• Retatrutide: 2mg once per week (pinned PM).
• Tesamorelin: 2mg (5 days on / 2 days off, pinned fasted AM).
• KLOW Blend (BPC-157, TB-500, KPV, GHK-Cu): 4mg (pinned fasted AM with Tesa).

The Issue:

Starting this week, I’ve developed significant skin sensitivity specifically on the upper legs and lower abdomen. It’s highly sensitive to touch, clothing friction, and temperature changes (hot/cold).

There is no visible rash or redness, just the sensation of "raw" or overstimulated nerves.

Questions for the group:

1. ⁠Could the GHK-Cu in the KLO blend be contributing? I know it's great for skin remodeling, but I’m wondering if the systemic dose is causing a weird nerve response.
2. ⁠For those who had this, did it resolve as your body adjusted, or did you have to drop the dose/frequency?

Looking for any insight or "lab results" from your own experiences. Thanks! 🙏🏻

Hey everyone,

I’m reaching out to see if anyone else has experienced localized skin sensitivity while on a similar research protocol.

I’m currently 3 weeks into this stack and have titrated up to the following:

Current Protocol:

• Retatrutide: 2mg once per week (pinned PM).
• Tesamorelin: 2mg (5 days on / 2 days off, pinned fasted AM).
• KLOW Blend (BPC-157, TB-500, KPV, GHK-Cu): 4mg (pinned fasted AM with Tesa).

The Issue:

Starting this week, I’ve developed significant skin sensitivity specifically on the upper legs and lower abdomen. It’s highly sensitive to touch, clothing friction, and temperature changes (hot/cold).

There is no visible rash or redness—just the sensation of "raw" or overstimulated nerves.

Questions for the group:

1. Has anyone experienced this specifically with Retatrutide? I’ve seen some anecdotal reports of GLP-1/GIP/GCG agonists causing "skin pain," but I'm curious if Reta is the likely culprit here.

2. Could the GHK-Cu in the KLO blend be contributing? I know it's great for skin remodeling, but I’m wondering if the systemic dose is causing a weird nerve response.

3. For those who had this, did it resolve as your body adjusted, or did you have to drop the dose/frequency?

Looking for any insight or "lab results" from your own experiences. Thanks! 🙏🏻

Hi All 👋🏼 you were all so helpful on my last post that I thought I’d ask another question on something that is bugging me.

I have just started Tesamorelin (alongside Reta and KLOW) and I have a couple of questions.

Firstly regarding reconstitution - recommendations online say to recon a 10mg vial, you add 3ml of BacWater. This means that a standard 2ml dose is 60 units! Which is a huge injection and causes me discomfort. Could I just add in 1ml or 2ml and lower the units? Or is there a reason for that high of an amount?

Also, curious if anyone has had any side effects such as Nausea? For reference I take it first thing in the morning fasted.

Thanks all

Hi All 👋🏼 you were all so helpful on my last post that I thought I’d ask another question on something that is bugging me.

I have just started Tesamorelin (alongside Reta and KLOW) and I have a couple of questions.

Firstly regarding reconstitution - recommendations online say to recon a 10mg vial, you add 3ml of BacWater. This means that a standard 2ml dose is 60 units! Which is a huge injection and causes me discomfort. Could I just add in 1ml or 2ml and lower the units? Or is there a reason for that high of an amount?

Also, curious if anyone has had any side effects such as Nausea? For reference I take it first thing in the morning fasted.

Thanks all