u/Carver-

Published Empirical Experiment - ''Toward an Experimental Device-Independent Verification of Indefinite Causal Order'' Richter et. al 2026

Abstract:

In classical physics, events follow a definite causal order: the past influences the future, but not the reverse. Quantum theory, however, permits superpositions of causal orders—the so-called indefinite causal orders (ICOs)—which can provide operational advantages over classical scenarios. Verifying such phenomena has sparked significant interest, much like earlier efforts devoted to refuting local realism and confirming quantum entanglement. To date, demonstrations of ICO have all been based a process called the quantum switch and have relied on device-dependent or semi-device-independent protocols. Achieving a device independent verification of ICO would imply that nature allows for correlations that do not respect causality, independent of any experimental assumptions or underlying theoretical description of the experiment. To this end, a recent theoretical development introduced a Bell-like inequality that allows for fully device-independent verification of ICO in a quantum switch. Here we implement this verification by experimentally violating this inequality. In particular, we measure a value of 1.8328 ± 0.0045, which is 18 standard deviations above the definite causal order bound of 1.75. Our work presents the first implementation of a device-independent protocol to verify ICO, albeit in the presence of experimental loopholes. This represents an important step toward the device-independent verification of an ICO and provides a context in which to identify loopholes specifically related to the verification of ICO.

Paper: https://journals.aps.org/prxquantum/pdf/10.1103/5t2y-ddmt

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u/Carver- — 3 hours ago

Published Paper - ''Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants''

We acknowledge the date of this paper might not land ideally to some of our colleagues, but it is just an unfortunate coincidence.

Authors, abstract and link to full paper below:

Paula Berman, Janka Höfer, Herschel Mehlman, Efrat Almekias-Siegl, Olga Khersonsky, Younghui Dong, Uwe Heinig, Liron Sulimani, Let Kho Hao, Shahar Cohen, Yoav Peleg, Sagit Meir, Ilana Rogachev, David Meiri, Sarel J. Fleishman, Asaph Aharoni

Abstract

Psychedelic indolethylamines with therapeutic potential are naturally produced in plants, fungi, and animals. Here, we elucidated the complete N,N-dimethyltryptamine (DMT) biosynthetic pathway in hallucinogenic plant species traditionally used in shamanic rituals for spiritual healing. Leveraging the similarities in their chemical structures, we reconstructed in one plant assay the full biosynthetic pathways of five renowned natural psychedelics; psilocin and psilocybin found in mushrooms, DMT from plants, and bufotenin and 5-methoxy-DMT secreted by the Sonoran Desert toad. We further engineered halogenated analogs of these molecules, which do not naturally occur in plants and exhibit prospective therapeutic potential for psychiatric conditions. Blending catalytic functions across the tree of life, coupled with metabolic engineering guided by rational protein design of mutant enzymes, enabled substantially more efficient in planta production of the indolethylamine components.

This work establishes a versatile platform for concurrent biosynthesis and diversification of psychoactive indolethylamines, paving the way for their production in plants.

https://www.science.org/doi/epdf/10.1126/sciadv.aeb3034

reddit.com
u/Carver- — 4 hours ago