u/Badmaash1981

Hello. 44, almost 45 F. My husband and I have been through TTC since 2023. We were easily pregnant in 2021 but due to some life circumstances, had to abort the pregnancy, which we now regret terribly, but was necessary.

Since 2023, I have not been naturally pregnant once. My AMH is great, no obvious issues with any bloodwork, or any uterine cavity imaging. I have done HSGs and Saline Sonograms, ALL NORMAL. My lining is always excellent, triliminar and healthy. I eat very well and generally manage my stress alright.

I had an own egg euploid fail implantation last year. The following transfer was an untested, and i had a chemical very early. Fast forward to 2026, I have two donor egg euploids.

BLC6 test came out to be 1.6 so we did a lupron suppression. Medicated FET. failed implantation again. I had lots of allergies to Estradiol (hives on my face). I had a migraine that lasted 4 days post FET. We also tested that CD138 number and it was all fine.

I have one more euploid. The doctor wants to do some RI testing JUST IN CASE, and it is the upwards of 10k. And treatments for those conditions are not cheap. and controversial.

She does want me to do EMMA ALICE, which i want to do, and those are very actionable steps to take.

I wonder if i'm just in a bad luck spiral. or if i don't tolerate medicated cycles well. Maybe its nothing and it will just work next time?

I really dont know what to do. If you have any ideas, please let me know.

I take prednisolone, antibiotics and estradiol progesterone during the transfer.

Hello. I’m 44 and have a long painful journey of 6 ER, 3 FET. No success.

My problem is I had one own egg euploid failed transfer (no implantation) followed by an untreated chemical that was super early loss.

This year I finally have two euploid with donor egg. And my first transfer just had an implantation failure.

I’m just terrified that my journey is over. I have one more euploid. No obvious problems, uterus looks very good.

Had a bcl6 test of 1.6 and did 2 months of lupron suppression followed by a fully medicated cycle. I was on a lot of hormones (or lack thereof) since December.

I had one cancelled FET prep as I had a full blown period two months after lupron in the middle of prep for medicated FET.

My doctor says it could have been a bad stroke of luck or maybe the medicated cycle. She said we can just try again as is or try a natural protocol but she doesn’t see any reasons for the failure.

They suggested RI just in case but it’s hella expensive, and if I do end up having any of the bad
Diagnoses I am unlikely to do ongoing treatments like ivig and daily blood draws.

I’ve been through a lot and I just don’t think that will be the route for me.

I’m thinking of asking just for some basic add ins to cover the basis
- lovenox?
- aspirin
- Benadryl
- Prednisolone and antibiotics (also took that during transfer)

I have add saline sonograms, HSGs. No issues whatsoever.

I was pregnant in 2021 and everything was easy and well. My partner struggled with alcoholism at the time and we had to abort the baby because of our life situation.

So implantation can happen and has happened before. But I couldn’t get pregnant at all trying naturally since 2023. All that could be egg quality but it does seem strange that not even a miscarriage till my IVF untested pregnancy that ended in a chemical very soon.

I’m Living in daily dread that this is it. This is my last
Embryo. Euploid and graded well but my body rejecting implantations.

Please give me advice. I am super healthy overall but have gained weight during my journey. I tend to react strongly to hormones and do get fairly uncomfortable with strongly medicated FETs and ERs.

Is the protocol my issue?