Propranolol -> Ivabradine
Hello everyone. I was recently switched from propranolol to ivabradine and I’m on the struggle bus. I’m wondering if anyone can share their experience with this switch and how long the adjustment period was.
I’ve had POTS since 2022 and started propranolol in 2023. I took 80mg ER for several years and it was a miracle drug for me (50% improvement) although I still struggled with debilitating symptoms. My HR was around 80-90bmp at rest and around 130bpm standing quietly which is way better than it was unmedicated.
Fast forward to September — I had stents placed in both internal jugular veins to treat another problem. Suddenly my average BP fell to around 90/60. Nights as low as 60s/40s which isn’t really safe. We reduced my propranolol dose to 60mg and it had little effect on BP but my HR went up again
I discussed this with my cardiologist (POTS-informed) about ten days ago and she decided to switch me from the propranolol to ivabradine. The idea was to get better HR control without depressing my BP as much. I’ve been on 5mg ivabradine 2x daily for about a week.
It’s been a bit of a nightmare…my BP is still low, my HR is still just as high (plus a spike in afternoon HR between ivabradine doses) and I feel AWFUL. My objective vitals are about the same but I feel a lot worse subjectively — my postural headaches and dizziness are totally disabling and I also feel shaky, anxious, wired, restless, etc. I literally feel like I drank 8 cups of coffee in one go.
Has anyone experienced this when switching between these drugs? How long should I give this before it’s clear that the ivabradine is a bad fit (and this isn’t just propranolol withdrawal)?
I’m miserable but I don’t want to throw in the towel too soon because it’s not an option to go up on the propranolol again due to BP and I’ve already tried and failed midodrine, pyridostigmine, fludricortisone, and droxidopa. I’m also on fluids and IVIG (mostly for other issues) already.
Thank you 🙏