u/AstronomerNo1872

endometriosis/fertility

I’ve already had an excision surgery with an excellent specialist. After trying for over two years with no positive tests, I started going to a fertility clinic. I’ve tried medicated cycles with Letrozole, and have recently added LDN — currently at 3mg.

Has anyone with endo had luck with LDN helping them to conceive?

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u/AstronomerNo1872 — 22 hours ago

feeling defeated.

After having excision surgery with an excellent specialist, I was naively hopeful. (I want to add - I don't regret surgery at all; it improved my quality of life immensely, and my primary goal was never fertility.)

I've had lab work, more ultrasounds than I can count, an HSG, and have had my partner tested (no issues). I've been taking a prenatal, CoQ10, Omega 3, NAC, and Vitamin D. I eat healthfully 95% of the time (I'm not perfect!), don't smoke, very rarely drink, and exercise 6x/week.

It's been over two years of trying in some way, including tracking using OPKs. I have regular cycles and have confirmed ovulation with lab work. I just finished my 5th cycle of medicated timed intercourse with Letrozole and Progesterone.

And I have yet to see a single positive test.

The icing on the cake was my OBGYN asking me if I "stopped trying" because I "should have been pregnant by now."

I am not in a financial place to consider IVF at the moment, and I honestly feel defeated. I just wanted to vent to others who will get it.

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u/AstronomerNo1872 — 2 days ago

morning dosing & levothyroxine

I posted recently about feeling more fatigued since starting LDN. A few folks suggested taking it in the morning, which I’d like to try. I always take Levothyroxine first thing on an empty stomach and wait at least an hour before eating or taking other meds. Could I take my LDN with food later on? I’m thinking I shouldn’t mix it with Levothyroxine. Thanks in advance for any insight!

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u/AstronomerNo1872 — 4 days ago

cycle changes?

I’m trying to conceive, and have been taking progesterone for a luteal phase defect. Without it, I get my period 9dpo. With it, I get my period 13dpo.

I also recently got up to 4.5mg of LDN.

Well, this month I started spotting at 8dpo. This happened without progesterone, but never with. I also ovulated late this cycle, so something just feels off.

Has anyone else experienced this? I’m worried my period is coming really early.

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u/AstronomerNo1872 — 6 days ago

I am so upset and just need support.

I did timed intercourse this cycle with Letrozole. I am also on progesterone suppositories for a luteal phase defect. Without progesterone, I get my period about 9dpo. With it, I get my period about 13dpo.

Well, today is 8dpo and my period is starting. I have never experienced this with progesterone and I don’t understand. Granted, I think I missed a dose, but I’ve done that in the past and have not gotten my period this early. This makes me afraid my endometriosis is worsening again. I know I’m all over the place right now; I’m just so upset and confused.

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u/AstronomerNo1872 — 7 days ago

I started LDN at 0.5mg a few months ago for Hashimoto’s, endometriosis, and fertility. I’m up to 3mg.

I’m so happy that my periods are less painful! Big win for me.

However, I feel like I’ve been more tired than I was before. Wondering if anyone else experienced this and if it may lessen in time. I also feel like I’m a bit more moody. I’m supposed to increase my dose again soon, and i’m wondering if I should hold off. It’s also weird being constipated for the first time in my life, but that’s been more manageable than the fatigue.

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u/AstronomerNo1872 — 14 days ago

The only time I have gotten a ratio of over one is either in the months following excision surgery or when taking Ovidrel (which I know artificially alters the test). Is this bad? I read that a ratio of over 1 is needed for ovulation to happen, but based on lab work, I do ovulate. Is there a way to increase LH/is it helpful to have higher levels?

u/AstronomerNo1872 — 16 days ago