B12 injections helped at first, now severe fatigue + electrolyte issues — could this be methylation related?
Hi everyone,
I’m dealing with something complicated and I’m hoping someone here might have insight.
About 6 months ago I started B12 injections because I had low folate levels and reacted badly to folic acid. The idea was to see how I would respond to folate after correcting B12 first.
At the beginning, I felt great. I had a daily energy boost and felt like I was improving. But after about 2 weeks, everything crashed. I became extremely fatigued again, felt terrible, and suddenly couldn’t tolerate magnesium anymore — I would get really bad reactions.
At that time I was taking:
• B12 injections every other day (1.5 mg)
• A B-complex (without B6)
• Magnesium (around 400 mg daily)
• 5 mg folinic acid
I then went to a B12-focused doctor. He told me the folinic acid dose was way too high and that I only needed a B-complex twice a week. I followed his advice on the folinic acid and reduced it to 400 mcg.
Later on, after doing more research and experimenting:
• I tried vitamin B1 → this gave me extreme depressive thoughts and fatigue
• I did an HTMA test → showed copper toxicity, which is often linked to low B6
• I added B6 → felt better quite quickly
• Then I tried B1 again → and it massively “activated” my system
But again, after about 2 weeks, I crashed.
Now I feel completely stuck. I’ve tried:
• more potassium
• more sodium
• calcium
• magnesium
Nothing really works. I react badly to magnesium and calcium, and I feel:
• extremely fatigued
• mentally empty / brain fog
• like my whole system is out of balance
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My question:
Is it possible that adding B1 and B6 has now “activated” my methylation so much that 400 mcg of 5-MTHF is no longer enough?
Or could something else be going on here?