Have people's lives ever been directly at stake because of software you work on?
I'm not sure what I was listening to that prompted this thought.
Most of what I've done has either been creative/developer tools or libraries (like Realm and my own OODBMS). It's possible someone's life might be threatened by one of my bugs, but only as a result of someone else's software that embedded it.
However, back in 2010, I got a job at a company that was the Microsoft of Mining Software, working on a specialist 3D CAD product.
Think open-cut mines, tunnels, pretty much any aspect of mineral mining.
Stuff I worked on included road design for 150T trucks, spiraling down the side of the mine, and blasting patterns for explosives. We had world-class QA (NASA class?) but I always felt more weight of responsibility than any other job.