u/Amk_311

I’ve been taking seroquel since July of 2025. I currently am taking seroquel at night, 300mgs. In many ways this medication has been a miracle for me. However, come this January when i was increased to 150-200mg i started getting what i think are side effects. Suddenly my body didn’t have the urge to poop anymore and it would be days in between bowel movements. My stools have also been extremely soft, I haven’t had a solid bowel movement in months. The stools are soft and difficult to get out when I actually do go to the bathroom. I went to my gastroenterologist. They have me on a motility medication called motegrity, another chronic constipation med called ibsrela and I’m also taking MiraLAX daily all because of the side effect of chronic constipation and slow transit constipation. I tried fiber supplements to bulk up my stool and it totally back fired on me and made the slow transit even worse. Long story short, the motegrity motility medication stopped working about ten days ago. I keep passing soft blobs of stool but again no urge to defecate just feels like something is stuck. Anyway, has anyone else had these problems on seroquel? It’s like my body decided we will never poop normally again. I was also evaluated by pelvic floor physical therapy multiple times, everything seemed normal to them. My psychiatrist is out of the country until June so I guess I’m stuck like this until he comes back to America.

I started taking motegrity for the second time about two months ago. I also want to be upfront and state that I take psychiatric medications olanzapine and seroquel. The seroquel has given me even more slow motility ( hence the reason I started motegrity ). For my slow transit constipation I take motegrity 1mg, Ibsrela 50mg twice a day , and a capful of MiraLAX daily. When the motegrity was working I would have very satisfying bowel movements like within an hour of taking it. Something has shifted though. I noticed about a week ago I wasn’t having regular bowel movements and when I did have bowel movements my urgency to poop was very faint. I would simply go to the toilet using my squatty potty and would prepare to go to the bathroom because “it kinda” felt like had to poop. When I do poop my stools are pencil thin. My stools are soft and I can never clean myself 100% which drives me insane. I eat very healthy, mainly vegetables and protein. I’ve done pelvic floor physical therapy multiple times. I’m taking so many meds. I am miserable with the bloating and unsatisfying bowel movements. Idk what i expect out of this post . I guess I’m just looking for advice. I just don’t know what to do anymore 😞