u/Adorable_Pen_6287

Hi everyone,

My mum 70F has been diagnosed with B cell type indolent LPL/marginal lymphoma because her MYD88 has come as negative.
They have said she has waldenstroms (WM).

We’ve seen two doctors both giving different treatment options.
One is saying to go for zanubrutinib as she’s on the older side and there will be side effects to chemo.
The other is saying to go for chemo and if she needs to take Zanubrutinib later if she relapses then she can take it then instead of wearing it off now.

We are extremely conflicted as all of this is like diving into the unknown for us and we have no insight into either of these treatments.

Can anyone advise based on what they know or have been through.

Hi everyone,
My mum is 70 and has been diagnosed with Waldenström macroglobulinemia
and Lymphoplasmacytic lymphoma

slow-growing (indolent) B-cell non-Hodgkin lymphoma.

.
They can’t seem to tell which one it is more of because she isn’t showing many symptoms and her MYD is negative but lymphoma cells are showing present in the bone marrow.

We have been suggested two different treatments by doctors.

1. Regular chemo Rituximab & Bendamustine
2. Or Dexamethasone, Rituximab, and Cyclophosphamide
3. Targeted therapy with zanubrutinib

We are stuck in the middle because we are getting recommendations from both.

Once doc is saying because MYD is negative to go with regular chemo because she can then take zanubrutinib or any other drug later in her life when she’s older and if she wont be able to handle chemo.

The other doctor says to go with Zanubrutinib as it seems to be a less invasive and lifelong option but the side effects will still be there and might affect her heart rate? (She had a hole in her heart so has a stunt in it that’s closed it)

Would really appreciate any advice from anyone who has gone through any of this or can give me advice based on experience!

Or even tell me anything about the the effects of these treatments

We all have been so confused and overwhelmed with the overload of information.

I’m looking for a hematologist / oncologist in Dubai and Abu Dhabi for a second opinion. The case is pretty serious is looking for recommendations of a doctor or hospital that will review the case and is experienced.