Switching from Toujeo (300u/ml) to Optisulin (100u/ml) due to supply uncertainty – Dosage advice?
Hi everyone! I’m 27 yrs old and in my first year living with Type 1 Diabetes. Yay!
For context I live in a country where accessing technology and basic resources is very expensive. I rely entirely on a government program (PRODIABA) for my insulin, needles, and test strips, as I cannot afford to buy them myself. Our government is making significant budget cuts to public health and education. I get my supplies from a small public hospital, and I can only see my endocrinologist every 6 months, a private consultation is financially out of reach for me.
Since my diagnosis, I have been using Toujeo (Insulin Glargine 300u/ml). Recently, a woman whose daughter passed away (RIP) donated 4 boxes of Optisulin (Insulin Glargine 100u/ml) to me. These expire in September, October, and November of this year. The Toujeo I get from the hospital expires in late 2027. Given the political and economic uncertainty, I want to use the donated Optisulin first so I can stockpile my newer Toujeo pens as a "safety net" in case the government program stops providing supplies.
Since I am moving from a high-concentration insulin (300u/ml) to a standard concentration (100u/ml), I know the absorption and potency can feel different.
By what percentage should I lower my dose to avoid hypoglycemia during the transition? Has anyone else made this specific switch (U300 to U100)?
I take 20 units in the morning and 10 units at night (Total Daily Dose: 30 units of Toujeo). My intuition tells me to drop to 15 units in the morning and 5 units at night on the Optisulin to be safe. Does this sound like a reasonable starting point?
Thank you so much for reading and for any insight you can provide💙