u/Acceptable_Buyer_350

Hi everyone,

I’m trying to understand my experience on dexmethylphenidate XR and would really appreciate hearing from others with similar setups.

I’m currently on:

• dexmethylphenidate (extended release)
• 5mg Trintellix (vortioxetine)

Since restarting the stimulant, I’ve noticed a few things:

• appetite is significantly reduced during the day
• I can go long gaps without eating without realizing it
• afternoon “brain heaviness” or mental fatigue
• focus improves at times, but I also feel oddly drained/flat
• mild stomach sensitivity on some days
• when I’m off it, I feel more tired and unfocused

I’m trying to figure out what’s typical vs what might mean I need an adjustment.

Questions:

• Is this a common XR experience for others?
• Did adjusting dose/timing or switching meds help?
• Any experiences combining dexmethylphenidate with Trintellix?
• What helped you with appetite + energy balance?

Not looking for medical advice—just real-world experiences so I can discuss things better with my psychiatrist.

Thanks!