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Why ergothioneine behaves differently from most antioxidants
▲ 6 r/NooTopics+1 crossposts

Why ergothioneine behaves differently from most antioxidants

A few interesting points on ergothioneine that don’t get discussed much:

Ergothioneine isn’t just a generic antioxidant. It has a specific transporter (SLC22A4 / OCTN1), which is relatively rare and usually signals biological importance.

Because of that transporter, certain cells actively accumulate and retain it, while others don’t take it up much at all.

It also tends to concentrate in tissues under oxidative stress and can persist there for extended periods, which is very different from short-lived circulating antioxidants.

In a recent podcast, our co-founder and CEO, Baran Dilaver, discussed this with Dave Asprey.

Asprey compared ergothioneine to a “sister molecule” of glutathione, and Baran shared how he first came across it through a case where high-ergothioneine mushrooms (like porcini) were recommended for someone with severe cognitive decline, with noticeable behavioral changes.

They also touched on a few key points:

  • It’s present in mother’s milk
  • The body has specific transporters for it
  • It can concentrate in damaged tissue for extended periods

On the clinical side, Professor Barry Halliwell of Oxford University is currently running a trial on ergothioneine with early results described as "really promising" for Alzheimer's. Notably, the trial was crowd-funded rather than pharma-backed, because ergo is not patentable, public funds are required to show the benefits of this great molecule. His work also helped establish the minimum effective dose needed for supplementation to be meaningful

Practically speaking, getting meaningful amounts from diet alone would require consistently eating large amounts of mushrooms.

Full conversation:
https://youtu.be/FNfXonKPwwM?si=cqDzdERrIMaOjhM3

Curious if anyone here has looked into ergothioneine beyond just “another antioxidant.”

u/Feel-Wonderful — 36 minutes ago
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High-dose Brahmi / Bacopa monnieri (≥600 mg/day) significantly improved working and short-term memory compared to Ginkgo and placebo according to new 2026 meta-analysis

A network meta-analysis just published in Phytomedicine compared Bacopa monnieri and Ginkgo biloba for cognitive performance in healthy adults.

Key findings:

  • High-dose Bacopa (≥600mg/day) significantly outperformed Ginkgo AND placebo for working memory and short-term memory.
  • Lower doses (300mg) still performed better than Ginkgo for delayed memory, but the real gains showed up at 600mg+
  • Brahmi and Ginkgo did not differ in their effects on attention or processing speed.
sciencedirect.com
u/kkgy00 — 7 hours ago
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Looking for a UK supplier for NA Semax and NA Selank

I was wondering if anybody had and reputable suppliers in the UK for NA Semax and NA Selank? I’m struggling to find any reputable sites or suppliers.

Also, if anybody has any first hand experience with NA Selank and or Semax as opposed to the standard non NA variants that would be great. I’m trying to see what the best route for me to take is.

Thanks

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u/Own_Donut5363 — 3 hours ago
▲ 3 r/NooTopics

tampered tropisetron?

Hi, i’ve recently ordered tropisetron HCL from aniracetam eu, and besides the bitter taste it also tastes paradoxically sweet. Is it possible the tropisetron was cut with sugar? Can anyone with tropisetron powder vouch for what it should taste like?

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u/Shroomaway457 — 5 hours ago
▲ 2 r/NooTopics

Semax question and general nasal spray guidance

Iv used bromantane and semax a few times now. And bromantane definitely works very well tho I don’t know if I’m even spraying correctly. I feel like I’m not because when I spray semax I can taste it very strong in my throat it’s a nice chemical flavour. However that makes my throat a little sore and also makes me feel really nauseous after a while. Is this nausea from Semax because I’m swallowing the nasal spray? Has anyone else experienced similar and if so is it just a bad reaction Semax or is it due to incorrect application. Iv seen a few of the tutorials on how to apply properly but everyone says different things and I still don’t have a good protocol down so would appreciate any advice or shared experiences. Thank you. Also for anyone looking to try them for the first time happy to answer questions about my experience.

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u/Emotional_Respect289 — 11 hours ago
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