r/GHB_info

Guys, I’m struggling a lot with my severe insomnia and fasciculation syndrome (which is linked to sleep deprivation and gets worse when I don’t sleep well).

Right now I’m relying on antipsychotics but they destroy me psychologically after a few days of usage and not to mention the long list of side effects they have, which include prolonged QT syndrome, which can cause deadly arrhythmias. And for a year now I started to have heart palpitations so I’m super cautious now with these drugs.

So because it’s impossible for me to get pharma GHB in Xywav, I’m thinking about trying BD again. I’m suffering with this syndrome for 8 years now and I know that to get better I need to sleep at an appropriate time and for enough hours, which unfortunately for me is 9 hours.

I used NaGHB but was only getting 2-3 hours max per 4.5g dose and was having to take 4 doses to get the 9 hours and feel better but it’s way too much sodium and I had high blood pressure, so I had to stop using it. But it was working tremendously for the insomnia and the sleep. It was something that I could rely on knowing that it would work.

Talked with nearly all the vendors on DW and no one has K-GHB nor were willing to try and make it. So what’s left is trying BD again, even if it’s just occasionally.

Does anyone here have experience with BD strictly for sleep or at very moderate doses? Cause I know some people claim no side effects with it and also say side effects might be from impurities and not from BD it self.

There’s also 1,3 BD which is now sold in beverages (Ketohol) and it’s literally the same as 1,4 but it gets converted into BHB in the liver instead of GHB. If you research you’ll see that 1,4 BD is not for human consumption because it turns into GHB. But we know GHB is non-toxic at therapeutic doses.

I’m not here promoting 1,4 BD, I’m just asking questions cause I’m really struggling to get my life back. Benign fasciculation syndrome is no joke, the neuropathic pain and twitching are horrible, not to mention I also developed weakness.

Thanks.

I was addicted to 1,4b from September 2024 until the week before Christmas and unfortunately ive ended back on it again. For the last half of last year I had excruciating back pain and what i described as 'the feeling of the worst sunburn you've ever had in your life' all over my forehead.

Once i stopped using that all went away. Now im back on it its all come back, along with shin splints so bad that i struggle to walk. Im seeing my doctor for baclofen and valium next week (I cant get in sooner) but the pain is excruciating.

Has anyone else experienced this?

Hello
Usually I take 1.5 ml each 1.5hour with GBL

What should I do with BDO ?

Thanks

If you’ve gained a tolerance to one, does the other still produce an effect? Right now I’ve gained an insane tolerance to both BDO and G, they do nothing for me. But I have never once even tried GBL and am interested to if it will have a fresh tolerance
Any experiences? How does GBL generally compare?

CURRENT USE:

• ~15ml BDO daily for 7 months
• Dosing every 1-3 hours during the day, every 2-5 hours overnight
• I tapered and went through WD without meds in January over a 2 week period, resumed use after 10 days sober

WHAT I HAVE:

• 25mg baclofen (60 tabs)
• 300mg gabapentin (60 caps)
• ~0.3mg Phenazolam (RC benzo, last resort only)

ACQUIRED INFO:

From what I've read here, a good detox plan using the helper meds looks like:

• Baclofen 25mg 3x/day, ~every 5 hours, take 30 mins after final BDO dose
• Gabapentin 600-900mg 2x/day, morning and night, take with final BDO dose
• Take helper meds for 1 week and taper aggressively afterwards

QUESTIONS:

• When's the best time of day to take my final BDO dose?
• Has anyone had success with a similar plan, and how did you taper off the helper meds afterwards?

Any other suggestions or information would be greatly appreciated <3

I take bdo night for sleep, but my last batch (during covid) didn’t have any side effects other than dizziness then g out if I took too much. Now it’s around an hour of nausea before I knock out. These days I’m figuring out a dose, but it’s always less than 5ml. I’m figuring out dosing cause jumping to 5ml made me puke.

Back then i was using 5ml to knock me out to get some rem sleep cause of the lack of rem sleep due to the alcohol and consuming much few food calories. Now I’m eating food normally and drinking a couple times a month. I wasn’t on any medication and am not currently.

Was it cause I was drinking heavily back then? I slept relatively quicker back then I didn’t notice the nausea. Now it’s like onset, takes 30 minutes, I’m slightly nauseous not another 30.

I’m 5’ 9” 160lbs

Alcohol (ethanol) is generally much worse for the liver than 1,4-butanediol (1,4-BD), especially with chronic or heavy use. pubmed.ncbi.nlm.nih.gov

Alcohol (Ethanol) and Liver Damage

Ethanol is a well-established hepatotoxin. Chronic heavy consumption leads to:

• Alcoholic fatty liver (steatosis), alcoholic hepatitis, fibrosis, and cirrhosis.
• It causes oxidative stress, inflammation, fat accumulation, and cell death in the liver via metabolism (primarily by alcohol dehydrogenase and aldehyde dehydrogenase, producing acetaldehyde and reactive oxygen species).
• Epidemiology: Alcohol-associated liver disease (ALD) affects millions globally (prevalence around 4-5% in general populations, much higher in heavy drinkers). It accounts for a large share of liver disease deaths, cirrhosis cases, and transplants. Mortality rates have risen significantly in recent years. pubmed.ncbi.nlm.nih.gov
This is dose- and duration-dependent, with risks escalating over years of regular heavy drinking. Many people develop irreversible damage.

1,4-Butanediol (1,4-BD) and Liver Effects

1,4-BD is an industrial solvent and GHB precursor. It is metabolized in the liver primarily by alcohol dehydrogenase (ADH) to gamma-hydroxybutyraldehyde, then to GHB (via aldehyde dehydrogenase). This shares metabolic pathways with ethanol, leading to competitive inhibition when both are present. pmc.ncbi.nlm.nih.gov

Evidence on hepatotoxicity:

• Animal studies (e.g., rats) show mild-to-moderate liver inflammation or minor changes at high doses (e.g., 500 mg/kg), but not severe or statistically strong organ-specific toxicity in subchronic studies. No strong carcinogenic signal. ntp.niehs.nih.gov
• In human recreational/chronic misuse (often high/frequent doses), reports mention toxic hepatitis as a complication, along with other organ effects (kidneys, heart, etc.). This occurs in the context of heavy polydrug or compulsive use. pmc.ncbi.nlm.nih.gov
• Acute overdoses can cause severe effects (respiratory depression, coma, death), sometimes mimicking toxic alcohol poisoning, but liver damage is not the primary acute feature. Co-ingestion with ethanol can worsen outcomes, including increased mortality and tissue damage in animal models (due to competition for ADH, leading to higher levels of the parent compound or altered kinetics). pubmed.ncbi.nlm.nih.gov

1,4-BD lacks the extensive long-term population data of alcohol; use is less common and often episodic or addictive in specific contexts rather than a daily societal norm.

Key Comparison and Caveats

• Chronic exposure: Ethanol has far stronger, dose-dependent evidence for progressive liver scarring and failure. 1,4-BD can contribute to toxic hepatitis in heavy users but appears less potent per se for long-term fibrotic/cirrhotic disease.
• Acute/high-dose: Both are risky; 1,4-BD has a narrower therapeutic window for CNS/respiratory depression (via GHB), and mixing with alcohol is particularly hazardous. nejm.org
• Individual factors: Genetics (e.g., ADH/ALDH variants), dose, frequency, nutrition, and co-exposures matter for both. Neither is “safe.”
• Neither is recommended: 1,4-BD is not for human consumption and carries risks of addiction, overdose, and multi-organ toxicity.

Bottom line: Alcohol poses a substantially greater overall risk to the liver due to its prevalence, well-documented chronic effects, and public health burden. 1,4-BD is toxic (especially acutely or in combination), but not a comparable driver of widespread liver disease.

Hey guys!

I’d like to ask for some advice about tapering off GBL.

I was taking about 30 ml per day for a few months.

How should I start? How should I dose it, for how long, and I’d appreciate any tips. I have baclofen, but as far as sedatives go, I only have alprazolam.

Also, what should I expect during this period? How unbearable are the anxiety and insomnia likely to be?

I also have GABA, ashwagandha, lavender extract, omega-3, magnesium, Milgamma and some weed prepared. Could these be useful?

Thanks a lot for every advice!