Login

r/7_HOPE_Alliance

▲ 177 r/7_HOPE_Alliance+1 crossposts

This didn’t happen by accident. It happened because people showed up. Calls were made. Emails were sent. Voices were heard.

When it mattered most, this community stepped up and made it clear that a ban was not acceptable. That pressure made a huge difference.

Seriously, thank you so much to everyone who took the time to reach out to legislators, spread information, and stay engaged through all this uncertainty. It truly paid off.

I'm sure they'll try again next year but we'll have time to fight it just like we did this year💪

reddit.com
u/Open-Bowl-9572 — 11 days ago
▲ 16 r/7_HOPE_Alliance

The “7oh Binds Stronger Than Morphine” Claim Is Based on a Misreading of the Data

There’s a lot of misinformation going around about 7oh because people are misreading receptor binding studies.

One of the biggest claims being repeated is that 7oh binds stronger to MOR than morphine. That is not what the data shows.

What the studies actually show is that 7oh binds much stronger than mitragynine, but much weaker than morphine.

From Obeng et al. 2021, which directly compared mitragynine, 7oh, and morphine side by side in human mu opioid receptors:

Mitragynine Ki = 709 nM

7oh Ki = 77.9 nM

Morphine Ki = 4.19 nM

Lower Ki = stronger binding affinity.

So yes, 7oh binds about 14 to 22 times stronger at MOR than mitragynine.

But 7oh also binds about 14 to 22 times WEAKER at MOR than morphine.

A lot of people are repeating the “14x stronger” claim without mentioning that the comparison was against mitragynine, not morphine.

This misunderstanding has been repeated so often that many people now believe 7oh has stronger MOR binding than morphine, when the actual receptor binding data shows the opposite.

Obeng 2021 is considered one of the strongest references on this topic because it tested all three compounds in the same study using human MORs instead of pulling numbers from unrelated studies.

EDIT: I added a link in the comments to the Obeng 2021 study that was referenced in this post.

u/Open-Bowl-9572 — 5 days ago
▲ 21 r/7_HOPE_Alliance

Everyone in the 7oh and Kratom Community Should Do This NOW!

One thing EVERYONE in the 7oh and kratom community should do right now is write down your personal story and save it in the Notes app on your phone.

Write about how 7oh and/or kratom has helped you, what your life was like before, what you use it for, how it improved your quality of life, and what would happen if it got banned. Explain why adults deserve legal access and why prohibition would hurt real people.

When talking to lawmakers, always push for common-sense regulations instead of outright bans. Support things like age limits, lab testing, accurate labeling, child-resistant packaging, and clear warnings. Those are reasonable protections. Total prohibition is not.

Also please stop relying on copy-and-paste templates when emailing legislators. Staffers can instantly tell when they’re reading the same message over and over, and a lot of those emails get ignored. Personal stories are what actually matter. A real message from a real person explaining how 7oh or kratom changed their life has far more impact than some generic form letter.

And everyone needs to help out when other states are facing bans, even if your own state is currently safe. It’s easy to ignore these fights when they aren’t happening where you live, but the reality is your state could be next at any time. We’ve already watched multiple states suddenly introduce bans with very little warning.

If your state was under attack, you’d want people from all over the country calling, emailing, spreading awareness, and supporting your community too. That’s why we all need to help each other now. The more united we are, the harder it becomes for lawmakers to ignore us.

That’s how we fight this stuff. Together.

When lawmakers receive hundreds of genuine personal stories from actual people, it forces them to stop and think about the real human impact these laws would have instead of just treating 7oh and kratom consumers like statistics.

reddit.com
u/Open-Bowl-9572 — 7 days ago