u/tom-sparrow

Has anyone else had serious QC issues with Biotage columns?

When loading a colored sample onto the column, you should normally see a nice, round band/ring forming at the top of the stationary phase. Instead, we’re seeing completely irregular filling patterns — the solvent/sample front spreads randomly through the bed, which indicates channeling and poor packing.

The separation quality is terrible and so is reproducibility. Some columns behave differently straight out of the box under identical conditions.

At this point these Biotage columns feel like complete garbage for the price. Has anyone else experienced this?

Would be useful to know whether this is an isolated issue or if their QC has gone downhill generally.

Should the loading look like that?

Another one.