Need hope. Endometriosis on Bio Identical Progesterone and Tirzepatide
F:37 SW:184 CW:176
Currently been on tirzepatide started titrated up and am at 4mg right now. I had to slowly titrate up because I barely had an appetite even on a low doze, it was a struggle to get myself at 1000+ calories a day. I’ve gotten better about finding foods I can eat and that have enough nutrients. I get 90-120 grams per day and shoot for 25-35 grams of fiber a day (this one is the hardest for me with the lower appetite) and drink enough water and throw some electrolytes in there when I need them. I climb/lift/hike/walk 3-5 days a week and I count my calories to just see what I eat each day. I’m sure I’m counting them accurately, I use a food scale and mostly eat at home. I know I’m not overestimating how much I’m eating. I also eat pretty well. Mostly Mediterranean diet with lots of veggies and fruits (am Sicilian)
I’ve been on tirzepatide since January 2026 and have only lost 5-8lbs (it goes up and back down but at my lowest right now it’s -8 lbs) and have just stalled there for 3 months, even after going up in a dose. If I go up anymore I doubt I’ll be able to eat enough, but I will as soon as I can handle it. Thing is, I also have endometriosis and have suspected I have some hormone imbalances for like 10 years now. (Took forever and an 8cm endometria to find out I had endo)
I JUST started bio identical progesterone. Birth Control (nuva ring worked best) kinda helped with endo pain cause I could skip periods, but made all my other hormonal symptoms a little worse.
I’ve done hormone testing at different phases of my cycle several times and the one common thread was that while my estrogen and progesterone (and other hormones) were in normal range, I had far more estrogen compared to progesterone.
Started cyclical bioidentical progesterone a few days ago. And have been taking a liver support supplement that has milk thistle and artichoke in it, NAC. And I just added in DIM yesterday as well as activated charcoal that I take spaced out from other vitamins/meds and meals.
The progesterone so far has no side effects and I’ve been getting the best sleep of my life. So I’ve had more energy and less brain fog. Also immediately lost the 3 lbs of bloating I’ve been carrying around since my last period.
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I know it’s early, but for anyone who needed both hrt and glp-1, when did you see results? Need some hope. Seems like I may be turning a corner, but it’s been a LONG road.
I’ve been carrying around this weight and these symptoms that make me not feel like me ever since I went on the mirena 10 years ago and gained 60 lbs in 3 months. (Side note thyroid has been fine every single time I’ve checked it and have no food allergies or sensitivities). TIA for comments, support, or even just making through this long rant. ❤️