[Article] Microneedle-mediated polydeoxyribonucleotide nanoliposomes for skin penetration performance and anti-aging efficacy.
DOI: 10.3969/j.issn.1006-7264.2023.09.005
DOI: 10.3969/j.issn.1006-7264.2023.09.005
I know this sub has a lot of people that are curious about getting microneedling done professionally. I thought this was a good share to highlight when choosing a provider to make sure you understand how they would be managing the complications and who would be the one doing it.
Obviously we'd hope there wouldn't be any problems, but it's good to be proactive just in case.
Note: This is not my video, it's from Dr. Naana Boakye and here's the post.
The sale ends April 27th Korean Time. Here is a quick way to check the time there.
The sub's code will provide you guys with the highest possible discount available as an fyi. Moving forward I will continue to pin the current sales so they are easy to find.
Link is here
Code is SCIENCEPLS
For those of you who are new here, welcome! This is a series called Worth Reading, where I share recent medical literature (typically from the last year or two) that stands out as especially interesting, clinically relevant, or worth discussing.
A 2025 randomized controlled study compared standard microneedling paired with 3% polydeoxyribonucleotide (PDRN) salmon versus microneedling paired with platelet rich plasma (PRP) for wrinkles and facial hyperpigmentation in women with moderate skin aging changes. Both groups improved, but the PDRN group showed significantly greater wrinkle reduction, while improvement in hyperpigmentation was similar between groups. It’s a small, short-term study, but it adds interesting early evidence to PDRN as an evidence-based regenerative pairing for regular microneedling, particularly in wrinkle-focused protocols.
Hi all! I wanted to share a sale with one of the vendors that is ongoing through April 30th (at midnight.) Although I suspect this might be ongoing as it was happening in March I believe.
This is actually not through me/the sub, but wanted to share for those that are not aware you can use this. It's a one-time use per customer as an fyi.
Video is from theinjectormimi on IG.
Mimi talks about how underrated microneedling is in aesthetic medicine and how she's never seen the consistency of results from any treatment, like she has from microneedling.
Figured I'd start a recurring introduction thread for those that are new here.
I know a lot of people on Reddit are more comfortable reading than posting, and I think that’s especially true in a sub like this. Especially when getting started. A lot of people are just here to learn, take their time, and see how they feel before joining in. That’s totally okay.
But I also wanted to make a space that feels easier to join in if you’ve been wanting to comment/post and haven’t known where to start.
If you’re new, feel free to introduce yourself and share where you’re at, what brought you here, or what you’re hoping to learn.
You don’t need to write a lot. You can just say you’re new. Share a gif. Or share how you found this sub, what you’re hoping to learn, or where you are in your microneedling journey.
If you’re more experienced, I’d love for you to introduce yourself too. Not just because newer people might feel more comfortable seeing people at different levels here, but also because it would be good to hear what more experienced users are interested in seeing more of too. That way the sub can grow in a way that feels useful and interesting for people across different experience levels.
And if you’d rather keep lurking for now, that’s okay too. You’re still welcome here.
Welcome to the second rendition of the monthly what's in your cart thread!
This monthly thread is for sharing what’s in your cart right now, whether you’re seriously planning to buy it or just curious about it. They can be products you’re eyeing, have been researching, or are planning to buy. They can be treatment related products, between-session skincare, or other beauty/skincare items that are still relevant to your routine, recovery, or treatment goals. They do not have to be products you already purchased.
If you can't make up your mind on an item, something new has launched, curious on other people's experiences with a product, you’ve had your eye on something, or you’ve been building out your routine, this is the place to share it.
This thread can include both.
Treatment related and sterile-relevant products
Products you’re considering for use during microneedling, for slip, for combo with other DIY treatments, or in the immediate post-treatment window where product choice matters more.
Cosmetic needling / nano needling products
Products you’re considering for cosmetic needling or nano needling, where intended use may differ from both deeper treatment products and general topical skincare.
General skincare / between-session products
We’re also trying out the broader general skincare / between-session category in this first thread. It could get boring if a bunch of people just comment Hyaron and Curenex or OwnDoc HA lol. That part is more of a test, and we’ll see whether it continues long-term or starts to feel too off-topic. This can include products you use outside of treatment sessions as part of your regular routine, including moisturizers, specific ingredients, barrier support, hydration, pigment support, hair/scalp products, and other beauty/skincare products relevant to your goals or routines.
If this monthly thread in general starts to feel too spammy or repetitive, we can also adjust or remove it.
Relevant topics can include things related, but are not limited to:
You’re welcome to share:
If you’re sharing what’s in your cart, please use the template below.
Suggested template:
Category: Treatment-related / Immediate post-treatment / General skincare or between-session skincare/beauty
Product(s) in cart: Product names or broken links
Concern/goal: What do you plan on using them for
Why I’m considering it: (Don't need this, but can include if wanting more feedback)
Used it before?: Can collapse this into another section if needed.
Looking for feedback or just sharing?:
Example:
Category: Treatment / Other DIY / General skincare/beauty
Product(s) in cart: Curenex, Hyaron, Youthfill PN, Timeless Vitamin C
Concern/goal: Simple glide for microneedling (HA + booster), polynucleotides for deeper remodeling, and a good topical vitamin C for in-between treatments
Planned use: Curenex and Hyaron for MN treatment, Youthfill PN for a different DIY use, and Timeless Vitamin C for general skincare
Used before?: Yes, have used all three
Feedback or just sharing?: Just sharing!
Link sharing note:
For now, I think it's safe to share links. I don't think this sub is big enough to actually disrupt any vendors or break any links. But I will monitor this as an fyi.
Thanks! Looking forward to seeing what everyone’s eyeing this month.
- Science Please
Here's a video by miaskinbar (on instagram) where she talks about sanitation. Also about technique direction, how to handle more mature skin, and atrophic scars.
I think it also brings to the conversation... about microneedling with minor breakouts or when the skin is mostly clear. I know this topic can be controversial, so I think it might be more beneficial for people for me to share resources that cover different angles.
She basically says if someone has an active breakout or two she still will needle, but just avoids needling it directly. But a few years ago she would've cancelled the appointment and sees it as beneficial to needle the skin around it.
The discussion of granulomas has been top of mind lately (and for good reason!) so I wanted to include more resources on them and how to avoid them.
This is a great video from skinbyhaidyn (on IG) where she breaks down why she instructs clients to do nothing post treatment. Now as others have pointed out, when we say "nothing" that can be taken as different interpretations. Nothing is important if you do not have sterile, intradermally designed products. If you are using products that are designed to be used intradermally then that is a different thing. The average person/ client is not buying medical grade products that are injectable grade. So videos like this are not targeted with that in mind :)
25% off site-wide
The sale ends April 19th Korean Time. Here is a quick way to check the time there.
The sub's code will provide you guys the highest possible discount available as an fyi. Moving forward I will pin the current sales so they are easy to find.
Link is here
Code is SCIENCEPLS
I'm going to be adding more resources that extend to longevity. I thought this was a good breakdown for methods on how to support the mitochondria.
This is from Dr. Kay Linker on instagram. I did not make this content as an fyi.
I've noticed lots of men joining the aesthetic space and think sharing some guy specific content/resources can be helpful.
Men’s aesthetics is growing fast and most guys still don’t know where to start. This mini guide is also from Dr. Ryan R. Riahi (IG handle is ryanriahimd) and this is a link to the post on instagram if you want to check it out and check his profile out.
Note: This is not my content.
We don't see people talk about doing their chest enough so wanted to share!
I also thought this was a good example when people ask about the different ways to apply glide when microneedling, you can see in the second slide they're using a syringe (sans needle) for applying it.
This is not my content (pictures or videos) and is from @ ryanriahimd and this is a link to the post if you want to look or look at more of his content.
Wanted to share this video breakdown of microneedling vs chemical peels.
Note: This is not my video. It is from @ westend.medspa on IG.
Found this video on instagram and thought it could be helpful for newbies that are trying to find more resources breaking down what to do and not to do around microneedling.
Copy Within the Video
Start prepping your skin 5-7 days before. Your skin should be calm, hydrated, and not irritated going into treatment.
Retinol for 5-7 Days. Retinol, Tretinoin, and Retin-A increase skin sensitivity and can lead to irritation.
Exfoliating Acids for 3-5 Days. Your skin barrier should be in tact before treatment.
Sun exposure for 7 days. Sunburned or inflamed skin cannot be safely microneedled. Wear spf daily.
Waxing or lasers for 7 days.
Blood-thinning supplements. 3-5 days before treatment avoid fish oil, vitamin E, and Aspirin (unless prescribed). These can increase bleeding during treatment.
Note: This is not my video. It is from @ vcglaserstudio on IG.
Meamo is having a 72-Hour spring sale for 25% off all products.
For first-time customers, they are offering a random Medicube gift as well.
The sub's code will provide you guys the highest possible discount available as an fyi. Moving forward I will pin the current sales so they are easy to find.
Please note: This is in Korean Time. Here is a quick way to check the time there if you don't feel like looking it up.
Hi hi, I wanted to share another educational video. This one is on elastin.
Note: thiis not my video and I am not taking credit as an fyi! I just think it's a great simplified breakdown.
I won't belabor it, so just sharing the post copy that was actually posted with the video:
>Elastin is a key protein of the extracellular matrix. It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. In humans, elastin is encoded by the ELN gene
Video Source: Animated Biology with Arpan
I wanted to share some more shipping updates with you guys.
Starting April 26, 2026, there will be a temporary 8% increase on USPS shipping prices. This will end January 27th, 2027. It is labeled as temporary and said to be driven by fuel and transportation costs spiking. This affects Priority Mail, Priority Mail Express, Ground Advantage, and Parcel Select. First Class stamps are not affected by this April surcharge. But, there is a separate stamp increase to 82¢ proposed for in July 2026.
This is stemming from a bigger picture situation for USPS and imo matters more than the surcharge right now. The agency is running out of cash by 2027. So they are taking emergency actions like suspending pension payments, considering fewer delivery days, and raising prices repeatedly. The agency has faced ongoing policy directions of pressure to be self-funded (privatized), restrictions compared to private carriers (pricing, services, etc), and political disputes over delivery frequency, rural service obligations, and pricing flexibility. So although this increase is temporary, the upward pricing pressure seems to not be temporary. This might not be relevant for some vendors, but think it's worth sharing.
At this moment, private carriers (UPS, FedEx, etc) do not have a temporary surcharge. But UPS has explicitly said competitors already have much higher fuel surcharges (around 25–28%). Which means private carriers already priced in fuel volatility and USPS is basically catching up.
There is still a partial government shutdown as of today. This hits travel, logistics, and imports. It's normal to expect custom delays and slower regulatory processing.
Sources
USPS Announcement
Axios - Stamp proposal increase
Reuters - USPS price increase
AP News - USPS emergency actions