negative ANA but high centromere B antibody???
I (23f) was screened for ANA’s due to suspecting possible autoimmune disease. I’ve been having excessive fatigue, joint pain, major brain fog and back to back cold-like respiratory illnesses. I’ve also began having tachycardia, shortness of breath, dizziness, blood rushing to my head and mottling in my hands typically accompanied by tingling sensations, that I suspected was blood pooling in my hands however the ER doctor did say it could potentially be Raynauds. They have attributed these symptoms to POTS as of right now. My ANA titer was in the negative range at 1:320, however my Centromere B was >8. From my research it seems this result is rare. My question is, is it more likely ANA is a false negative or centromere B is a false positive? And are there circumstances in which high levels of centromere B are normal and not indicative of an autoimmune condition? Additionally, do my symptoms seem as if they could be the beginning symptoms of systemic sclerosis?