Friendship with non-human intelligence
I have noticed that Sam has said quite a few times that friendship/companionship with AI is meaningless (unless you are in hospice or have Alzheimers). While I agree with that claim for today's AI, I am surprised that he doesn't think that it is equally inevitable that as machines get more intelligent they will become more worthy companions.
Stating that it is not possible to have meaningful companionship with super intelligent AI would be the same as saying it is impossible with aliens in my opinion.
All of this is to say that I think that as much as Sam Harris is very on point in the AI field I do think he has a blind spot when it comes to this part as if it is truly substrate independent then I don't think there is anything that a human can do that something else cannot.