Surmount-Maintain results and thoughts
441 people studied over 112 weeks…
0-60 weeks at max tolerated dose (10 or 15mg)
60-112 weeks, either stayed on max dose, went down to 5mg, or stopped zepbound
84 weeks - individuals who regained 50%+ of weight was allowed to increase dose
“Among participants who regained at least 50% of lost bodyweight, observed means were 11 (8%) of 138, 35 (25%) of 142, and 60 (67%) of 90 participants received rescue therapy in the tirzepatide MTD, 5 mg tirzepatide, and placebo, respectively”
So…
-if you stayed on your highest tolerated dose after week 60… 8% regained 50%+ of body weight and had to increase dose
-If you stopped to 5mg, 25% regained 50%+ of body weight and increased dose
-If you stopped zepbound, 67% gained 50+% of body weight and had to increase dose
overall… over 112 weeks (bit over 2yrs)
-Those on max tolerated dose lost 21.9% body weight over the 112 total weeks
-Those who reduced to 5mg after 60 weeks lost 16.6% body weight over 112 total weeks
-Those who stopped zep lost a total of 9.9% body weight over 112 total weeks
Important note I see is that this shows that even staying on max dose… it generally seems that everyone does eventually hit a barrier in terms of being able to continue weight loss
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00656-2/abstract