u/mieziem

Titration - inconsistent response

Hi,

I’m (f,36) currently in the titration phase with lisdexamfetamine and I’m trying to understand what’s going on, because my response feels really inconsistent.

Here’s my situation:

I started at 10 mg and am now taking 20 mg.

On 20 mg I’ve had some really good days:

I felt calm, clear, and structured, household tasks didn’t bother me, I just did them.

I had less overthinking, was more social, and more confident. Even my usual anxiety was basically gone, things felt “easy” and natural.

BUT:

Now I’m having days where it feels completely different, even though I’m taking the same dose (20 mg).

On those days:

I feel unstructured again, like without meds.

I get overwhelmed by small things (mess, tasks, decisions). It’s hard to start or finish tasks (like laundry or replying to messages)

I get irritated and impatient quickly and I feel more sensitive to noise (even small sounds feel too loud)

I also feel more anxious again, similar to how I felt before medication.

At the same time:

I feel tired, like I could fall asleep, almost like I didn’t take anything, just had a bit of coffee. Motivation drops quickly after a short “okay-ish” phase.

So it’s not a clear “too much” or “too little” feeling.

I started titration before my period and I felt like it worked best while I was on my period.

Does this sound more like underdosing or overdosing?

I have an appointment coming up on Monday, I just kind of want to try to figure out myself what's going on beforehand.

Any input would be so appreciated :)

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u/mieziem — 16 hours ago